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Target Report Card

Target Name and Classification

Target ID CHEMBL3864
Target Type SINGLE PROTEIN
Preferred Name Protein-tyrosine phosphatase 2C
Synonyms PTP-1D | PTP-2C | PTP2C | PTPN11 | Protein-tyrosine phosphatase 1D | Protein-tyrosine phosphatase 2C | SH-PTP2 | SH-PTP3 | SHP-2 | SHPTP2 | Shp2 | Tyrosine-protein phosphatase non-receptor type 11
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > phosphatase > protein phosphatase > tyrosine protein phosphatase

Target Components

Component Description Relationship Accession
Tyrosine-protein phosphatase non-receptor type 11 SINGLE PROTEIN Q06124

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000179295
Ensembl ENSG00000179295
GO Cellular Component GO:0005634 (nucleus)
GO:0005737 (cytoplasm)
GO:0005739 (mitochondrion)
GO:0005829 (cytosol)
GO:0043234 (protein complex)
GO Molecular Function GO:0004721 (phosphoprotein phosphatase activity)
GO:0004725 (protein tyrosine phosphatase activity)
GO:0004726 (non-membrane spanning protein tyrosine phosphatase activity)
GO:0005070 (SH3/SH2 adaptor activity)
GO:0005158 (insulin receptor binding)
GO:0005515 (protein binding)
GO:0016303 (1-phosphatidylinositol-3-kinase activity)
GO:0016787 (hydrolase activity)
GO:0016791 (phosphatase activity)
GO:0019904 (protein domain specific binding)
GO:0030971 (receptor tyrosine kinase binding)
GO:0031748 (D1 dopamine receptor binding)
GO:0043274 (phospholipase binding)
GO:0043560 (insulin receptor substrate binding)
GO:0046934 (phosphatidylinositol-4,5-bisphosphate 3-kinase activity)
GO:0051428 (peptide hormone receptor binding)
GO Biological Process GO:0000077 (DNA damage checkpoint)
GO:0000187 (activation of MAPK activity)
GO:0006470 (protein dephosphorylation)
GO:0006629 (lipid metabolic process)
GO:0006641 (triglyceride metabolic process)
GO:0007173 (epidermal growth factor receptor signaling pathway)
GO:0007229 (integrin-mediated signaling pathway)
GO:0007409 (axonogenesis)
GO:0007420 (brain development)
GO:0007507 (heart development)
GO:0008543 (fibroblast growth factor receptor signaling pathway)
GO:0009755 (hormone-mediated signaling pathway)
GO:0009967 (positive regulation of signal transduction)
GO:0014066 (regulation of phosphatidylinositol 3-kinase signaling)
GO:0016311 (dephosphorylation)
GO:0021697 (cerebellar cortex formation)
GO:0030168 (platelet activation)
GO:0030220 (platelet formation)
GO:0031295 (T cell costimulation)
GO:0032528 (microvillus organization)
GO:0033277 (abortive mitotic cell cycle)
GO:0033628 (regulation of cell adhesion mediated by integrin)
GO:0033629 (negative regulation of cell adhesion mediated by integrin)
GO:0035264 (multicellular organism growth)
GO:0035265 (organ growth)
GO:0035335 (peptidyl-tyrosine dephosphorylation)
GO:0035855 (megakaryocyte development)
GO:0036092 (phosphatidylinositol-3-phosphate biosynthetic process)
GO:0036302 (atrioventricular canal development)
GO:0038127 (ERBB signaling pathway)
GO:0040014 (regulation of multicellular organism growth)
GO:0042445 (hormone metabolic process)
GO:0042593 (glucose homeostasis)
GO:0043254 (regulation of protein complex assembly)
GO:0045931 (positive regulation of mitotic cell cycle)
GO:0046676 (negative regulation of insulin secretion)
GO:0046825 (regulation of protein export from nucleus)
GO:0046854 (phosphatidylinositol phosphorylation)
GO:0046887 (positive regulation of hormone secretion)
GO:0046888 (negative regulation of hormone secretion)
GO:0048008 (platelet-derived growth factor receptor signaling pathway)
GO:0048011 (neurotrophin TRK receptor signaling pathway)
GO:0048013 (ephrin receptor signaling pathway)
GO:0048015 (phosphatidylinositol-mediated signaling)
GO:0048609 (multicellular organismal reproductive process)
GO:0048806 (genitalia development)
GO:0048839 (inner ear development)
GO:0048873 (homeostasis of number of cells within a tissue)
GO:0050900 (leukocyte migration)
GO:0051463 (negative regulation of cortisol secretion)
GO:0060020 (Bergmann glial cell differentiation)
GO:0060125 (negative regulation of growth hormone secretion)
GO:0060325 (face morphogenesis)
GO:0060338 (regulation of type I interferon-mediated signaling pathway)
GO:0061582 (intestinal epithelial cell migration)
GO:0070374 (positive regulation of ERK1 and ERK2 cascade)
GO:2001275 (positive regulation of glucose import in response to insulin stimulus)
Wikipedia PTPN11

