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Target Report Card

Target Name and Classification

Target ID CHEMBL3880
Target Type SINGLE PROTEIN
Preferred Name Heat shock protein HSP 90-alpha
Synonyms HSP 86 | HSP86 | HSP90A | HSP90AA1 | HSPC1 | HSPCA | Heat shock 86 kDa | Heat shock protein HSP 90-alpha | LAP-2 | LPS-associated protein 2 | Lipopolysaccharide-associated protein 2 | Renal carcinoma antigen NY-REN-38
Organism Homo sapiens
Species Group No
Protein Target Classification
  • other cytosolic protein

Target Components

Component Description Relationship Accession
Heat shock protein HSP 90-alpha SINGLE PROTEIN P07900

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2095165 Heat shock protein HSP90 PROTEIN FAMILY

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000080824
Ensembl ENSG00000080824
GO Cellular Component GO:0005576 (extracellular region)
GO:0005622 (intracellular)
GO:0005634 (nucleus)
GO:0005654 (nucleoplasm)
GO:0005737 (cytoplasm)
GO:0005829 (cytosol)
GO:0005886 (plasma membrane)
GO:0009986 (cell surface)
GO:0016020 (membrane)
GO:0016323 (basolateral plasma membrane)
GO:0016324 (apical plasma membrane)
GO:0031012 (extracellular matrix)
GO:0031526 (brush border membrane)
GO:0032587 (ruffle membrane)
GO:0042470 (melanosome)
GO:0043005 (neuron projection)
GO:0043025 (neuronal cell body)
GO:0043202 (lysosomal lumen)
GO:0043209 (myelin sheath)
GO:0043234 (protein complex)
GO:0048471 (perinuclear region of cytoplasm)
GO:0070062 (extracellular exosome)
GO:0071682 (endocytic vesicle lumen)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0002134 (UTP binding)
GO:0002135 (CTP binding)
GO:0003729 (mRNA binding)
GO:0004713 (protein tyrosine kinase activity)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0005525 (GTP binding)
GO:0016887 (ATPase activity)
GO:0017098 (sulfonylurea receptor binding)
GO:0019901 (protein kinase binding)
GO:0019903 (protein phosphatase binding)
GO:0023026 (MHC class II protein complex binding)
GO:0030235 (nitric-oxide synthase regulator activity)
GO:0030911 (TPR domain binding)
GO:0032564 (dATP binding)
GO:0042802 (identical protein binding)
GO:0042803 (protein homodimerization activity)
GO:0042826 (histone deacetylase binding)
GO:0044325 (ion channel binding)
GO:0044822 (poly(A) RNA binding)
GO:0051020 (GTPase binding)
GO:0051022 (Rho GDP-dissociation inhibitor binding)
GO:0051082 (unfolded protein binding)
GO Biological Process GO:0000086 (G2/M transition of mitotic cell cycle)
GO:0001764 (neuron migration)
GO:0003009 (skeletal muscle contraction)
GO:0006457 (protein folding)
GO:0006839 (mitochondrial transport)
GO:0006898 (receptor-mediated endocytosis)
GO:0006950 (response to stress)
GO:0006986 (response to unfolded protein)
GO:0007165 (signal transduction)
GO:0009408 (response to heat)
GO:0009409 (response to cold)
GO:0009651 (response to salt stress)
GO:0010592 (positive regulation of lamellipodium assembly)
GO:0010659 (cardiac muscle cell apoptotic process)
GO:0018108 (peptidyl-tyrosine phosphorylation)
GO:0031396 (regulation of protein ubiquitination)
GO:0033160 (positive regulation of protein import into nucleus, translocation)
GO:0038096 (Fc-gamma receptor signaling pathway involved in phagocytosis)
GO:0038128 (ERBB2 signaling pathway)
GO:0042026 (protein refolding)
GO:0043254 (regulation of protein complex assembly)
GO:0043335 (protein unfolding)
GO:0043627 (response to estrogen)
GO:0045040 (protein import into mitochondrial outer membrane)
GO:0045429 (positive regulation of nitric oxide biosynthetic process)
GO:0045793 (positive regulation of cell size)
GO:0046677 (response to antibiotic)
GO:0048010 (vascular endothelial growth factor receptor signaling pathway)
GO:0050790 (regulation of catalytic activity)
GO:0050821 (protein stabilization)
GO:0050999 (regulation of nitric-oxide synthase activity)
GO:0051131 (chaperone-mediated protein complex assembly)
GO:0060452 (positive regulation of cardiac muscle contraction)
GO:0061684 (chaperone-mediated autophagy)
GO:1900034 (regulation of cellular response to heat)
Wikipedia Heat_shock_protein_90kDa_alpha_(cytosolic),_member_A1

