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Target Report Card

Target Name and Classification

Target ID CHEMBL3797
Preferred Name Serine-protein kinase ATM
Synonyms A-T mutated | ATM | Ataxia telangiectasia mutated | Serine-protein kinase ATM
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > atypical protein kinase group > atypical protein kinase pikk family

Target Components

Component Description Relationship Accession
Serine-protein kinase ATM SINGLE PROTEIN Q13315

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL3885635 Serine-protein kinase ATM/ATR PROTEIN FAMILY

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000149311
Ensembl ENSG00000149311
GO Cellular Component GO:0000781 (chromosome, telomeric region)
GO:0000784 (nuclear chromosome, telomeric region)
GO:0005634 (nucleus)
GO:0005654 (nucleoplasm)
GO:0005730 (nucleolus)
GO:0005737 (cytoplasm)
GO:0005819 (spindle)
GO:0031410 (cytoplasmic vesicle)
GO:1990391 (DNA repair complex)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0003677 (DNA binding)
GO:0004672 (protein kinase activity)
GO:0004674 (protein serine/threonine kinase activity)
GO:0004677 (DNA-dependent protein kinase activity)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0016301 (kinase activity)
GO:0016303 (1-phosphatidylinositol-3-kinase activity)
GO:0016740 (transferase activity)
GO:0044877 (macromolecular complex binding)
GO:0046983 (protein dimerization activity)
GO:0047485 (protein N-terminus binding)
GO Biological Process GO:0000077 (DNA damage checkpoint)
GO:0000723 (telomere maintenance)
GO:0000724 (double-strand break repair via homologous recombination)
GO:0000729 (DNA double-strand break processing)
GO:0000731 (DNA synthesis involved in DNA repair)
GO:0000732 (strand displacement)
GO:0001541 (ovarian follicle development)
GO:0001666 (response to hypoxia)
GO:0001756 (somitogenesis)
GO:0002331 (pre-B cell allelic exclusion)
GO:0002376 (immune system process)
GO:0002377 (immunoglobulin production)
GO:0006260 (DNA replication)
GO:0006281 (DNA repair)
GO:0006303 (double-strand break repair via nonhomologous end joining)
GO:0006468 (protein phosphorylation)
GO:0006915 (apoptotic process)
GO:0006974 (cellular response to DNA damage stimulus)
GO:0006975 (DNA damage induced protein phosphorylation)
GO:0006977 (DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest)
GO:0007049 (cell cycle)
GO:0007050 (cell cycle arrest)
GO:0007094 (mitotic spindle assembly checkpoint)
GO:0007131 (reciprocal meiotic recombination)
GO:0007140 (male meiosis)
GO:0007143 (female meiotic division)
GO:0007165 (signal transduction)
GO:0007292 (female gamete generation)
GO:0007420 (brain development)
GO:0007507 (heart development)
GO:0008340 (determination of adult lifespan)
GO:0008585 (female gonad development)
GO:0008630 (intrinsic apoptotic signaling pathway in response to DNA damage)
GO:0009791 (post-embryonic development)
GO:0010212 (response to ionizing radiation)
GO:0010506 (regulation of autophagy)
GO:0016310 (phosphorylation)
GO:0016572 (histone phosphorylation)
GO:0018105 (peptidyl-serine phosphorylation)
GO:0030889 (negative regulation of B cell proliferation)
GO:0032210 (regulation of telomere maintenance via telomerase)
GO:0032212 (positive regulation of telomere maintenance via telomerase)
GO:0033129 (positive regulation of histone phosphorylation)
GO:0033151 (V(D)J recombination)
GO:0035264 (multicellular organism growth)
GO:0036092 (phosphatidylinositol-3-phosphate biosynthetic process)
GO:0036289 (peptidyl-serine autophosphorylation)
GO:0042159 (lipoprotein catabolic process)
GO:0042981 (regulation of apoptotic process)
GO:0043065 (positive regulation of apoptotic process)
GO:0043517 (positive regulation of DNA damage response, signal transduction by p53 class mediator)
GO:0043525 (positive regulation of neuron apoptotic process)
GO:0045141 (meiotic telomere clustering)
GO:0046777 (protein autophosphorylation)
GO:0048538 (thymus development)
GO:0048599 (oocyte development)
GO:0051402 (neuron apoptotic process)
GO:0051726 (regulation of cell cycle)
GO:0051972 (regulation of telomerase activity)
GO:0070192 (chromosome organization involved in meiotic cell cycle)
GO:0071044 (histone mRNA catabolic process)
GO:0071480 (cellular response to gamma radiation)
GO:0071481 (cellular response to X-ray)
GO:0071500 (cellular response to nitrosative stress)
GO:0072434 (signal transduction involved in mitotic G2 DNA damage checkpoint)
GO:0090399 (replicative senescence)
GO:0097694 (establishment of RNA localization to telomere)
GO:0097695 (establishment of macromolecular complex localization to telomere)
GO:1900034 (regulation of cellular response to heat)
GO:1901216 (positive regulation of neuron death)
GO:1901796 (regulation of signal transduction by p53 class mediator)
GO:1903626 (positive regulation of DNA catabolic process)
GO:1903978 (regulation of microglial cell activation)
GO:1904262 (negative regulation of TORC1 signaling)
GO:1904354 (negative regulation of telomere capping)
GO:1904358 (positive regulation of telomere maintenance via telomere lengthening)
GO:1904884 (positive regulation of telomerase catalytic core complex assembly)
GO:1905843 (regulation of cellular response to gamma radiation)
GO:2001022 (positive regulation of response to DNA damage stimulus)
Wikipedia Ataxia_telangiectasia_mutated

