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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL3831
Target Type SINGLE PROTEIN
Preferred Name MAP/microtubule affinity-regulating kinase 2
Synonyms ELKL motif kinase 1 | EMK-1 | EMK1 | MAP/microtubule affinity-regulating kinase 2 | MARK2 | PAR1 homolog b | PAR1 homolog | Par-1b | Par1b | Serine/threonine-protein kinase MARK2
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > camk protein kinase group > camk protein kinase camk1 family > camk protein kinase mark subfamily

Target Components

Component Description Relationship Accession
Serine/threonine-protein kinase MARK2 SINGLE PROTEIN Q7KZI7

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000072518
Ensembl ENSG00000072518
GO Cellular Component GO:0005737 (cytoplasm)
GO:0005739 (mitochondrion)
GO:0005856 (cytoskeleton)
GO:0005884 (actin filament)
GO:0005886 (plasma membrane)
GO:0016020 (membrane)
GO:0016328 (lateral plasma membrane)
GO:0097427 (microtubule bundle)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0000287 (magnesium ion binding)
GO:0004672 (protein kinase activity)
GO:0004674 (protein serine/threonine kinase activity)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0008289 (lipid binding)
GO:0016301 (kinase activity)
GO:0016740 (transferase activity)
GO:0030295 (protein kinase activator activity)
GO:0044822 (poly(A) RNA binding)
GO:0046872 (metal ion binding)
GO:0050321 (tau-protein kinase activity)
GO Biological Process GO:0000422 (mitophagy)
GO:0001764 (neuron migration)
GO:0006468 (protein phosphorylation)
GO:0007275 (multicellular organism development)
GO:0010976 (positive regulation of neuron projection development)
GO:0016055 (Wnt signaling pathway)
GO:0016310 (phosphorylation)
GO:0018107 (peptidyl-threonine phosphorylation)
GO:0030010 (establishment of cell polarity)
GO:0030154 (cell differentiation)
GO:0032147 (activation of protein kinase activity)
GO:0035556 (intracellular signal transduction)
GO:0045197 (establishment or maintenance of epithelial cell apical/basal polarity)
GO:0046777 (protein autophosphorylation)
GO:0050770 (regulation of axonogenesis)
GO:0051493 (regulation of cytoskeleton organization)
GO:0051646 (mitochondrion localization)
Wikipedia MARK2

Target Cross References - Protein

canSAR Q7KZI7
Human Protein Atlas ENSG00000072518
IntAct Q7KZI7
Guide to Pharmacology 2098
Open Targets ENSG00000072518
PharmGKB PA35047
Pharos Q7KZI7 (Tchem)
UniProt Q15449 Q15524 Q5XGA3 Q68A18 Q7KZI7 Q96HB3 Q96RG0

Target Cross References - Domain

InterPro IPR000719 (Prot_kinase_dom.)
IPR001772 (KA1_dom.)
IPR008271 (Ser/Thr_kinase_AS.)
IPR011009 (Kinase-like_dom.)
IPR015940 (UBA.)
IPR017441 (Protein_kinase_ATP_BS.)
IPR028375 (KA1/Ssp2_C.)
IPR033624 (MARK/par1.)
Pfam PF00069 (Pkinase)
PF00627 (UBA)
PF02149 (KA1)

Target Cross References - Structure

PDBe 3IEC 5EAK
CREDO 3IEC 5EAK
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