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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL3798
Target Type SINGLE PROTEIN
Preferred Name Calcitonin gene-related peptide type 1 receptor
Synonyms CALCRL | CGRP type 1 receptor | CGRPR | Calcitonin gene-related peptide type 1 receptor | Calcitonin receptor-like receptor
Organism Homo sapiens
Species Group No
Protein Target Classification
  • membrane receptor > family b g protein-coupled receptor > peptide receptor (family b gpcr) > calcitonin-like receptor > calcitonin gene-related peptide receptor

Target Components

Component Description Relationship Accession
Calcitonin gene-related peptide type 1 receptor SINGLE PROTEIN Q16602

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2107838 Calcitonin-gene-related peptide receptor, CALCRL/RAMP1 PROTEIN COMPLEX
CHEMBL2109232 Adrenomedullin receptor AM1; CALCRL/RAMP2 PROTEIN COMPLEX
CHEMBL2111191 Adrenomedullin receptor, AM2; CALCRL/RAMP3 PROTEIN COMPLEX

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL236593 TELCAGEPANT Calcitonin gene-related peptide type 1 receptor antagonist 3 PubMed
CHEMBL2364638 UBROGEPANT Calcitonin gene-related peptide type 1 receptor antagonist 3 Other
CHEMBL207197 OLCEGEPANT Calcitonin gene-related peptide type 1 receptor antagonist 2 PubMed PubMed
CHEMBL1910936 MK3207 Calcitonin gene-related peptide type 1 receptor antagonist 2 PubMed
CHEMBL2105635 DAVALINTIDE Calcitonin gene-related peptide type 1 receptor agonist 2 PubMed
CHEMBL2178422 RIMEGEPANT Calcitonin gene-related peptide type 1 receptor antagonist 2 PubMed
CHEMBL3833329 ERENUMAB Calcitonin gene-related peptide type 1 receptor antagonist 0 PubMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000064989
Ensembl ENSG00000064989
GO Cellular Component GO:0005764 (lysosome)
GO:0005768 (endosome)
GO:0005783 (endoplasmic reticulum)
GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO Molecular Function GO:0001605 (adrenomedullin receptor activity)
GO:0001635 (calcitonin gene-related peptide receptor activity)
GO:0004871 (signal transducer activity)
GO:0004888 (transmembrane signaling receptor activity)
GO:0004930 (G-protein coupled receptor activity)
GO:0004948 (calcitonin receptor activity)
GO:0005515 (protein binding)
GO:0008565 (protein transporter activity)
GO Biological Process GO:0001525 (angiogenesis)
GO:0006171 (cAMP biosynthetic process)
GO:0006816 (calcium ion transport)
GO:0007165 (signal transduction)
GO:0007166 (cell surface receptor signaling pathway)
GO:0007186 (G-protein coupled receptor signaling pathway)
GO:0007187 (G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)
GO:0007189 (adenylate cyclase-activating G-protein coupled receptor signaling pathway)
GO:0007507 (heart development)
GO:0008284 (positive regulation of cell proliferation)
GO:0015031 (protein transport)
GO:0030819 (positive regulation of cAMP biosynthetic process)
GO:0031623 (receptor internalization)
GO:0045986 (negative regulation of smooth muscle contraction)
GO:0048661 (positive regulation of smooth muscle cell proliferation)
GO:0050728 (negative regulation of inflammatory response)
GO:0071329 (cellular response to sucrose stimulus)
Wikipedia CALCRL

Target Cross References - Protein

canSAR Q16602
Human Protein Atlas ENSG00000064989
IntAct Q16602
Guide to Pharmacology 47
Open Targets ENSG00000064989
PharmGKB PA26033
Pharos Q16602 (Tchem)
Reactome R-HSA-418555 (G alpha (s) signalling events.)
R-HSA-419812 (Calcitonin-like ligand receptors.)
UniProt A8K6G5 A8KAD3 Q16602 Q53S02 Q53TS5

Target Cross References - Domain

InterPro IPR000832 (GPCR_2_secretin-like.)
IPR001879 (GPCR_2_extracellular_dom.)
IPR003287 (GCPR_2_calcitonin_rcpt_fam.)
IPR003289 (GPCR_2_CGRP1_rcpt.)
IPR017981 (GPCR_2-like.)
IPR017983 (GPCR_2_secretin-like_CS.)
Pfam PF00002 (7tm_2)
PF02793 (HRM)

Target Cross References - Structure

PDBe 3AQF 3N7P 3N7R 3N7S 4RWF 4RWG
CREDO 3AQF 3N7P 3N7R 3N7S 4RWF 4RWG
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