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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL3838
Preferred Name Tubulin beta-4 chain
Synonyms TUBB4 | TUBB4A | TUBB5 | Tubulin 5 beta | Tubulin beta-4 chain | Tubulin beta-4A chain
Organism Homo sapiens
Species Group No
Protein Target Classification
  • structural protein

Target Components

Component Description Relationship Accession
Tubulin beta-4A chain SINGLE PROTEIN P04350

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL3832942 Tubulin beta PROTEIN FAMILY

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000104833
Ensembl ENSG00000104833
GO Cellular Component GO:0005634 (nucleus)
GO:0005737 (cytoplasm)
GO:0005829 (cytosol)
GO:0005856 (cytoskeleton)
GO:0005874 (microtubule)
GO:0005929 (cilium)
GO:0033269 (internode region of axon)
GO:0042995 (cell projection)
GO:0043025 (neuronal cell body)
GO:0043209 (myelin sheath)
GO:0070062 (extracellular exosome)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0003924 (GTPase activity)
GO:0005200 (structural constituent of cytoskeleton)
GO:0005515 (protein binding)
GO:0005525 (GTP binding)
GO Biological Process GO:0000086 (G2/M transition of mitotic cell cycle)
GO:0007017 (microtubule-based process)
Wikipedia TUBB4

Target Cross References - Protein

canSAR P04350
Human Protein Atlas ENSG00000104833
IntAct P04350
Open Targets ENSG00000104833
PharmGKB PA134949465
Reactome R-HSA-1445148 (Translocation of GLUT4 to the plasma membrane.)
R-HSA-190840 (Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane.)
R-HSA-190861 (Gap junction assembly.)
R-HSA-2132295 (MHC class II antigen presentation.)
R-HSA-2467813 (Separation of Sister Chromatids.)
R-HSA-2500257 (Resolution of Sister Chromatid Cohesion.)
R-HSA-2565942 (Regulation of PLK1 Activity at G2/M Transition.)
R-HSA-380259 (Loss of Nlp from mitotic centrosomes.)
R-HSA-380270 (Recruitment of mitotic centrosome proteins and complexes.)
R-HSA-380284 (Loss of proteins required for interphase microtubule organization from the centrosome.)
R-HSA-380320 (Recruitment of NuMA to mitotic centrosomes.)
R-HSA-389957 (Prefoldin mediated transfer of substrate to CCT/TriC.)
R-HSA-389960 (Formation of tubulin folding intermediates by CCT/TriC.)
R-HSA-389977 (Post-chaperonin tubulin folding pathway.)
R-HSA-437239 (Recycling pathway of L1.)
R-HSA-5610787 (Hedgehog 'off' state.)
R-HSA-5617833 (Cilium Assembly.)
R-HSA-5620912 (Anchoring of the basal body to the plasma membrane.)
R-HSA-5620924 (Intraflagellar transport.)
R-HSA-5626467 (RHO GTPases activate IQGAPs.)
R-HSA-5663220 (RHO GTPases Activate Formins.)
R-HSA-6807878 (COPI-mediated anterograde transport.)
R-HSA-6811434 (COPI-dependent Golgi-to-ER retrograde traffic.)
R-HSA-6811436 (COPI-independent Golgi-to-ER retrograde traffic.)
R-HSA-68877 (Mitotic Prometaphase.)
R-HSA-8852276 (The role of GTSE1 in G2/M progression after G2 checkpoint.)
R-HSA-8854518 (AURKA Activation by TPX2.)
R-HSA-983189 (Kinesins.)
UniProt B3KQP4 P04350 Q969E5

Target Cross References - Domain

InterPro IPR000217 (Tubulin.)
IPR002453 (Beta_tubulin.)
IPR003008 (Tubulin_FtsZ_GTPase.)
IPR008280 (Tub_FtsZ_C.)
IPR013838 (Beta-tubulin_BS.)
IPR017975 (Tubulin_CS.)
IPR018316 (Tubulin/FtsZ_2-layer-sand-dom.)
IPR023123 (Tubulin_C.)
Pfam PF00091 (Tubulin)
PF03953 (Tubulin_C)