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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL3798
Target Type SINGLE PROTEIN
Preferred Name Calcitonin gene-related peptide type 1 receptor
Synonyms CALCRL | CGRP type 1 receptor | CGRPR | Calcitonin gene-related peptide type 1 receptor | Calcitonin receptor-like receptor
Organism Homo sapiens
Species Group No
Protein Target Classification
  • membrane receptor > family b g protein-coupled receptor > peptide receptor (family b gpcr) > calcitonin-like receptor > calcitonin gene-related peptide receptor

Target Components

Component Description Relationship Accession
Calcitonin gene-related peptide type 1 receptor SINGLE PROTEIN Q16602

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2111191 Adrenomedullin receptor, AM2; CALCRL/RAMP3 PROTEIN COMPLEX
CHEMBL2107838 Calcitonin-gene-related peptide receptor, CALCRL/RAMP1 PROTEIN COMPLEX
CHEMBL2109232 Adrenomedullin receptor AM1; CALCRL/RAMP2 PROTEIN COMPLEX

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000064989
Ensembl ENSG00000064989
GO Cellular Component GO:0005887 (integral to plasma membrane)
Wikipedia CALCRL

Target Cross References - Protein

canSAR Q16602
Human Protein Atlas ENSG00000064989
IntAct Q16602
Guide to Pharmacology 47 (calcitonin receptor-like)
PharmGKB PA26033
Reactome REACT_14797 (Signaling by GPCR.)
UniProt A8K6G5 A8KAD3 Q16602 Q53S02 Q53TS5

Target Cross References - Domain

InterPro IPR000832 (GPCR_2_secretin-like.)
IPR001879 (GPCR_2_extracellular_dom.)
IPR003287 (GCPR_2_calcitonin_rcpt-like.)
IPR003289 (GPCR_2_CGRP1_rcpt.)
IPR017981 (GPCR_2-like.)
IPR017983 (GPCR_2_secretin-like_CS.)
Pfam PF00002 (7tm_2)
PF02793 (HRM)

Target Cross References - Structure

PDBe 3N7P 3N7R 3N7S
CREDO 3N7P 3N7R 3N7S
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