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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL3893
Target Type SINGLE PROTEIN
Preferred Name Pyruvate dehydrogenase kinase isoform 3
Synonyms PDHK3 | PDK3 | Pyruvate dehydrogenase kinase isoform 3 | [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 3, mitochondrial
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > atypical protein kinase group > atypical protein kinase pdhk subfamily

Target Components

Component Description Relationship Accession
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 3, mitochondrial SINGLE PROTEIN Q15120

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2096665 Pyruvate dehydrogenase kinase PROTEIN FAMILY

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000067992
Ensembl ENSG00000067992
GO Cellular Component GO:0005739 (mitochondrion)
GO:0005759 (mitochondrial matrix)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0004672 (protein kinase activity)
GO:0004674 (protein serine/threonine kinase activity)
GO:0004740 (pyruvate dehydrogenase (acetyl-transferring) kinase activity)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0016301 (kinase activity)
GO:0016740 (transferase activity)
GO Biological Process GO:0005975 (carbohydrate metabolic process)
GO:0006006 (glucose metabolic process)
GO:0010510 (regulation of acetyl-CoA biosynthetic process from pyruvate)
GO:0010906 (regulation of glucose metabolic process)
GO:0016310 (phosphorylation)
GO:0018105 (peptidyl-serine phosphorylation)
GO:0035357 (peroxisome proliferator activated receptor signaling pathway)
GO:0071333 (cellular response to glucose stimulus)
GO:0071398 (cellular response to fatty acid)
GO:0097411 (hypoxia-inducible factor-1alpha signaling pathway)
GO:2000377 (regulation of reactive oxygen species metabolic process)
Wikipedia PDK3

Target Cross References - Protein

canSAR Q15120
CGD Charcot-Marie-Tooth disease, X-linked
Human Protein Atlas ENSG00000067992
IntAct Q15120
Open Targets ENSG00000067992
PharmGKB PA33156
Pharos Q15120 (Tbio)
Reactome R-HSA-204174 (Regulation of pyruvate dehydrogenase (PDH) complex.)
R-HSA-5362517 (Signaling by Retinoic Acid.)
UniProt B4DXG6 Q15120

Target Cross References - Domain

InterPro IPR003594 (HATPase_C.)
IPR005467 (His_kinase_dom.)
IPR018955 (BCDHK/PDK_N.)
Pfam PF02518 (HATPase_c)
PF10436 (BCDHK_Adom3)

Target Cross References - Structure

PDBe 1Y8N 1Y8O 1Y8P 2PNR 2Q8I
CREDO 1Y8N 1Y8O 1Y8P 2PNR 2Q8I
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