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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL3837
Target Type SINGLE PROTEIN
Preferred Name Cathepsin L
Synonyms Object
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > protease > cysteine protease > cysteine protease ca clan > cysteine protease c1a family

Target Components

Component Description Relationship Accession
Cathepsin L1 SINGLE PROTEIN P07711

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2111380 Cathepsin (L and K) SELECTIVITY GROUP

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000135047
Ensembl ENSG00000135047
GO Cellular Component GO:0043202 (lysosomal lumen)
GO:0036021 (endolysosome lumen)
GO:0005615 (extracellular space)
GO:0070062 (extracellular exosome)
GO:0005576 (extracellular region)
GO:0005634 (nucleus)
GO:0005764 (lysosome)
GO Molecular Function GO:0042393 (histone binding)
GO:0005518 (collagen binding)
GO:0008234 (cysteine-type peptidase activity)
GO:0097655 (serpin family protein binding)
GO:0043394 (proteoglycan binding)
GO:0004197 (cysteine-type endopeptidase activity)
GO:0001968 (fibronectin binding)
GO Biological Process GO:0097067 (cellular response to thyroid hormone stimulus)
GO:0019882 (antigen processing and presentation)
GO:0019886 (antigen processing and presentation of exogenous peptide antigen via MHC class II)
GO:0022617 (extracellular matrix disassembly)
GO:0030574 (collagen catabolic process)
GO:0051603 (proteolysis involved in cellular protein catabolic process)
GO:0071888 (macrophage apoptotic process)
GO:0030198 (extracellular matrix organization)
GO:0045087 (innate immune response)
GO:0006508 (proteolysis)
GO:0002250 (adaptive immune response)
GO:0002224 (toll-like receptor signaling pathway)
Wikipedia Cathepsin_L1

Target Cross References - Protein

canSAR P07711
Human Protein Atlas ENSG00000135047
IntAct P07711
Guide to Pharmacology 2351 (cathepsin L)
PharmGKB PA162382890
UniProt Q6IAV1 P07711 Q96QJ0

Target Cross References - Domain

InterPro IPR000668 (Peptidase_C1A_C.)
IPR013128 (Peptidase_C1A.)
IPR025661 (Pept_asp_AS.)
IPR013201 (Prot_inhib_I29.)
IPR000169 (Pept_cys_AS.)
IPR025660 (Pept_his_AS.)
Pfam PF00112 (Peptidase_C1)
PF08246 (Inhibitor_I29)

Target Cross References - Structure

PDBe 2YJ8 2YJB 2YJC 3OF9 4AXM 2NQD 2VHS 2YJ2 1CS8 2XU3 3OF8 1ICF 1MHW 2XU4 2XU5 2YJ9 3H8C 3K24 1CJL 3IV2 2XU1 3HHA 3KSE 3H8B More...
CREDO 2YJ8 2YJB 2YJC 3OF9 4AXM 2NQD 2VHS 2YJ2 1CS8 2XU3 3OF8 1ICF 1MHW 2XU4 2XU5 2YJ9 3H8C 3K24 1CJL 3IV2 2XU1 3HHA 3KSE 3H8B More...
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