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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL3876
Target Type SINGLE PROTEIN
Preferred Name Nuclear factor of activated T-cells cytoplasmic 1
Synonyms NF-ATc | NF-ATc1 | NFAT transcription complex cytosolic component | NFAT2 | NFATC | NFATC1 | NFATc | NFATc1 | Nuclear factor of activated T-cells, cytoplasmic 1
Organism Homo sapiens
Species Group No
Protein Target Classification
  • other cytosolic protein
  • transcription factor

Target Components

Component Description Relationship Accession
Nuclear factor of activated T-cells, cytoplasmic 1 SINGLE PROTEIN O95644

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000131196
Ensembl ENSG00000131196
GO Cellular Component GO:0005634 (nucleus)
GO:0005737 (cytoplasm)
GO Molecular Function GO:0003677 (DNA binding)
GO:0003700 (sequence-specific DNA binding transcription factor activity)
GO:0005515 (protein binding)
GO:0005528 (FK506 binding)
GO:0010843 (promoter binding)
GO:0016563 (transcription activator activity)
GO Biological Process GO:0006355 (regulation of transcription, DNA-dependent)
GO:0006366 (transcription from RNA polymerase II promoter)
GO:0035556 (intracellular signal transduction)
Wikipedia NFATC1

Target Cross References - Protein

canSAR O95644
Human Protein Atlas ENSG00000131196
PharmGKB PA31582
UniProt O95644 Q12865 Q15793

Target Cross References - Domain

InterPro IPR002909 (IPT_TIG_rcpt.)
IPR008366 (NFAT.)
IPR008967 (p53-like_TF_DNA-bd.)
IPR011539 (RHD.)
IPR013783 (Ig-like_fold.)
IPR014756 (Ig_E-set.)
IPR015647 (NFAT1.)
Pfam PF00554 (RHD)
PF01833 (TIG)
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