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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL3856162
Target Type SINGLE PROTEIN
Preferred Name Low affinity immunoglobulin gamma Fc region receptor III-A
Synonyms CD16A | CD16a antigen | CD_antigen=CD16a | FCG3 | FCGR3 | FCGR3A | Fc-gamma RIII | Fc-gamma RIII-alpha | Fc-gamma RIIIa | FcR-10 | FcRIII | FcRIIIa | IGFR3 | IgG Fc receptor III-2 | Low affinity immunoglobulin gamma Fc region receptor III-A
Organism Homo sapiens
Species Group No
Protein Target Classification
  • membrane receptor

Target Components

Component Description Relationship Accession
Low affinity immunoglobulin gamma Fc region receptor III-A SINGLE PROTEIN P08637

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL2108581 CATUMAXOMAB Low affinity immunoglobulin gamma Fc region receptor III-A cross-linking agent 4 PubMed
CHEMBL2109389 IMGATUZUMAB Low affinity immunoglobulin gamma Fc region receptor III-A cross-linking agent 2 PubMed PubMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000203747
Ensembl ENSG00000203747
GO Cellular Component GO:0005576 (extracellular region)
GO:0005886 (plasma membrane)
GO:0009897 (external side of plasma membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0070062 (extracellular exosome)
GO Molecular Function GO:0019864 (IgG binding)
GO Biological Process GO:0006955 (immune response)
GO:0038096 (Fc-gamma receptor signaling pathway involved in phagocytosis)
GO:0050776 (regulation of immune response)

Target Cross References - Protein

Human Protein Atlas ENSG00000203747
IntAct P08637
Open Targets ENSG00000203747
Reactome R-HSA-198933 (Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.)
R-HSA-2029481 (FCGR activation.)
R-HSA-2029482 (Regulation of actin dynamics for phagocytic cup formation.)
R-HSA-2029485 (Role of phospholipids in phagocytosis.)
UniProt A2N6W9 P08637 Q53FJ0 Q53FL6 Q5EBR4 Q65ZM6 Q6PIJ0

Target Cross References - Domain

InterPro IPR003599 (Ig_sub.)
IPR007110 (Ig-like_dom.)
IPR013783 (Ig-like_fold.)
IPR036179 (Ig-like_dom_sf.)
Pfam PF13895 (Ig_2)

Target Cross References - Structure

PDBe 3AY4 3SGJ 3SGK 3WN5 5BW7 5D6D 5ML9 5MN2 5XJE 5XJF
CREDO 3AY4 3SGJ 3SGK 3WN5 5BW7 5D6D 5ML9 5MN2 5XJE 5XJF
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