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Target Report Card

Target Name and Classification

Target ID CHEMBL3829
Target Type SINGLE PROTEIN
Preferred Name CaM kinase II gamma
Synonyms CAMK | CAMK-II | CAMK2G | CAMKG | CaM kinase II subunit gamma | CaMK-II subunit gamma | Calcium/calmodulin-dependent protein kinase type II subunit gamma
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > camk protein kinase group > camk protein kinase camk2 family

Target Components

Component Description Relationship Accession
Calcium/calmodulin-dependent protein kinase type II subunit gamma SINGLE PROTEIN Q13555

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2097164 CaM kinase II PROTEIN FAMILY

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000148660
Ensembl ENSG00000148660
GO Cellular Component GO:0005654 (nucleoplasm)
GO:0005829 (cytosol)
GO:0005886 (plasma membrane)
GO:0016020 (membrane)
GO:0016529 (sarcoplasmic reticulum)
GO:0030666 (endocytic vesicle membrane)
GO:0033017 (sarcoplasmic reticulum membrane)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0004672 (protein kinase activity)
GO:0004674 (protein serine/threonine kinase activity)
GO:0004683 (calmodulin-dependent protein kinase activity)
GO:0004723 (calcium-dependent protein serine/threonine phosphatase activity)
GO:0005088 (Ras guanyl-nucleotide exchange factor activity)
GO:0005515 (protein binding)
GO:0005516 (calmodulin binding)
GO:0005524 (ATP binding)
GO:0016301 (kinase activity)
GO:0016740 (transferase activity)
GO:0042803 (protein homodimerization activity)
GO Biological Process GO:0000082 (G1/S transition of mitotic cell cycle)
GO:0000165 (MAPK cascade)
GO:0006468 (protein phosphorylation)
GO:0006470 (protein dephosphorylation)
GO:0006816 (calcium ion transport)
GO:0007275 (multicellular organism development)
GO:0007399 (nervous system development)
GO:0014733 (regulation of skeletal muscle adaptation)
GO:0016310 (phosphorylation)
GO:0030073 (insulin secretion)
GO:0030154 (cell differentiation)
GO:0043547 (positive regulation of GTPase activity)
GO:0046777 (protein autophosphorylation)
GO:0051259 (protein oligomerization)
GO:0051924 (regulation of calcium ion transport)
GO:0060333 (interferon-gamma-mediated signaling pathway)
GO:1900034 (regulation of cellular response to heat)
GO:1901897 (regulation of relaxation of cardiac muscle)
Wikipedia CAMK2G

Target Cross References - Protein

canSAR Q13555
Human Protein Atlas ENSG00000148660
IntAct Q13555
Guide to Pharmacology 1557
Open Targets ENSG00000148660
PharmGKB PA93
Pharos Q13555 (Tchem)
Reactome R-HSA-3371571 (HSF1-dependent transactivation.)
R-HSA-399719 (Trafficking of AMPA receptors.)
R-HSA-438066 (Unblocking of NMDA receptor, glutamate binding and activation.)
R-HSA-442729 (CREB phosphorylation through the activation of CaMKII.)
R-HSA-442742 (CREB phosphorylation through the activation of Ras.)
R-HSA-442982 (Ras activation uopn Ca2+ infux through NMDA receptor.)
R-HSA-5576892 (Phase 0 - rapid depolarisation.)
R-HSA-5578775 (Ion homeostasis.)
R-HSA-5673001 (RAF/MAP kinase cascade.)
R-HSA-877300 (Interferon gamma signaling.)
R-HSA-936837 (Ion transport by P-type ATPases.)
UniProt O00561 O15378 Q13279 Q13282 Q13555 Q13556 Q5SQZ3 Q5SQZ4 Q5SWX4 Q7KYX5 Q8N4I3 Q8NIA4

Target Cross References - Domain

InterPro IPR000719 (Prot_kinase_dom.)
IPR008271 (Ser/Thr_kinase_AS.)
IPR011009 (Kinase-like_dom.)
IPR013543 (Ca/CaM-dep_prot_kinase-assoc.)
IPR017441 (Protein_kinase_ATP_BS.)
IPR020636 (Ca/CaM-dep_Ca-dep_prot_Kinase.)
IPR032710 (NTF2-like_dom.)
Pfam PF00069 (Pkinase)
PF08332 (CaMKII_AD)

Target Cross References - Structure

PDBe 2UX0 2V7O
CREDO 2UX0 2V7O
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