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Target Report Card

Target Name and Classification

Target ID CHEMBL3863
Preferred Name Protein kinase C mu
Synonyms PKD | PKD1 | PRKCM | PRKD1 | Protein kinase C mu type | Protein kinase D | Serine/threonine-protein kinase D1 | nPKC-D1 | nPKC-mu
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > camk protein kinase group > camk protein kinase pkd family

Target Components

Component Description Relationship Accession
Serine/threonine-protein kinase D1 SINGLE PROTEIN Q15139

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2093867 Protein kinase C (PKC) PROTEIN FAMILY
CHEMBL2096620 Protein kinase C, PKC; classical/novel PROTEIN FAMILY

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000184304
Ensembl ENSG00000184304
GO Cellular Component GO:0005634 (nucleus)
GO:0005737 (cytoplasm)
GO:0005794 (Golgi apparatus)
GO:0005802 (trans-Golgi network)
GO:0005829 (cytosol)
GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0005911 (cell-cell junction)
GO:0005938 (cell cortex)
GO:0016020 (membrane)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0004672 (protein kinase activity)
GO:0004674 (protein serine/threonine kinase activity)
GO:0004697 (protein kinase C activity)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0016301 (kinase activity)
GO:0016740 (transferase activity)
GO:0042802 (identical protein binding)
GO:0046872 (metal ion binding)
GO Biological Process GO:0001525 (angiogenesis)
GO:0001938 (positive regulation of endothelial cell proliferation)
GO:0002376 (immune system process)
GO:0006468 (protein phosphorylation)
GO:0006915 (apoptotic process)
GO:0006954 (inflammatory response)
GO:0007030 (Golgi organization)
GO:0007165 (signal transduction)
GO:0007229 (integrin-mediated signaling pathway)
GO:0007265 (Ras protein signal transduction)
GO:0007399 (nervous system development)
GO:0008283 (cell proliferation)
GO:0010595 (positive regulation of endothelial cell migration)
GO:0010837 (regulation of keratinocyte proliferation)
GO:0010976 (positive regulation of neuron projection development)
GO:0016310 (phosphorylation)
GO:0018105 (peptidyl-serine phosphorylation)
GO:0030148 (sphingolipid biosynthetic process)
GO:0030154 (cell differentiation)
GO:0031647 (regulation of protein stability)
GO:0032793 (positive regulation of CREB transcription factor activity)
GO:0033138 (positive regulation of peptidyl-serine phosphorylation)
GO:0034599 (cellular response to oxidative stress)
GO:0035556 (intracellular signal transduction)
GO:0035924 (cellular response to vascular endothelial growth factor stimulus)
GO:0038033 (positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway)
GO:0043123 (positive regulation of I-kappaB kinase/NF-kappaB signaling)
GO:0043536 (positive regulation of blood vessel endothelial cell migration)
GO:0045087 (innate immune response)
GO:0045669 (positive regulation of osteoblast differentiation)
GO:0045766 (positive regulation of angiogenesis)
GO:0045806 (negative regulation of endocytosis)
GO:0045944 (positive regulation of transcription from RNA polymerase II promoter)
GO:0046777 (protein autophosphorylation)
GO:0048010 (vascular endothelial growth factor receptor signaling pathway)
GO:0048193 (Golgi vesicle transport)
GO:0051092 (positive regulation of NF-kappaB transcription factor activity)
GO:0051279 (regulation of release of sequestered calcium ion into cytosol)
GO:0060548 (negative regulation of cell death)
GO:0089700 (protein kinase D signaling)
GO:1901727 (positive regulation of histone deacetylase activity)
GO:2001028 (positive regulation of endothelial cell chemotaxis)
GO:2001044 (regulation of integrin-mediated signaling pathway)
Wikipedia Protein_kinase_D1

Target Cross References - Protein

canSAR Q15139
Human Protein Atlas ENSG00000184304
IntAct Q15139
Guide to Pharmacology 1489
Open Targets ENSG00000184304
PharmGKB PA33771
Pharos Q15139 (Tchem)
Reactome R-HSA-1660661 (Sphingolipid de novo biosynthesis.)
UniProt A6NL64 B2RAF6 Q15139

Target Cross References - Domain

InterPro IPR000719 (Prot_kinase_dom.)
IPR001849 (PH_domain.)
IPR002219 (PE/DAG-bd.)
IPR008271 (Ser/Thr_kinase_AS.)
IPR011009 (Kinase-like_dom.)
IPR011993 (PH_dom-like.)
IPR015727 (Protein_Kinase_C_mu-related.)
IPR017441 (Protein_kinase_ATP_BS.)
IPR020454 (DAG/PE-bd.)
Pfam PF00069 (Pkinase)
PF00130 (C1_1)
PF00169 (PH)