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Target Report Card

Target Name and Classification

Target ID CHEMBL3873
Preferred Name Aminoacyl-tRNA synthetase
Synonyms Bifunctional aminoacyl-tRNA synthetase | Bifunctional glutamate/proline--tRNA ligase | Cell proliferation-inducing gene 32 protein | EPRS | GLNS | GluRS | Glutamate--tRNA ligase | Glutamatyl-prolyl-tRNA synthetase | Glutamyl-tRNA synthetase | PARS | Proline--tRNA ligase | Prolyl-tRNA synthetase | QARS | QPRS
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
Bifunctional glutamate/proline--tRNA ligase SINGLE PROTEIN P07814

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000136628
Ensembl ENSG00000136628
GO Cellular Component GO:0005737 (cytoplasm)
GO:0005829 (cytosol)
GO:0016020 (membrane)
GO:0017101 (aminoacyl-tRNA synthetase multienzyme complex)
GO:0030529 (intracellular ribonucleoprotein complex)
GO:0097452 (GAIT complex)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0003723 (RNA binding)
GO:0003824 (catalytic activity)
GO:0004812 (aminoacyl-tRNA ligase activity)
GO:0004818 (glutamate-tRNA ligase activity)
GO:0004827 (proline-tRNA ligase activity)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0016874 (ligase activity)
GO:0016876 (ligase activity, forming aminoacyl-tRNA and related compounds)
GO:0035613 (RNA stem-loop binding)
GO:0051020 (GTPase binding)
GO Biological Process GO:0006412 (translation)
GO:0006417 (regulation of translation)
GO:0006418 (tRNA aminoacylation for protein translation)
GO:0006424 (glutamyl-tRNA aminoacylation)
GO:0006433 (prolyl-tRNA aminoacylation)
GO:0006461 (protein complex assembly)
GO:0008152 (metabolic process)
GO:0017148 (negative regulation of translation)
GO:0043039 (tRNA aminoacylation)
GO:0071346 (cellular response to interferon-gamma)
Wikipedia EPRS

Target Cross References - Protein

canSAR P07814
Human Protein Atlas ENSG00000136628
IntAct P07814
Open Targets ENSG00000136628
PharmGKB PA27837
Reactome R-HSA-2408517 (SeMet incorporation into proteins.)
R-HSA-379716 (Cytosolic tRNA aminoacylation.)
R-HSA-6782315 (tRNA modification in the nucleus and cytosol.)
UniProt A0AVA9 B9EGH3 P07814 Q05BP6 Q05DF8 Q5DSM1 Q5H9S5 Q6PD57 Q86X73

Target Cross References - Domain

InterPro IPR000738 (WHEP-TRS_dom.)
IPR000924 (Glu/Gln-tRNA-synth.)
IPR001412 (aa-tRNA-synth_I_CS.)
IPR002314 (aa-tRNA-synt_IIb.)
IPR004046 (GST_C.)
IPR004154 (Anticodon-bd.)
IPR004499 (Pro-tRNA-ligase_IIa_arc-type.)
IPR004526 (Glu-tRNA-synth_arc/euk.)
IPR006195 (aa-tRNA-synth_II.)
IPR009068 (S15_NS1_RNA-bd.)
IPR010987 (Glutathione-S-Trfase_C-like.)
IPR011035 (Ribosomal_L25/Gln-tRNA_synth.)
IPR014729 (Rossmann-like_a/b/a_fold.)
IPR016061 (Pro-tRNA_ligase_II_C.)
IPR017449 (Pro-tRNA_synth_II.)
IPR020056 (Rbsml_L25/Gln-tRNA_synth_b-brl.)
IPR020058 (Glu/Gln-tRNA-synth_Ib_cat-dom.)
IPR020059 (Glu/Gln-tRNA-synth_Ib_codon-bd.)
IPR020061 (Glu/Gln-tRNA-synth_Ib_a-bdl.)
IPR033721 (ProRS_core_arch_euk.)
Pfam PF00043 (GST_C)
PF00458 (WHEP-TRS)
PF00587 (tRNA-synt_2b)
PF00749 (tRNA-synt_1c)
PF03129 (HGTP_anticodon)
PF03950 (tRNA-synt_1c_C)
PF09180 (ProRS-C_1)

Target Cross References - Structure

PDBe 4HVC 4K86 4K87 4K88 5A1N 5A34 5A5H 5BMU
CREDO 4HVC 4K86 4K87 4K88 5A1N 5A34 5A5H 5BMU