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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL3826
Target Type SINGLE PROTEIN
Preferred Name Integrin alpha M
Synonyms CD11 antigen-like family member B | CD11B | CD_antigen=CD11b | CR-3 alpha chain | CR3A | Cell surface glycoprotein MAC-1 subunit alpha | ITGAM | Integrin alpha-M | Leukocyte adhesion receptor MO1 | Neutrophil adherence receptor
Organism Homo sapiens
Species Group No
Protein Target Classification
  • membrane receptor

Target Components

Component Description Relationship Accession
Integrin alpha-M SINGLE PROTEIN P11215

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2111362 Integrin alpha-M/beta-2 PROTEIN COMPLEX

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000169896
Ensembl ENSG00000169896
GO Cellular Component GO:0005615 (extracellular space)
GO:0005886 (plasma membrane)
GO:0008305 (integrin complex)
GO:0009897 (external side of plasma membrane)
GO:0009986 (cell surface)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0034688 (integrin alphaM-beta2 complex)
GO:0035579 (specific granule membrane)
GO:0044853 (plasma membrane raft)
GO:0045121 (membrane raft)
GO:0070062 (extracellular exosome)
GO:0070821 (tertiary granule membrane)
GO Molecular Function GO:0001851 (complement component C3b binding)
GO:0005515 (protein binding)
GO:0031072 (heat shock protein binding)
GO:0046872 (metal ion binding)
GO:0046982 (protein heterodimerization activity)
GO Biological Process GO:0001774 (microglial cell activation)
GO:0002376 (immune system process)
GO:0006911 (phagocytosis, engulfment)
GO:0007155 (cell adhesion)
GO:0007229 (integrin-mediated signaling pathway)
GO:0010668 (ectodermal cell differentiation)
GO:0019221 (cytokine-mediated signaling pathway)
GO:0030198 (extracellular matrix organization)
GO:0032930 (positive regulation of superoxide anion generation)
GO:0034142 (toll-like receptor 4 signaling pathway)
GO:0043312 (neutrophil degranulation)
GO:0043315 (positive regulation of neutrophil degranulation)
GO:0045087 (innate immune response)
GO:0045963 (negative regulation of dopamine metabolic process)
GO:0050900 (leukocyte migration)
GO:0090314 (positive regulation of protein targeting to membrane)
GO:0097242 (amyloid-beta clearance)
GO:0098742 (cell-cell adhesion via plasma-membrane adhesion molecules)
GO:1901216 (positive regulation of neuron death)
GO:1903980 (positive regulation of microglial cell activation)
GO:2000363 (positive regulation of prostaglandin-E synthase activity)
Wikipedia Integrin_alpha_M

Target Cross References - Protein

canSAR P11215
Human Protein Atlas ENSG00000169896
IntAct P11215
Open Targets ENSG00000169896
PharmGKB PA29949
Reactome R-HSA-166016 (Toll Like Receptor 4 (TLR4) Cascade.)
R-HSA-202733 (Cell surface interactions at the vascular wall.)
R-HSA-216083 (Integrin cell surface interactions.)
R-HSA-6785807 (Interleukin-4 and 13 signaling.)
R-HSA-6798695 (Neutrophil degranulation.)
UniProt P11215 Q4VAK0 Q4VAK1 Q4VAK2

Target Cross References - Domain

InterPro IPR000413 (Integrin_alpha.)
IPR002035 (VWF_A.)
IPR013517 (FG-GAP.)
IPR013519 (Int_alpha_beta-p.)
IPR013649 (Integrin_alpha-2.)
IPR018184 (Integrin_alpha_C_CS.)
IPR028994 (Integrin_alpha_N.)
IPR032695 (Integrin_dom_sf.)
IPR036465 (vWFA_dom_sf.)
Pfam PF00092 (VWA)
PF00357 (Integrin_alpha)
PF01839 (FG-GAP)
PF08441 (Integrin_alpha2)

Target Cross References - Structure

PDBe 1BHO 1BHQ 1IDN 1IDO 1JLM 1M1U 1MF7 1N9Z 1NA5 3Q3G 3QA3 4M76 4XW2
CREDO 1BHO 1BHQ 1IDN 1IDO 1JLM 1M1U 1MF7 1N9Z 1NA5 3Q3G 3QA3 4M76 4XW2
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