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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL3867
Target Type SINGLE PROTEIN
Preferred Name Alcohol dehydrogenase class IV
Synonyms ADH7 | Alcohol dehydrogenase class 4 mu/sigma chain | Alcohol dehydrogenase class IV mu/sigma chain | Gastric alcohol dehydrogenase | Retinol dehydrogenase
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
Alcohol dehydrogenase class 4 mu/sigma chain SINGLE PROTEIN P40394

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2096668 Alcohol dehydrogenase PROTEIN FAMILY

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000196344
Ensembl ENSG00000196344
GO Cellular Component GO:0005576 (extracellular region)
GO:0005622 (intracellular)
GO:0005737 (cytoplasm)
GO:0005829 (cytosol)
GO Molecular Function GO:0004022 (alcohol dehydrogenase (NAD) activity)
GO:0004024 (alcohol dehydrogenase activity, zinc-dependent)
GO:0004031 (aldehyde oxidase activity)
GO:0004745 (retinol dehydrogenase activity)
GO:0008270 (zinc ion binding)
GO:0016491 (oxidoreductase activity)
GO:0019841 (retinol binding)
GO:0035276 (ethanol binding)
GO:0046872 (metal ion binding)
GO:0048019 (receptor antagonist activity)
GO Biological Process GO:0001523 (retinoid metabolic process)
GO:0006068 (ethanol catabolic process)
GO:0006069 (ethanol oxidation)
GO:0009617 (response to bacterium)
GO:0010430 (fatty acid omega-oxidation)
GO:0042572 (retinol metabolic process)
GO:0042573 (retinoic acid metabolic process)
GO:0045471 (response to ethanol)
GO:0055114 (oxidation-reduction process)
GO:1900116 (extracellular negative regulation of signal transduction)
Wikipedia ADH7

Target Cross References - Protein

canSAR P40394
Human Protein Atlas ENSG00000196344
Open Targets ENSG00000196344
PharmGKB PA24577
Reactome R-HSA-71384 (Ethanol oxidation.)
UniProt A2RRB6 A8MVN9 B2R760 B4DWV6 P40394 Q13713

Target Cross References - Domain

InterPro IPR002328 (ADH_Zn_CS.)
IPR011032 (GroES-like.)
IPR013149 (ADH_C.)
IPR013154 (ADH_N.)
IPR016040 (NAD(P)-bd_dom.)
Pfam PF00107 (ADH_zinc_N)
PF08240 (ADH_N)

Target Cross References - Structure

PDBe 1AGN 1D1S 1D1T
CREDO 1AGN 1D1S 1D1T
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