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Target Report Card

Target Name and Classification

Target ID CHEMBL3886
Preferred Name Mixed lineage kinase 7
Synonyms HCCS-4 | Human cervical cancer suppressor gene 4 protein | Leucine zipper- and sterile alpha motif-containing kinase | MLK-like mitogen-activated protein triple kinase | MLK-related kinase | MLTK | MRK | Mitogen-activated protein kinase kinase kinase MLT | Mixed lineage kinase-related kinase | Sterile alpha motif- and leucine zipper-containing kinase AZK | ZAK
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > tkl protein kinase group > tkl protein kinase mlk family > tkl protein kinase mlk subfamily

Target Components

Component Description Relationship Accession
Mitogen-activated protein kinase kinase kinase MLT SINGLE PROTEIN Q9NYL2

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

GO Cellular Component GO:0005634 (nucleus)
GO:0005737 (cytoplasm)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0000287 (magnesium ion binding)
GO:0004672 (protein kinase activity)
GO:0004674 (protein serine/threonine kinase activity)
GO:0004709 (MAP kinase kinase kinase activity)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0016301 (kinase activity)
GO:0016740 (transferase activity)
GO:0044822 (poly(A) RNA binding)
GO:0046872 (metal ion binding)
GO Biological Process GO:0000075 (cell cycle checkpoint)
GO:0000077 (DNA damage checkpoint)
GO:0000186 (activation of MAPKK activity)
GO:0006468 (protein phosphorylation)
GO:0006950 (response to stress)
GO:0007010 (cytoskeleton organization)
GO:0007049 (cell cycle)
GO:0007050 (cell cycle arrest)
GO:0007257 (activation of JUN kinase activity)
GO:0008219 (cell death)
GO:0008283 (cell proliferation)
GO:0009314 (response to radiation)
GO:0016310 (phosphorylation)
GO:0030154 (cell differentiation)
GO:0035556 (intracellular signal transduction)
GO:0043065 (positive regulation of apoptotic process)
Wikipedia ZAK

Target Cross References - Protein

IntAct Q9NYL2
Guide to Pharmacology 2289
Open Targets
Pharos Q9NYL2 (Tchem)
UniProt B3KPG2 Q53SX1 Q580W8 Q59GY5 Q86YW8 Q9HCC4 Q9HCC5 Q9HDD2 Q9NYE9 Q9NYL2

Target Cross References - Domain

InterPro IPR000719 (Prot_kinase_dom.)
IPR001245 (Ser-Thr/Tyr_kinase_cat_dom.)
IPR001660 (SAM.)
IPR008271 (Ser/Thr_kinase_AS.)
IPR011009 (Kinase-like_dom.)
IPR013761 (SAM/pointed.)
IPR032938 (MLTK.)
Pfam PF00536 (SAM_1)
PF07714 (Pkinase_Tyr)

Target Cross References - Structure