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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL3898
Target Type SINGLE PROTEIN
Preferred Name Bone morphogenetic protein 1
Synonyms BMP-1 | BMP1 | Bone morphogenetic protein 1 | Mammalian tolloid protein | PCOLC | PCP | Procollagen C-proteinase | mTld
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > protease > metallo protease > metallo protease mam clan > metallo protease m12a subfamily

Target Components

Component Description Relationship Accession
Bone morphogenetic protein 1 SINGLE PROTEIN P13497

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000168487
Ensembl ENSG00000168487
GO Cellular Component GO:0005576 (extracellular region)
GO:0005578 (proteinaceous extracellular matrix)
GO:0005615 (extracellular space)
GO:0005794 (Golgi apparatus)
GO:0031988 (membrane-bounded vesicle)
GO Molecular Function GO:0004222 (metalloendopeptidase activity)
GO:0004252 (serine-type endopeptidase activity)
GO:0005125 (cytokine activity)
GO:0005160 (transforming growth factor beta receptor binding)
GO:0005509 (calcium ion binding)
GO:0005515 (protein binding)
GO:0008083 (growth factor activity)
GO:0008233 (peptidase activity)
GO:0008237 (metallopeptidase activity)
GO:0008270 (zinc ion binding)
GO:0016787 (hydrolase activity)
GO:0046872 (metal ion binding)
GO Biological Process GO:0001501 (skeletal system development)
GO:0001502 (cartilage condensation)
GO:0001503 (ossification)
GO:0006508 (proteolysis)
GO:0007275 (multicellular organism development)
GO:0010862 (positive regulation of pathway-restricted SMAD protein phosphorylation)
GO:0022617 (extracellular matrix disassembly)
GO:0030154 (cell differentiation)
GO:0030509 (BMP signaling pathway)
GO:0042157 (lipoprotein metabolic process)
GO:0042981 (regulation of apoptotic process)
GO:0043408 (regulation of MAPK cascade)
GO:0048468 (cell development)
GO:0051216 (cartilage development)
GO:0060395 (SMAD protein signal transduction)
GO:0061036 (positive regulation of cartilage development)
Wikipedia Bone_morphogenetic_protein_1

Target Cross References - Protein

canSAR P13497
CGD Osteogenesis imperfecta, type XIII
Human Protein Atlas ENSG00000168487
IntAct P13497
Guide to Pharmacology 2333
Open Targets ENSG00000168487
PharmGKB PA25377
Reactome R-HSA-1474228 (Degradation of the extracellular matrix.)
R-HSA-1650814 (Collagen biosynthesis and modifying enzymes.)
R-HSA-194223 (HDL-mediated lipid transport.)
R-HSA-2214320 (Anchoring fibril formation.)
R-HSA-2243919 (Crosslinking of collagen fibrils.)
UniProt A8K6F5 B2RN46 D3DSR0 P13497 Q13292 Q13872 Q14874 Q99421 Q99422 Q99423 Q9UL38

Target Cross References - Domain

InterPro IPR000152 (EGF-type_Asp/Asn_hydroxyl_site.)
IPR000742 (EGF-like_dom.)
IPR000859 (CUB_dom.)
IPR001506 (Peptidase_M12A.)
IPR001881 (EGF-like_Ca-bd_dom.)
IPR006026 (Peptidase_Metallo.)
IPR009030 (Growth_fac_rcpt_.)
IPR013032 (EGF-like_CS.)
IPR015446 (BMP_1/tolloid-like.)
IPR018097 (EGF_Ca-bd_CS.)
IPR024079 (MetalloPept_cat_dom.)
IPR034036 (ZnMP_TLD/BMP1.)
Pfam PF00431 (CUB)
PF01400 (Astacin)
PF07645 (EGF_CA)

Target Cross References - Structure

PDBe 3EDG 3EDH
CREDO 3EDG 3EDH
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