Target Cross References - Protein

CGD Ataxia-Telangiectasia
Human Protein Atlas ENSG00000149311
IntAct Q13315
Guide to Pharmacology 1934
Open Targets ENSG00000149311
PharmGKB PA61
Pharos Q13315 (Tchem)
Reactome R-HSA-2559586 (DNA Damage/Telomere Stress Induced Senescence.)
R-HSA-3371453 (Regulation of HSF1-mediated heat shock response.)
R-HSA-349425 (Autodegradation of the E3 ubiquitin ligase COP1.)
R-HSA-5685938 (HDR through Single Strand Annealing (SSA).)
R-HSA-5685942 (HDR through Homologous Recombination (HRR).)
R-HSA-5693548 (Sensing of DNA Double Strand Breaks.)
R-HSA-5693554 (Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA).)
R-HSA-5693565 (Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks.)
R-HSA-5693568 (Resolution of D-loop Structures through Holliday Junction Intermediates.)
R-HSA-5693571 (Nonhomologous End-Joining (NHEJ).)
R-HSA-5693579 (Homologous DNA Pairing and Strand Exchange.)
R-HSA-5693607 (Processing of DNA double-strand break ends.)
R-HSA-5693616 (Presynaptic phase of homologous DNA pairing and strand exchange.)
R-HSA-6796648 (TP53 Regulates Transcription of DNA Repair Genes.)
R-HSA-6803204 (TP53 Regulates Transcription of Genes Involved in Cytochrome C Release.)
R-HSA-6803207 (TP53 Regulates Transcription of Caspase Activators and Caspases.)
R-HSA-6804756 (Regulation of TP53 Activity through Phosphorylation.)
R-HSA-6804757 (Regulation of TP53 Degradation.)
R-HSA-6804760 (Regulation of TP53 Activity through Methylation.)
R-HSA-69473 (G2/M DNA damage checkpoint.)
R-HSA-69541 (Stabilization of p53.)
R-HSA-69601 (Ubiquitin Mediated Degradation of Phosphorylated Cdc25A.)
R-HSA-912446 (Meiotic recombination.)
UniProt B2RNX5 O15429 Q12758 Q13315 Q16551 Q93007 Q9NP02 Q9UCX7

Target Cross References - Domain

InterPro IPR000403 (PI3/4_kinase_cat_dom.)
IPR003151 (PIK-rel_kinase_FAT.)
IPR003152 (FATC_dom.)
IPR011009 (Kinase-like_dom_sf.)
IPR014009 (PIK_FAT.)
IPR015519 (ATM.)
IPR016024 (ARM-type_fold.)
IPR018936 (PI3/4_kinase_CS.)
IPR021668 (TAN.)
IPR036940 (PI3/4_kinase_cat_sf.)
Pfam PF00454 (PI3_PI4_kinase)
PF02259 (FAT)
PF02260 (FATC)
PF11640 (TAN)