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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL3837
Preferred Name Cathepsin L
Synonyms CTSL | CTSL1 | Cathepsin L | Cathepsin L1 heavy chain | Cathepsin L1 light chain | Cathepsin L1 | MEP | Major excreted protein
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > protease > cysteine protease > cysteine protease ca clan > cysteine protease c1a family

Target Components

Component Description Relationship Accession
Cathepsin L1 SINGLE PROTEIN P07711

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2111380 Cathepsin (L and K) SELECTIVITY GROUP

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000135047
Ensembl ENSG00000135047
GO Cellular Component GO:0005576 (extracellular region)
GO:0005615 (extracellular space)
GO:0005634 (nucleus)
GO:0005764 (lysosome)
GO:0036021 (endolysosome lumen)
GO:0043202 (lysosomal lumen)
GO:0070062 (extracellular exosome)
GO Molecular Function GO:0001968 (fibronectin binding)
GO:0004197 (cysteine-type endopeptidase activity)
GO:0004252 (serine-type endopeptidase activity)
GO:0005515 (protein binding)
GO:0005518 (collagen binding)
GO:0008233 (peptidase activity)
GO:0008234 (cysteine-type peptidase activity)
GO:0016787 (hydrolase activity)
GO:0042393 (histone binding)
GO:0043394 (proteoglycan binding)
GO:0097655 (serpin family protein binding)
GO Biological Process GO:0002224 (toll-like receptor signaling pathway)
GO:0002250 (adaptive immune response)
GO:0006508 (proteolysis)
GO:0019882 (antigen processing and presentation)
GO:0019886 (antigen processing and presentation of exogenous peptide antigen via MHC class II)
GO:0022617 (extracellular matrix disassembly)
GO:0030574 (collagen catabolic process)
GO:0045616 (regulation of keratinocyte differentiation)
GO:0051603 (proteolysis involved in cellular protein catabolic process)
GO:0071888 (macrophage apoptotic process)
GO:0097067 (cellular response to thyroid hormone stimulus)
Wikipedia Cathepsin_L1

Target Cross References - Protein

canSAR P07711
Human Protein Atlas ENSG00000135047
IntAct P07711
Guide to Pharmacology 2351
Open Targets ENSG00000135047
PharmGKB PA162382890
Reactome R-HSA-1236977 (Endosomal/Vacuolar pathway.)
R-HSA-1442490 (Collagen degradation.)
R-HSA-1474228 (Degradation of the extracellular matrix.)
R-HSA-1679131 (Trafficking and processing of endosomal TLR.)
R-HSA-2022090 (Assembly of collagen fibrils and other multimeric structures.)
R-HSA-2132295 (MHC class II antigen presentation.)
R-HSA-8939242 (RUNX1 regulates transcription of genes involved in differentiation of keratinocytes.)
UniProt P07711 Q6IAV1 Q96QJ0

Target Cross References - Domain

InterPro IPR000169 (Pept_cys_AS.)
IPR000668 (Peptidase_C1A_C.)
IPR013128 (Peptidase_C1A.)
IPR013201 (Prot_inhib_I29.)
IPR025660 (Pept_his_AS.)
IPR025661 (Pept_asp_AS.)
Pfam PF00112 (Peptidase_C1)
PF08246 (Inhibitor_I29)

Target Cross References - Structure

PDBe 1CJL 1CS8 1ICF 1MHW 2NQD 2VHS 2XU1 2XU3 2XU4 2XU5 2YJ2 2YJ8 2YJ9 2YJB 2YJC 3BC3 3H89 3H8B 3H8C 3HHA 3HWN 3IV2 3K24 3KSE More...
CREDO 1CJL 1CS8 1ICF 1MHW 2NQD 2VHS 2XU1 2XU3 2XU4 2XU5 2YJ2 2YJ8 2YJ9 2YJB 2YJC 3BC3 3H89 3H8B 3H8C 3HHA 3HWN 3IV2 3K24 3KSE More...