ChEMBL logo


ChEMBL Statistics
  Loading Statistics...

Target Report Card

Target Name and Classification

Target ID CHEMBL3836
Preferred Name LIM domain kinase 1
Synonyms LIM domain kinase 1 | LIMK | LIMK-1 | LIMK1
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > tkl protein kinase group > tkl protein kinase lisk family > tkl protein kinase limk subfamily

Target Components

Component Description Relationship Accession
LIM domain kinase 1 SINGLE PROTEIN P53667

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000106683
Ensembl ENSG00000106683
GO Cellular Component GO:0005634 (nucleus)
GO:0005654 (nucleoplasm)
GO:0005737 (cytoplasm)
GO:0005794 (Golgi apparatus)
GO:0005829 (cytosol)
GO:0005925 (focal adhesion)
GO:0016020 (membrane)
GO:0043005 (neuron projection)
GO:0044295 (axonal growth cone)
GO:0048471 (perinuclear region of cytoplasm)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0004672 (protein kinase activity)
GO:0004674 (protein serine/threonine kinase activity)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0008270 (zinc ion binding)
GO:0016301 (kinase activity)
GO:0016740 (transferase activity)
GO:0031072 (heat shock protein binding)
GO:0046872 (metal ion binding)
GO:0046982 (protein heterodimerization activity)
GO Biological Process GO:0006468 (protein phosphorylation)
GO:0007165 (signal transduction)
GO:0007266 (Rho protein signal transduction)
GO:0007399 (nervous system development)
GO:0016310 (phosphorylation)
GO:0030036 (actin cytoskeleton organization)
GO:0032233 (positive regulation of actin filament bundle assembly)
GO:0038096 (Fc-gamma receptor signaling pathway involved in phagocytosis)
GO:0045773 (positive regulation of axon extension)
GO:0051444 (negative regulation of ubiquitin-protein transferase activity)
GO:0051496 (positive regulation of stress fiber assembly)
Wikipedia LIMK1

Target Cross References - Protein

canSAR P53667
Human Protein Atlas ENSG00000106683
IntAct P53667
Guide to Pharmacology 2054
Open Targets ENSG00000106683
PharmGKB PA30386
Pharos P53667 (Tchem)
Reactome R-HSA-2029482 (Regulation of actin dynamics for phagocytic cup formation.)
R-HSA-3928662 (EPHB-mediated forward signaling.)
R-HSA-399954 (Sema3A PAK dependent Axon repulsion.)
R-HSA-416572 (Sema4D induced cell migration and growth-cone collapse.)
R-HSA-5627117 (RHO GTPases Activate ROCKs.)
R-HSA-5627123 (RHO GTPases activate PAKs.)
UniProt B7Z6I8 D3DXF4 D3DXF5 O15283 P53667 Q15820 Q15821 Q75MU3 Q9Y5Q1

Target Cross References - Domain

InterPro IPR000719 (Prot_kinase_dom.)
IPR001245 (Ser-Thr/Tyr_kinase_cat_dom.)
IPR001478 (PDZ.)
IPR001781 (Znf_LIM.)
IPR011009 (Kinase-like_dom.)
IPR017441 (Protein_kinase_ATP_BS.)
Pfam PF00412 (LIM)
PF00595 (PDZ)
PF07714 (Pkinase_Tyr)

Target Cross References - Structure

PDBe 3S95 5HVJ 5HVK 5L6W