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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL3847
Preferred Name AMP-activated protein kinase, beta-1 subunit
Synonyms 5'-AMP-activated protein kinase subunit beta-1 | AMPK | AMPK subunit beta-1 | AMPKb | PRKAB1
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase regulatory subunit

Target Components

Component Description Relationship Accession
5'-AMP-activated protein kinase subunit beta-1 SINGLE PROTEIN Q9Y478

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL3038452 AMPK alpha1/beta1/gamma3 PROTEIN COMPLEX
CHEMBL3038451 AMPK alpha1/beta1/gamma2 PROTEIN COMPLEX
CHEMBL2111345 AMP-activated protein kinase (AMPK) alpha-1/beta-1/gamma-1 PROTEIN COMPLEX
CHEMBL3038455 AMPK alpha2/beta1/gamma1 PROTEIN COMPLEX
CHEMBL2096907 AMP-activated protein kinase, AMPK PROTEIN COMPLEX GROUP

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000111725
Ensembl ENSG00000111725
GO Cellular Component GO:0005829 (cytosol)
GO Biological Process GO:0006633 (fatty acid biosynthetic process)
GO:0007050 (cell cycle arrest)
GO:0008286 (insulin receptor signaling pathway)
GO:0046320 (regulation of fatty acid oxidation)
Wikipedia PRKAB1

Target Cross References - Protein

canSAR Q9Y478
Human Protein Atlas ENSG00000111725
IntAct Q9Y478
Guide to Pharmacology 1543 (protein kinase, AMP-activated, beta 1 non-catalytic subunit)
PharmGKB PA33746
Reactome REACT_11163 (Activated AMPK stimulates fatty-acid oxidation in muscle.)
REACT_498 (Signaling by Insulin receptor.)
UniProt Q9UBV0 Q9UE20 Q9UEX2 Q9Y478 Q9Y6V8

Target Cross References - Domain

InterPro IPR006828 (AMP_prot_kin_bsu_interact-dom.)
Pfam PF04739 (AMPKBI)