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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL3869
Target Type SINGLE PROTEIN
Preferred Name Matrix metalloproteinase 14
Synonyms MMP-14 | MMP-X1 | MMP14 | MT-MMP 1 | MT1-MMP | MT1MMP | MTMMP1 | Matrix metalloproteinase-14 | Membrane-type matrix metalloproteinase 1 | Membrane-type-1 matrix metalloproteinase
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > protease > metallo protease > metallo protease mam clan > metallo protease m10a subfamily

Target Components

Component Description Relationship Accession
Matrix metalloproteinase-14 SINGLE PROTEIN P50281

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000157227
Ensembl ENSG00000157227
GO Cellular Component GO:0005887 (integral to plasma membrane)
GO:0031012 (extracellular matrix)
GO:0042470 (melanosome)
GO Molecular Function GO:0004222 (metalloendopeptidase activity)
GO:0005509 (calcium ion binding)
GO:0008270 (zinc ion binding)
Wikipedia MMP14

Target Cross References - Protein

Human Protein Atlas ENSG00000157227
IntAct P50281
PharmGKB PA30872
UniProt A8K5L0 P50281 Q6GSF3 Q92678

Target Cross References - Domain

InterPro IPR000585 (Hemopexin/matrixin.)
IPR001818 (Pept_M10_metallopeptidase.)
IPR002477 (Peptidoglycan-bd-like.)
IPR006026 (Peptidase_Metallo.)
IPR016293 (Pept_M10A_matrix_strom.)
IPR018486 (Hemopexin/matrixin_CS.)
IPR018487 (Hemopexin/matrixin_repeat.)
IPR021158 (Pept_M10A_Zn_BS.)
IPR021190 (Pept_M10A_matrixin.)
IPR021805 (Pept_M10A_metallopeptidase_C.)
Pfam PF00045 (Hemopexin)
PF00413 (Peptidase_M10)
PF01471 (PG_binding_1)
PF11857 (DUF3377)

Target Cross References - Structure

PDBe 1BQQ 1BUV 3C7X 3MA2
CREDO 1BQQ 1BUV 3C7X 3MA2
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