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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL3884
Target Type SINGLE PROTEIN
Preferred Name Sodium/glucose cotransporter 2
Synonyms Low affinity sodium-glucose cotransporter | Na(+)/glucose cotransporter 2 | SGLT2 | SLC5A2 | Sodium/glucose cotransporter 2 | Solute carrier family 5 member 2
Organism Homo sapiens
Species Group No
Protein Target Classification
  • transporter > electrochemical transporter > slc superfamily of solute carriers > slc05 family of sodium-dependent glucose transporters

Target Components

Component Description Relationship Accession
Sodium/glucose cotransporter 2 SINGLE PROTEIN P31639

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL2103802 DAPAGLIFLOZIN PROPANEDIOL Sodium/glucose cotransporter 2 inhibitor 4 DailyMed
CHEMBL2103841 CANAGLIFLOZIN HYDRATE Sodium/glucose cotransporter 2 inhibitor 4 DailyMed
CHEMBL2107830 EMPAGLIFLOZIN Sodium/glucose cotransporter 2 inhibitor 4 FDA
CHEMBL1770248 ERTUGLIFLOZIN Sodium/glucose cotransporter 2 inhibitor 3 PubMed
CHEMBL1808388 BEXAGLIFLOZIN Sodium/glucose cotransporter 2 inhibitor 3 Other Other Other Other
CHEMBL2105711 TOFOGLIFLOZIN HYDRATE Sodium/glucose cotransporter 2 inhibitor 3 PubMed
CHEMBL3039507 SOTAGLIFLOZIN Sodium/glucose cotransporter 2 inhibitor 3 PubMed
CHEMBL2028665 REMOGLIFLOZIN ETABONATE Sodium/glucose cotransporter 2 inhibitor 2 PubMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000140675
Ensembl ENSG00000140675
GO Cellular Component GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0031526 (brush border membrane)
GO:0070062 (extracellular exosome)
GO Molecular Function GO:0005215 (transporter activity)
GO:0005362 (low-affinity glucose:sodium symporter activity)
GO:0005412 (glucose:sodium symporter activity)
GO:0015293 (symporter activity)
GO Biological Process GO:0005975 (carbohydrate metabolic process)
GO:0006810 (transport)
GO:0006811 (ion transport)
GO:0006814 (sodium ion transport)
GO:0008643 (carbohydrate transport)
GO:0015758 (glucose transport)
GO:0055085 (transmembrane transport)
GO:1904659 (glucose transmembrane transport)
Wikipedia SLC5A2

Target Cross References - Protein

canSAR P31639
CGD Renal glucosuria
Human Protein Atlas ENSG00000140675
Guide to Pharmacology 916
Open Targets ENSG00000140675
PharmGKB PA35902
Reactome R-HSA-189200 (Hexose transport.)
R-HSA-428808 (Na+-dependent glucose transporters.)
R-HSA-429593 (Inositol transporters.)
UniProt A2RRD2 P31639

Target Cross References - Domain

InterPro IPR001734 (Na/solute_symporter.)
IPR018212 (Na/solute_symporter_CS.)
Pfam PF00474 (SSF)
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