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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL3835
Target Type SINGLE PROTEIN
Preferred Name Serine/threonine-protein kinase NEK2
Synonyms HSPK 21 | NEK2 | NEK2A | NLK1 | Never in mitosis A-related kinase 2 | NimA-like protein kinase 1 | NimA-related protein kinase 2 | Serine/threonine-protein kinase Nek2
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > other protein kinase group > other protein kinase nek family

Target Components

Component Description Relationship Accession
Serine/threonine-protein kinase Nek2 SINGLE PROTEIN P51955

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000117650
Ensembl ENSG00000117650
GO Cellular Component GO:0000777 (condensed chromosome kinetochore)
GO:0005730 (nucleolus)
GO:0005813 (centrosome)
GO:0005829 (cytosol)
GO Molecular Function GO:0004674 (protein serine/threonine kinase activity)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0019903 (protein phosphatase binding)
GO:0046872 (metal ion binding)
GO Biological Process GO:0000086 (G2/M transition of mitotic cell cycle)
GO:0007088 (regulation of mitosis)
GO:0007126 (meiosis)
GO:0046777 (protein autophosphorylation)
GO:0051299 (centrosome separation)
GO:0051301 (cell division)
Wikipedia NEK2

Target Cross References - Protein

canSAR P51955
Human Protein Atlas ENSG00000117650
IntAct P51955
Guide to Pharmacology 2117 (NIMA-related kinase 2)
PharmGKB PA31546
Reactome REACT_152 (Cell Cycle, Mitotic.)
REACT_8017 (APC-Cdc20 mediated degradation of Nek2A.)
UniProt P51955 Q53FD6 Q5I1Z9 Q5VXZ1 Q6NZX8 Q7Z634 Q86XH2 Q96QN9

Target Cross References - Domain

InterPro IPR000719 (Prot_kinase_cat_dom.)
IPR002290 (Ser/Thr_prot_kinase_dom.)
IPR008271 (Ser/Thr_prot_kinase_AS.)
IPR011009 (Kinase-like_dom.)
IPR017442 (Se/Thr_prot_kinase-like_dom.)
Pfam PF00069 (Pkinase)

Target Cross References - Structure

PDBe 2JAV 2W5A 2W5B 2W5H 2WQO 2XK3 2XK4 2XK6 2XK7 2XK8 2XKC 2XKD 2XKE 2XKF 2XNM 2XNN 2XNO 2XNP
CREDO 2JAV 2W5A 2W5B 2W5H 2WQO 2XK3 2XK4 2XK6 2XK7 2XK8 2XKC 2XKD 2XKE 2XKF 2XNM 2XNN 2XNO 2XNP
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