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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL3834
Target Type SINGLE PROTEIN
Preferred Name Tyrosine-protein kinase BMX
Synonyms BMX | Bone marrow tyrosine kinase gene in chromosome X protein | Cytoplasmic tyrosine-protein kinase BMX | ETK | Epithelial and endothelial tyrosine kinase | NTK38
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > tk protein kinase group > tyrosine protein kinase tec family

Target Components

Component Description Relationship Accession
Cytoplasmic tyrosine-protein kinase BMX SINGLE PROTEIN P51813

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000102010
Ensembl ENSG00000102010
GO Cellular Component GO:0005829 (cytosol)
GO Molecular Function GO:0004715 (non-membrane spanning protein tyrosine kinase activity)
GO:0004871 (signal transducer activity)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0046872 (metal ion binding)
GO Biological Process GO:0006468 (protein phosphorylation)
GO:0006921 (cellular component disassembly involved in apoptosis)
GO:0007498 (mesoderm development)
GO:0035556 (intracellular signal transduction)
Wikipedia BMX_(gene)

Target Cross References - Protein

canSAR P51813
Human Protein Atlas ENSG00000102010
IntAct P51813
PharmGKB PA25389
Reactome REACT_578 (Apoptosis.)
UniProt A6NIH9 O60564 P51813 Q12871

Target Cross References - Domain

InterPro IPR000719 (Prot_kinase_cat_dom.)
IPR000980 (SH2.)
IPR001245 (Ser-Thr/Tyr-Pkinase.)
IPR001562 (Znf_Btk_motif.)
IPR001849 (Pleckstrin_homology.)
IPR008266 (Tyr_prot_kinase_AS.)
IPR011009 (Kinase-like_dom.)
IPR011993 (PH_type.)
IPR017441 (Protein_kinase_ATP_BS.)
IPR020635 (Tyr_Pkinase_cat_dom.)
Pfam PF00017 (SH2)
PF00169 (PH)
PF00779 (BTK)
PF07714 (Pkinase_Tyr)
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