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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL3847
Target Type SINGLE PROTEIN
Preferred Name AMP-activated protein kinase, beta-1 subunit
Synonyms 5'-AMP-activated protein kinase subunit beta-1 | AMPK subunit beta-1 | AMPK | AMPKb | PRKAB1
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase regulatory subunit

Target Components

Component Description Relationship Accession
5'-AMP-activated protein kinase subunit beta-1 SINGLE PROTEIN Q9Y478

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL3038451 AMPK alpha1/beta1/gamma2 PROTEIN COMPLEX
CHEMBL2111345 AMP-activated protein kinase (AMPK) alpha-1/beta-1/gamma-1 PROTEIN COMPLEX
CHEMBL3038452 AMPK alpha1/beta1/gamma3 PROTEIN COMPLEX
CHEMBL3038455 AMPK alpha2/beta1/gamma1 PROTEIN COMPLEX
CHEMBL2096907 AMP-activated protein kinase, AMPK PROTEIN COMPLEX GROUP

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000111725
Ensembl ENSG00000111725
GO Cellular Component GO:0005634 (nucleus)
GO:0005654 (nucleoplasm)
GO:0005829 (cytosol)
GO:0031588 (nucleotide-activated protein kinase complex)
GO:0043234 (protein complex)
GO Molecular Function GO:0004672 (protein kinase activity)
GO:0004679 (AMP-activated protein kinase activity)
GO:0005515 (protein binding)
GO:0019901 (protein kinase binding)
GO Biological Process GO:0006468 (protein phosphorylation)
GO:0006629 (lipid metabolic process)
GO:0006631 (fatty acid metabolic process)
GO:0006633 (fatty acid biosynthetic process)
GO:0007050 (cell cycle arrest)
GO:0007165 (signal transduction)
GO:0010628 (positive regulation of gene expression)
GO:0016236 (macroautophagy)
GO:0045859 (regulation of protein kinase activity)
GO:0050790 (regulation of catalytic activity)
GO:0051291 (protein heterooligomerization)
GO:1901796 (regulation of signal transduction by p53 class mediator)
Wikipedia PRKAB1

Target Cross References - Protein

canSAR Q9Y478
Human Protein Atlas ENSG00000111725
IntAct Q9Y478
Guide to Pharmacology 1543
Open Targets ENSG00000111725
PharmGKB PA33746
Pharos Q9Y478 (Tbio)
Reactome R-HSA-1445148 (Translocation of GLUT4 to the plasma membrane.)
R-HSA-1632852 (Macroautophagy.)
R-HSA-2151209 (Activation of PPARGC1A (PGC-1alpha) by phosphorylation.)
R-HSA-380972 (Energy dependent regulation of mTOR by LKB1-AMPK.)
R-HSA-5628897 (TP53 Regulates Metabolic Genes.)
R-HSA-6804756 (Regulation of TP53 Activity through Phosphorylation.)
UniProt Q9UBV0 Q9UE20 Q9UEX2 Q9Y478 Q9Y6V8

Target Cross References - Domain

InterPro IPR006828 (ASC_dom.)
IPR014756 (Ig_E-set.)
IPR030080 (AMPK_beta-1.)
IPR032640 (AMPK1_CBM.)
Pfam PF04739 (AMPKBI)
PF16561 (AMPK1_CBM)

Target Cross References - Structure

PDBe 4CFE 4CFF 4ZHX 5EZV
CREDO 4CFE 4CFF 4ZHX 5EZV
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