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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL3865
Target Type SINGLE PROTEIN
Preferred Name Beta-glucosidase cytosolic
Synonyms CBG | CBGL1 | Cytosolic beta-glucosidase | Cytosolic beta-glucosidase-like protein 1 | GBA3
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
Cytosolic beta-glucosidase SINGLE PROTEIN Q9H227

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

GO Cellular Component GO:0005737 (cytoplasm)
GO:0005829 (cytosol)
GO Molecular Function GO:0004348 (glucosylceramidase activity)
GO:0004553 (hydrolase activity, hydrolyzing O-glycosyl compounds)
GO:0004565 (beta-galactosidase activity)
GO:0008422 (beta-glucosidase activity)
GO:0016787 (hydrolase activity)
GO:0016798 (hydrolase activity, acting on glycosyl bonds)
GO:0017042 (glycosylceramidase activity)
GO:0102483 (scopolin beta-glucosidase activity)
GO Biological Process GO:0005975 (carbohydrate metabolic process)
GO:0006687 (glycosphingolipid metabolic process)
GO:0008152 (metabolic process)
GO:0016139 (glycoside catabolic process)
GO:0046477 (glycosylceramide catabolic process)
Wikipedia GBA3

Target Cross References - Protein

canSAR Q9H227
IntAct Q9H227
Open Targets
PharmGKB PA134861643
Reactome R-HSA-1660662 (Glycosphingolipid metabolism.)
UniProt Q32LY7 Q3MIH4 Q53GG8 Q6NSF4 Q8NHT8 Q9H227 Q9H3T4 Q9H4C6

Target Cross References - Domain

InterPro IPR001360 (Glyco_hydro_1.)
IPR013781 (Glyco_hydro_catalytic_dom.)
IPR017853 (Glycoside_hydrolase_SF.)
IPR033132 (Glyco_hydro_1_N_CS.)
Pfam PF00232 (Glyco_hydro_1)

Target Cross References - Structure

PDBe 2E9L 2E9M 2JFE 2ZOX 3VKK
CREDO 2E9L 2E9M 2JFE 2ZOX 3VKK
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