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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL3788
Target Type SINGLE PROTEIN
Preferred Name Serine/threonine-protein kinase PLK4
Synonyms PLK-4 | PLK4 | Polo-like kinase 4 | SAK | STK18 | Serine/threonine-protein kinase 18 | Serine/threonine-protein kinase PLK4 | Serine/threonine-protein kinase Sak
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > other protein kinase group > other protein kinase plk family

Target Components

Component Description Relationship Accession
Serine/threonine-protein kinase PLK4 SINGLE PROTEIN O00444

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL1980391 RG-1530 Serine/threonine-protein kinase PLK4 inhibitor 1 PubMed PubMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000142731
Ensembl ENSG00000142731
GO Cellular Component GO:0001741 (XY body)
GO:0005634 (nucleus)
GO:0005730 (nucleolus)
GO:0005737 (cytoplasm)
GO:0005813 (centrosome)
GO:0005814 (centriole)
GO:0005829 (cytosol)
GO:0005856 (cytoskeleton)
GO:0032154 (cleavage furrow)
GO:0098536 (deuterosome)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0004672 (protein kinase activity)
GO:0004674 (protein serine/threonine kinase activity)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0016301 (kinase activity)
GO:0016740 (transferase activity)
GO:0042802 (identical protein binding)
GO Biological Process GO:0000086 (G2/M transition of mitotic cell cycle)
GO:0006468 (protein phosphorylation)
GO:0007099 (centriole replication)
GO:0016310 (phosphorylation)
GO:0046601 (positive regulation of centriole replication)
GO:0060707 (trophoblast giant cell differentiation)
GO:0098535 (de novo centriole assembly)
Wikipedia PLK4

Target Cross References - Protein

canSAR O00444
Human Protein Atlas ENSG00000142731
IntAct O00444
Guide to Pharmacology 2171
Open Targets ENSG00000142731
PharmGKB PA36205
Pharos O00444 (Tchem)
Reactome R-HSA-2565942 (Regulation of PLK1 Activity at G2/M Transition.)
R-HSA-380259 (Loss of Nlp from mitotic centrosomes.)
R-HSA-380270 (Recruitment of mitotic centrosome proteins and complexes.)
R-HSA-380284 (Loss of proteins required for interphase microtubule organization from the centrosome.)
R-HSA-5620912 (Anchoring of the basal body to the plasma membrane.)
R-HSA-8854518 (AURKA Activation by TPX2.)
UniProt B2RAL0 B7Z837 B7Z8G7 O00444 Q8IYF0 Q96Q95 Q9UD84 Q9UDE2

Target Cross References - Domain

InterPro IPR000719 (Prot_kinase_dom.)
IPR000959 (POLO_box_dom.)
IPR008266 (Tyr_kinase_AS.)
IPR011009 (Kinase-like_dom.)
IPR017441 (Protein_kinase_ATP_BS.)
IPR033696 (POLO_box_Plk4_C.)
IPR033698 (POLO_box_Plk4_2.)
IPR033699 (POLO_box_Plk4_1.)
IPR033700 (Plk4.)
Pfam PF00069 (Pkinase)
PF00659 (POLO_box)

Target Cross References - Structure

PDBe 3COK 4JXF 4N7V 4N7Z 4N9J 4YUR 4YYP
CREDO 3COK 4JXF 4N7V 4N7Z 4N9J 4YUR 4YYP
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