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Target Report Card

Target Name and Classification

Target ID CHEMBL3876
Preferred Name Nuclear factor of activated T-cells cytoplasmic 1
Synonyms NF-ATc | NF-ATc1 | NFAT transcription complex cytosolic component | NFAT2 | NFATC | NFATC1 | NFATc | NFATc1 | Nuclear factor of activated T-cells, cytoplasmic 1
Organism Homo sapiens
Species Group No
Protein Target Classification
  • other cytosolic protein
  • transcription factor

Target Components

Component Description Relationship Accession
Nuclear factor of activated T-cells, cytoplasmic 1 SINGLE PROTEIN O95644

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000131196
Ensembl ENSG00000131196
GO Cellular Component GO:0000790 (nuclear chromatin)
GO:0005634 (nucleus)
GO:0005654 (nucleoplasm)
GO:0005737 (cytoplasm)
GO:0005829 (cytosol)
GO Molecular Function GO:0000977 (RNA polymerase II regulatory region sequence-specific DNA binding)
GO:0000980 (RNA polymerase II distal enhancer sequence-specific DNA binding)
GO:0001085 (RNA polymerase II transcription factor binding)
GO:0001205 (transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding)
GO:0003677 (DNA binding)
GO:0003700 (transcription factor activity, sequence-specific DNA binding)
GO:0003705 (transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding)
GO:0005515 (protein binding)
GO:0005528 (FK506 binding)
GO:0048273 (mitogen-activated protein kinase p38 binding)
GO Biological Process GO:0006351 (transcription, DNA-templated)
GO:0006355 (regulation of transcription, DNA-templated)
GO:0006366 (transcription from RNA polymerase II promoter)
GO:0007223 (Wnt signaling pathway, calcium modulating pathway)
GO:0030178 (negative regulation of Wnt signaling pathway)
GO:0033173 (calcineurin-NFAT signaling cascade)
GO:0035556 (intracellular signal transduction)
GO:0038095 (Fc-epsilon receptor signaling pathway)
GO:0045893 (positive regulation of transcription, DNA-templated)
GO:0045944 (positive regulation of transcription from RNA polymerase II promoter)
Wikipedia NFATC1

Target Cross References - Protein

canSAR O95644
Human Protein Atlas ENSG00000131196
IntAct O95644
Open Targets ENSG00000131196
PharmGKB PA31582
Reactome R-HSA-2871809 (FCERI mediated Ca+2 mobilization.)
R-HSA-4086398 (Ca2+ pathway.)
R-HSA-5607763 (CLEC7A (Dectin-1) induces NFAT activation.)
UniProt B5B2M4 B5B2M5 B5B2M6 B5B2M7 B5B2M8 B5B2M9 B5B2N1 O95644 Q12865 Q15793 Q2M1S3

Target Cross References - Domain

InterPro IPR002909 (IPT.)
IPR008366 (NFAT.)
IPR008967 (p53-like_TF_DNA-bd.)
IPR011539 (RHD_DNA_bind_dom.)
IPR013783 (Ig-like_fold.)
IPR014756 (Ig_E-set.)
IPR015647 (NFAT1.)
IPR032397 (RHD_dimer.)
Pfam PF00554 (RHD_DNA_bind)
PF16179 (RHD_dimer)