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Target Report Card

Target Name and Classification

Target ID CHEMBL3834
Target Type SINGLE PROTEIN
Preferred Name Tyrosine-protein kinase BMX
Synonyms BMX | Bone marrow tyrosine kinase gene in chromosome X protein | Cytoplasmic tyrosine-protein kinase BMX | ETK | Epithelial and endothelial tyrosine kinase | NTK38
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > tk protein kinase group > tyrosine protein kinase tec family

Target Components

Component Description Relationship Accession
Cytoplasmic tyrosine-protein kinase BMX SINGLE PROTEIN P51813

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000102010
Ensembl ENSG00000102010
GO Cellular Component GO:0005737 (cytoplasm)
GO:0005829 (cytosol)
GO:0031234 (extrinsic component of cytoplasmic side of plasma membrane)
GO:0032587 (ruffle membrane)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0004672 (protein kinase activity)
GO:0004713 (protein tyrosine kinase activity)
GO:0004715 (non-membrane spanning protein tyrosine kinase activity)
GO:0004871 (signal transducer activity)
GO:0005102 (receptor binding)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0016301 (kinase activity)
GO:0016740 (transferase activity)
GO:0046872 (metal ion binding)
GO Biological Process GO:0001865 (NK T cell differentiation)
GO:0006468 (protein phosphorylation)
GO:0006915 (apoptotic process)
GO:0006921 (cellular component disassembly involved in execution phase of apoptosis)
GO:0007155 (cell adhesion)
GO:0007165 (signal transduction)
GO:0007169 (transmembrane receptor protein tyrosine kinase signaling pathway)
GO:0007498 (mesoderm development)
GO:0016310 (phosphorylation)
GO:0035556 (intracellular signal transduction)
GO:0038083 (peptidyl-tyrosine autophosphorylation)
GO:0042127 (regulation of cell proliferation)
GO:0045087 (innate immune response)
GO:0046777 (protein autophosphorylation)
Wikipedia BMX_(gene)

Target Cross References - Protein

canSAR P51813
Human Protein Atlas ENSG00000102010
IntAct P51813
Guide to Pharmacology 1942
Open Targets ENSG00000102010
PharmGKB PA25389
Pharos P51813 (Tchem)
Reactome R-HSA-111465 (Apoptotic cleavage of cellular proteins.)
R-HSA-1660499 (Synthesis of PIPs at the plasma membrane.)
UniProt A6NIH9 O60564 P51813 Q12871

Target Cross References - Domain

InterPro IPR000719 (Prot_kinase_dom.)
IPR000980 (SH2.)
IPR001245 (Ser-Thr/Tyr_kinase_cat_dom.)
IPR001562 (Znf_Btk_motif.)
IPR001849 (PH_domain.)
IPR008266 (Tyr_kinase_AS.)
IPR011009 (Kinase-like_dom.)
IPR011993 (PH_dom-like.)
IPR017441 (Protein_kinase_ATP_BS.)
IPR020635 (Tyr_kinase_cat_dom.)
IPR028840 (BMX.)
Pfam PF00017 (SH2)
PF00169 (PH)
PF00779 (BTK)
PF07714 (Pkinase_Tyr)

Target Cross References - Structure

PDBe 3SXR 3SXS
CREDO 3SXR 3SXS
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