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Target Report Card

Target Name and Classification

Target ID CHEMBL3810
Target Type SINGLE PROTEIN
Preferred Name Fibronectin
Synonyms Anastellin | CIG | Cold-insoluble globulin | FN | FN1 | Fibronectin | Ugl-Y1 | Ugl-Y2 | Ugl-Y3
Organism Homo sapiens
Species Group No
Protein Target Classification
  • adhesion

Target Components

Component Description Relationship Accession
Fibronectin SINGLE PROTEIN P02751

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL2095222 OCRIPLASMIN Fibronectin proteolytic enzyme 4 DailyMed
CHEMBL2109608 L19IL2 Fibronectin binding agent 3 PubMed
CHEMBL2109412 L19SIP 131I Fibronectin other 2 PubMed
CHEMBL2109589 L19TNFA Fibronectin binding agent 2 PubMed
CHEMBL2109413 AS-1409 Fibronectin binding agent 1 PubMed
CHEMBL2109529 MU-BC-1 Fibronectin binding agent 1 Other
CHEMBL1743060 RADRETUMAB Fibronectin binding agent 0 PubMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000115414
Ensembl ENSG00000115414
GO Cellular Component GO:0005576 (extracellular region)
GO:0005577 (fibrinogen complex)
GO:0005578 (proteinaceous extracellular matrix)
GO:0005604 (basement membrane)
GO:0005605 (basal lamina)
GO:0005615 (extracellular space)
GO:0005788 (endoplasmic reticulum lumen)
GO:0005793 (endoplasmic reticulum-Golgi intermediate compartment)
GO:0016324 (apical plasma membrane)
GO:0031012 (extracellular matrix)
GO:0031093 (platelet alpha granule lumen)
GO:0070062 (extracellular exosome)
GO:0072562 (blood microparticle)
GO Molecular Function GO:0002020 (protease binding)
GO:0005102 (receptor binding)
GO:0005178 (integrin binding)
GO:0005515 (protein binding)
GO:0005518 (collagen binding)
GO:0008022 (protein C-terminus binding)
GO:0008201 (heparin binding)
GO:0016504 (peptidase activator activity)
GO:0019899 (enzyme binding)
GO:0042802 (identical protein binding)
GO:0051087 (chaperone binding)
GO:0097718 (disordered domain specific binding)
GO Biological Process GO:0001525 (angiogenesis)
GO:0001932 (regulation of protein phosphorylation)
GO:0002576 (platelet degranulation)
GO:0006953 (acute-phase response)
GO:0007044 (cell-substrate junction assembly)
GO:0007155 (cell adhesion)
GO:0007160 (cell-matrix adhesion)
GO:0007161 (calcium-independent cell-matrix adhesion)
GO:0008284 (positive regulation of cell proliferation)
GO:0008360 (regulation of cell shape)
GO:0009611 (response to wounding)
GO:0010628 (positive regulation of gene expression)
GO:0010952 (positive regulation of peptidase activity)
GO:0018149 (peptide cross-linking)
GO:0019221 (cytokine-mediated signaling pathway)
GO:0022617 (extracellular matrix disassembly)
GO:0030198 (extracellular matrix organization)
GO:0033622 (integrin activation)
GO:0034446 (substrate adhesion-dependent cell spreading)
GO:0035987 (endodermal cell differentiation)
GO:0042060 (wound healing)
GO:0043687 (post-translational protein modification)
GO:0044267 (cellular protein metabolic process)
GO:0045773 (positive regulation of axon extension)
GO:0048146 (positive regulation of fibroblast proliferation)
GO:0050900 (leukocyte migration)
GO:0051702 (interaction with symbiont)
GO:0052047 (interaction with other organism via secreted substance involved in symbiotic interaction)
GO:0070372 (regulation of ERK1 and ERK2 cascade)
GO:1904237 (positive regulation of substrate-dependent cell migration, cell attachment to substrate)
GO:2001202 (negative regulation of transforming growth factor-beta secretion)
Wikipedia Fibronectin

Target Cross References - Protein

CGD Glomerulopathy with fibronectin deposits 2
Human Protein Atlas ENSG00000115414
IntAct P02751
Open Targets ENSG00000115414
PharmGKB PA28194
Reactome R-HSA-114608 (Platelet degranulation.)
R-HSA-1474228 (Degradation of the extracellular matrix.)
R-HSA-1474244 (Extracellular matrix organization.)
R-HSA-1566977 (Fibronectin matrix formation.)
R-HSA-202733 (Cell surface interactions at the vascular wall.)
R-HSA-2129379 (Molecules associated with elastic fibres.)
R-HSA-216083 (Integrin cell surface interactions.)
R-HSA-3000170 (Syndecan interactions.)
R-HSA-3000171 (Non-integrin membrane-ECM interactions.)
R-HSA-3000178 (ECM proteoglycans.)
R-HSA-354192 (Integrin alphaIIb beta3 signaling.)
R-HSA-354194 (GRB2:SOS provides linkage to MAPK signaling for Integrins.)
R-HSA-372708 (p130Cas linkage to MAPK signaling for integrins.)
R-HSA-381426 (Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs).)
R-HSA-5674135 (MAP2K and MAPK activation.)
R-HSA-6785807 (Interleukin-4 and 13 signaling.)
R-HSA-6802946 (Signaling by moderate kinase activity BRAF mutants.)
R-HSA-6802948 (Signaling by high-kinase activity BRAF mutants.)
R-HSA-6802949 (Signaling by RAS mutants.)
R-HSA-6802952 (Signaling by BRAF and RAF fusions.)
R-HSA-6802955 (Paradoxical activation of RAF signaling by kinase inactive BRAF.)
R-HSA-8874081 (MET activates PTK2 signaling.)
R-HSA-8957275 (Post-translational protein phosphorylation.)
UniProt B7ZLF0 E9PE77 E9PG29 O95609 O95610 P02751 Q14312 Q14325 Q14326 Q17RV7 Q564H7 Q585T2 Q59EH1 Q60FE4 Q68DP8 Q68DP9 Q68DT4 Q6LDP6 Q6MZS0 Q6MZU5 Q6N025 Q6N0A6 Q7Z391 Q86T27 Q8IVI8 Q96KP7 Q96KP8 Q96KP9 Q9H1B8 Q9HAP3 Q9UMK2

Target Cross References - Domain

InterPro IPR000083 (Fibronectin_type1.)
IPR000562 (FN_type2_dom.)
IPR003961 (FN3_dom.)
IPR013783 (Ig-like_fold.)
IPR013806 (Kringle-like.)
IPR036116 (FN3_sf.)
IPR036943 (FN_type2_sf.)
Pfam PF00039 (fn1)
PF00040 (fn2)
PF00041 (fn3)

Target Cross References - Structure

PDBe 1FNA 1FNF 1FNH 2CG6 2CG7 2CK2 2GEE 2OCF 2RKY 2RKZ 2RL0 3CAL 3EJH 3GXE 3M7P 3MQL 3R8Q 3T1W 3ZRZ 4GH7 4JE4 4JEG 4LXO 4MMX More...
CREDO 1FNA 1FNF 1FNH 2CG6 2CG7 2CK2 2GEE 2OCF 2RKY 2RKZ 2RL0 3CAL 3EJH 3GXE 3M7P 3MQL 3R8Q 3T1W 3ZRZ 4GH7 4JE4 4JEG 4LXO 4MMX More...
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