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Target Report Card

Target Name and Classification

Target ID CHEMBL3835
Preferred Name Serine/threonine-protein kinase NEK2
Synonyms HSPK 21 | NEK2 | NEK2A | NLK1 | Never in mitosis A-related kinase 2 | NimA-like protein kinase 1 | NimA-related protein kinase 2 | Serine/threonine-protein kinase Nek2
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > other protein kinase group > other protein kinase nek family

Target Components

Component Description Relationship Accession
Serine/threonine-protein kinase Nek2 SINGLE PROTEIN P51955

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000117650
Ensembl ENSG00000117650
GO Cellular Component GO:0000775 (chromosome, centromeric region)
GO:0000776 (kinetochore)
GO:0000777 (condensed chromosome kinetochore)
GO:0000794 (condensed nuclear chromosome)
GO:0000922 (spindle pole)
GO:0005634 (nucleus)
GO:0005694 (chromosome)
GO:0005730 (nucleolus)
GO:0005737 (cytoplasm)
GO:0005813 (centrosome)
GO:0005815 (microtubule organizing center)
GO:0005829 (cytosol)
GO:0005856 (cytoskeleton)
GO:0005874 (microtubule)
GO:0030496 (midbody)
GO:0043234 (protein complex)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0004672 (protein kinase activity)
GO:0004674 (protein serine/threonine kinase activity)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0016301 (kinase activity)
GO:0016740 (transferase activity)
GO:0019903 (protein phosphatase binding)
GO:0046872 (metal ion binding)
GO Biological Process GO:0000070 (mitotic sister chromatid segregation)
GO:0000086 (G2/M transition of mitotic cell cycle)
GO:0001824 (blastocyst development)
GO:0006468 (protein phosphorylation)
GO:0007049 (cell cycle)
GO:0007059 (chromosome segregation)
GO:0007067 (mitotic nuclear division)
GO:0007088 (regulation of mitotic nuclear division)
GO:0016310 (phosphorylation)
GO:0032212 (positive regulation of telomere maintenance via telomerase)
GO:0043392 (negative regulation of DNA binding)
GO:0046602 (regulation of mitotic centrosome separation)
GO:0046777 (protein autophosphorylation)
GO:0051225 (spindle assembly)
GO:0051299 (centrosome separation)
GO:0051301 (cell division)
GO:0051321 (meiotic cell cycle)
GO:0051973 (positive regulation of telomerase activity)
GO:0051988 (regulation of attachment of spindle microtubules to kinetochore)
GO:0090307 (mitotic spindle assembly)
GO:1903126 (negative regulation of centriole-centriole cohesion)
GO:1904355 (positive regulation of telomere capping)
Wikipedia NEK2

Target Cross References - Protein

canSAR P51955
Human Protein Atlas ENSG00000117650
IntAct P51955
Guide to Pharmacology 2117
Open Targets ENSG00000117650
PharmGKB PA31546
Pharos P51955 (Tchem)
Reactome R-HSA-179409 (APC-Cdc20 mediated degradation of Nek2A.)
R-HSA-2565942 (Regulation of PLK1 Activity at G2/M Transition.)
R-HSA-380259 (Loss of Nlp from mitotic centrosomes.)
R-HSA-380270 (Recruitment of mitotic centrosome proteins and complexes.)
R-HSA-380284 (Loss of proteins required for interphase microtubule organization from the centrosome.)
R-HSA-5620912 (Anchoring of the basal body to the plasma membrane.)
R-HSA-8854518 (AURKA Activation by TPX2.)
UniProt P51955 Q53FD6 Q5I1Z9 Q5VXZ1 Q6NZX8 Q7Z634 Q86XH2 Q96QN9

Target Cross References - Domain

InterPro IPR000719 (Prot_kinase_dom.)
IPR008271 (Ser/Thr_kinase_AS.)
IPR011009 (Kinase-like_dom.)
Pfam PF00069 (Pkinase)

Target Cross References - Structure

PDBe 2JAV 2W5A 2W5B 2W5H 2WQO 2XK3 2XK4 2XK6 2XK7 2XK8 2XKC 2XKD 2XKE 2XKF 2XNM 2XNN 2XNO 2XNP 4A4X 4AFE 5M51 5M53 5M55 5M57
CREDO 2JAV 2W5A 2W5B 2W5H 2WQO 2XK3 2XK4 2XK6 2XK7 2XK8 2XKC 2XKD 2XKE 2XKF 2XNM 2XNN 2XNO 2XNP 4A4X 4AFE 5M51 5M53 5M55 5M57