Target Cross References - Protein

canSAR P07900
Human Protein Atlas ENSG00000080824
IntAct P07900
Guide to Pharmacology 2905
Open Targets ENSG00000080824
PharmGKB PA29519
Reactome R-HSA-1227986 (Signaling by ERBB2.)
R-HSA-1236382 (Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants.)
R-HSA-1474151 (Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation.)
R-HSA-192905 (vRNP Assembly.)
R-HSA-2029482 (Regulation of actin dynamics for phagocytic cup formation.)
R-HSA-203615 (eNOS activation.)
R-HSA-2565942 (Regulation of PLK1 Activity at G2/M Transition.)
R-HSA-3000484 (Scavenging by Class F Receptors.)
R-HSA-3371511 (HSF1 activation.)
R-HSA-3371568 (Attenuation phase.)
R-HSA-3371571 (HSF1-dependent transactivation.)
R-HSA-380259 (Loss of Nlp from mitotic centrosomes.)
R-HSA-380270 (Recruitment of mitotic centrosome proteins and complexes.)
R-HSA-380284 (Loss of proteins required for interphase microtubule organization from the centrosome.)
R-HSA-3928663 (EPHA-mediated growth cone collapse.)
R-HSA-399954 (Sema3A PAK dependent Axon repulsion.)
R-HSA-4420097 (VEGFA-VEGFR2 Pathway.)
R-HSA-5218920 (VEGFR2 mediated vascular permeability.)
R-HSA-5336415 (Uptake and function of diphtheria toxin.)
R-HSA-5601884 (PIWI-interacting RNA (piRNA) biogenesis.)
R-HSA-5620912 (Anchoring of the basal body to the plasma membrane.)
R-HSA-5637810 (Constitutive Signaling by EGFRvIII.)
R-HSA-6785807 (Interleukin-4 and 13 signaling.)
R-HSA-6798695 (Neutrophil degranulation.)
R-HSA-8852276 (The role of GTSE1 in G2/M progression after G2 checkpoint.)
R-HSA-8854518 (AURKA Activation by TPX2.)
R-HSA-8863795 (Downregulation of ERBB2 signaling.)
UniProt A8K500 B3KPJ9 P07900 Q2PP14 Q5CAQ6 Q5CAQ7 Q9BVQ5

Target Cross References - Domain

InterPro IPR001404 (Hsp90_fam.)
IPR003594 (HATPase_C.)
IPR019805 (Heat_shock_protein_90_CS.)
IPR020568 (Ribosomal_S5_D2-typ_fold.)
IPR020575 (Hsp90_N.)
Pfam PF00183 (HSP90)
PF02518 (HATPase_c)

Target Cross References - Structure

PDBe 1BYQ 1OSF 1UY6 1UY7 1UY8 1UY9 1UYC 1UYD 1UYE 1UYF 1UYG 1UYH 1UYI 1UYK 1UYL 1YC1 1YC3 1YC4 1YER 1YES 1YET 2BSM 2BT0 2BYH More...
CREDO 1BYQ 1OSF 1UY6 1UY7 1UY8 1UY9 1UYC 1UYD 1UYE 1UYF 1UYG 1UYH 1UYI 1UYK 1UYL 1YC1 1YC3 1YC4 1YER 1YES 1YET 2BSM 2BT0 2BYH More...
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