Target Cross References - Protein

canSAR Q06124
CGD Noonan syndrome; LEOPARD syndrome
Human Protein Atlas ENSG00000179295
IntAct Q06124
Open Targets ENSG00000179295
PharmGKB PA33986
Reactome R-HSA-1059683 (Interleukin-6 signaling.)
R-HSA-109704 (PI3K Cascade.)
R-HSA-110056 (MAPK3 (ERK1) activation.)
R-HSA-112411 (MAPK1 (ERK2) activation.)
R-HSA-114604 (GPVI-mediated activation cascade.)
R-HSA-1170546 (Prolactin receptor signaling.)
R-HSA-1257604 (PIP3 activates AKT signaling.)
R-HSA-1295596 (Spry regulation of FGF signaling.)
R-HSA-1433557 (Signaling by SCF-KIT.)
R-HSA-180292 (GAB1 signalosome.)
R-HSA-186763 (Downstream signal transduction.)
R-HSA-210990 (PECAM1 interactions.)
R-HSA-210993 (Tie2 Signaling.)
R-HSA-2219530 (Constitutive Signaling by Aberrant PI3K in Cancer.)
R-HSA-2586552 (Signaling by Leptin.)
R-HSA-388841 (Costimulation by the CD28 family.)
R-HSA-389513 (CTLA4 inhibitory signaling.)
R-HSA-389948 (PD-1 signaling.)
R-HSA-391160 (Signal regulatory protein (SIRP) family interactions.)
R-HSA-418886 (Netrin mediated repulsion signals.)
R-HSA-432142 (Platelet sensitization by LDL.)
R-HSA-512988 (Interleukin-3, 5 and GM-CSF signaling.)
R-HSA-5654689 (PI-3K cascade:FGFR1.)
R-HSA-5654693 (FRS-mediated FGFR1 signaling.)
R-HSA-5654695 (PI-3K cascade:FGFR2.)
R-HSA-5654700 (FRS-mediated FGFR2 signaling.)
R-HSA-5654706 (FRS-mediated FGFR3 signaling.)
R-HSA-5654710 (PI-3K cascade:FGFR3.)
R-HSA-5654712 (FRS-mediated FGFR4 signaling.)
R-HSA-5654720 (PI-3K cascade:FGFR4.)
R-HSA-5654726 (Negative regulation of FGFR1 signaling.)
R-HSA-5654727 (Negative regulation of FGFR2 signaling.)
R-HSA-5654732 (Negative regulation of FGFR3 signaling.)
R-HSA-5654733 (Negative regulation of FGFR4 signaling.)
R-HSA-6811558 (PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling.)
R-HSA-877312 (Regulation of IFNG signaling.)
R-HSA-8853659 (RET signaling.)
R-HSA-8865999 (MET activates PTPN11.)
R-HSA-909733 (Interferon alpha/beta signaling.)
R-HSA-912694 (Regulation of IFNA signaling.)
R-HSA-936964 (Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon.)
UniProt A8K1D9 Q06124 Q96HD7

Target Cross References - Domain

InterPro IPR000242 (PTPase_domain.)
IPR000387 (TYR_PHOSPHATASE_dom.)
IPR000980 (SH2.)
IPR003595 (Tyr_Pase_cat.)
IPR012152 (Tyr_Pase_non-rcpt_typ-6/11.)
IPR016130 (Tyr_Pase_AS.)
IPR029021 (Prot-tyrosine_phosphatase-like.)
Pfam PF00017 (SH2)
PF00102 (Y_phosphatase)

Target Cross References - Structure

PDBe 2SHP 3B7O 3MOW 3O5X 3TKZ 3TL0 3ZM0 3ZM1 3ZM2 3ZM3 4DGP 4DGX 4GWF 4H1O 4H34 4JE4 4JEG 4JMG 4NWF 4NWG 4OHD 4OHE 4OHH 4OHI More...
CREDO 2SHP 3B7O 3MOW 3O5X 3TKZ 3TL0 3ZM0 3ZM1 3ZM2 3ZM3 4DGP 4DGX 4GWF 4H1O 4H34 4JE4 4JEG 4JMG 4NWF 4NWG 4OHD 4OHE 4OHH 4OHI More...
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