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Target Report Card

Target Name and Classification

Target ID CHEMBL3886
Preferred Name Mixed lineage kinase 7
Synonyms HCCS-4 | Human cervical cancer suppressor gene 4 protein | Leucine zipper- and sterile alpha motif-containing kinase | MLK-like mitogen-activated protein triple kinase | MLK-related kinase | MLTK | MRK | Mitogen-activated protein kinase kinase kinase MLT | Mixed lineage kinase-related kinase | Sterile alpha motif- and leucine zipper-containing kinase AZK | ZAK
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > tkl protein kinase group > tkl protein kinase mlk family > tkl protein kinase mlk subfamily

Target Components

Component Description Relationship Accession
Mitogen-activated protein kinase kinase kinase MLT SINGLE PROTEIN Q9NYL2

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000091436
Ensembl ENSG00000091436
GO Cellular Component GO:0005634 (nucleus)
GO:0005737 (cytoplasm)
GO Molecular Function GO:0000287 (magnesium ion binding)
GO:0004709 (MAP kinase kinase kinase activity)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0042802 (identical protein binding)
GO Biological Process GO:0000077 (DNA damage checkpoint)
GO:0000186 (activation of MAPKK activity)
GO:0007050 (cell cycle arrest)
GO:0007257 (activation of JUN kinase activity)
GO:0008219 (cell death)
GO:0008283 (cell proliferation)
GO:0009314 (response to radiation)
GO:0030154 (cell differentiation)
GO:0043065 (positive regulation of apoptosis)
Wikipedia ZAK

Target Cross References - Protein

Human Protein Atlas ENSG00000091436
IntAct Q9NYL2
Guide to Pharmacology 2289 (ZAK sterile alpha motif and leucine zipper containing kinase AZK)
UniProt B3KPG2 Q53SX1 Q580W8 Q59GY5 Q86YW8 Q9HCC4 Q9HCC5 Q9HDD2 Q9NYE9 Q9NYL2

Target Cross References - Domain

InterPro IPR000719 (Prot_kinase_cat_dom.)
IPR001245 (Ser-Thr/Tyr-Pkinase.)
IPR001660 (SAM.)
IPR008271 (Ser/Thr_prot_kinase_AS.)
IPR010993 (Sterile_alpha_motif_homology.)
IPR011009 (Kinase-like_dom.)
IPR013761 (SAM_type.)
IPR021129 (SAM_type1.)
Pfam PF00536 (SAM_1)
PF07714 (Pkinase_Tyr)