ChEMBL logo

ChEMBL

spacer
ChEMBL Statistics
  Loading Statistics...
spacer

Target Report Card

Target Name and Classification

Target ID CHEMBL3890
Target Type SINGLE PROTEIN
Preferred Name Selectin E
Synonyms CD62 antigen-like family member E | CD_antigen=CD62E | E-selectin | ELAM-1 | ELAM1 | Endothelial leukocyte adhesion molecule 1 | LECAM2 | Leukocyte-endothelial cell adhesion molecule 2 | SELE
Organism Homo sapiens
Species Group No
Protein Target Classification
  • adhesion

Target Components

Component Description Relationship Accession
E-selectin SINGLE PROTEIN P16581

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL3831288 Selectin PROTEIN FAMILY

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL3707446 RIVIPANSEL Selectin E antagonist 3 PubMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000007908
Ensembl ENSG00000007908
GO Cellular Component GO:0005615 (extracellular space)
GO:0005886 (plasma membrane)
GO:0005901 (caveola)
GO:0005905 (clathrin-coated pit)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0030863 (cortical cytoskeleton)
GO:0045121 (membrane raft)
GO:0048471 (perinuclear region of cytoplasm)
GO Molecular Function GO:0004888 (transmembrane signaling receptor activity)
GO:0005515 (protein binding)
GO:0030246 (carbohydrate binding)
GO:0033691 (sialic acid binding)
GO:0043274 (phospholipase binding)
GO:0070492 (oligosaccharide binding)
GO Biological Process GO:0002092 (positive regulation of receptor internalization)
GO:0002523 (leukocyte migration involved in inflammatory response)
GO:0006954 (inflammatory response)
GO:0007155 (cell adhesion)
GO:0007157 (heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)
GO:0007159 (leukocyte cell-cell adhesion)
GO:0007202 (activation of phospholipase C activity)
GO:0019722 (calcium-mediated signaling)
GO:0030029 (actin filament-based process)
GO:0032496 (response to lipopolysaccharide)
GO:0034612 (response to tumor necrosis factor)
GO:0050727 (regulation of inflammatory response)
GO:0050900 (leukocyte migration)
GO:0050901 (leukocyte tethering or rolling)
GO:0070555 (response to interleukin-1)
Wikipedia E-selectin

Target Cross References - Protein

canSAR P16581
Human Protein Atlas ENSG00000007908
IntAct P16581
Open Targets ENSG00000007908
PharmGKB PA35640
Reactome R-HSA-202733 (Cell surface interactions at the vascular wall.)
UniProt A2RRD6 P16111 P16581

Target Cross References - Domain

InterPro IPR000436 (Sushi_SCR_CCP_dom.)
IPR000742 (EGF-like_dom.)
IPR001304 (C-type_lectin-like.)
IPR002396 (Selectin_superfamily.)
IPR013032 (EGF-like_CS.)
IPR016186 (C-type_lectin-like/link.)
IPR016187 (CTDL_fold.)
IPR018378 (C-type_lectin_CS.)
IPR033991 (Selectin_CTLD.)
Pfam PF00008 (EGF)
PF00059 (Lectin_C)
PF00084 (Sushi)

Target Cross References - Structure

PDBe 1ESL 1G1T 4C16 4CSY
CREDO 1ESL 1G1T 4C16 4CSY
spacer
spacer