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Target Report Card

Target Name and Classification

Target ID CHEMBL3795
Preferred Name Melanocortin receptor 1
Synonyms MC1-R | MC1R | MSH-R | MSHR | Melanocortin receptor 1 | Melanocyte-stimulating hormone receptor
Organism Homo sapiens
Species Group No
Protein Target Classification
  • membrane receptor > family a g protein-coupled receptor > peptide receptor (family a gpcr) > short peptide receptor (family a gpcr) > melanocortin receptor

Target Components

Component Description Relationship Accession
Melanocyte-stimulating hormone receptor SINGLE PROTEIN Q01726

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2111423 Melanocortin receptor (M1 and M4) SELECTIVITY GROUP

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL2070241 BREMELANOTIDE Melanocortin receptor 1 agonist 3 PubMed PubMed
CHEMBL3545104 Modimelanotide Melanocortin receptor 1 agonist 2 PubMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000258839
Ensembl ENSG00000258839
GO Cellular Component GO:0005622 (intracellular)
GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO Molecular Function GO:0004871 (signal transducer activity)
GO:0004930 (G-protein coupled receptor activity)
GO:0004977 (melanocortin receptor activity)
GO:0004980 (melanocyte-stimulating hormone receptor activity)
GO:0005515 (protein binding)
GO:0008528 (G-protein coupled peptide receptor activity)
GO:0031625 (ubiquitin protein ligase binding)
GO Biological Process GO:0007165 (signal transduction)
GO:0007186 (G-protein coupled receptor signaling pathway)
GO:0007187 (G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)
GO:0007275 (multicellular organism development)
GO:0009650 (UV protection)
GO:0010739 (positive regulation of protein kinase A signaling)
GO:0019233 (sensory perception of pain)
GO:0030819 (positive regulation of cAMP biosynthetic process)
GO:0032720 (negative regulation of tumor necrosis factor production)
GO:0035556 (intracellular signal transduction)
GO:0042438 (melanin biosynthetic process)
GO:0043473 (pigmentation)
GO:0045944 (positive regulation of transcription from RNA polymerase II promoter)
GO:0051897 (positive regulation of protein kinase B signaling)
GO:0070914 (UV-damage excision repair)
GO:0090037 (positive regulation of protein kinase C signaling)
Wikipedia Melanocortin_1_receptor

Target Cross References - Protein

canSAR Q01726
CGD Increased analgesia from kappa-opioid receptor agonist, female specific
Human Protein Atlas ENSG00000258839
IntAct Q01726
Guide to Pharmacology 282
Open Targets ENSG00000258839
PharmGKB PA30673
Pharos Q01726 (Tclin)
Reactome R-HSA-375276 (Peptide ligand-binding receptors.)
R-HSA-418555 (G alpha (s) signalling events.)
UniProt Q01726 Q66K38 Q6UR93 Q8WWX6 Q8WWX7 Q96I33 Q96RU4 Q9UBF7 Q9UN58 Q9UN59 Q9UN60 Q9UN61 Q9UN62

Target Cross References - Domain

InterPro IPR000276 (GPCR_Rhodpsn.)
IPR000761 (MSH_rcpt.)
IPR001671 (Melcrt_ACTH_rcpt.)
IPR017452 (GPCR_Rhodpsn_7TM.)
Pfam PF00001 (7tm_1)