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Target Report Card

Target Name and Classification

Target ID CHEMBL3784
Preferred Name Histone acetyltransferase p300
Synonyms E1A-associated protein p300 | EP300 | Histone acetyltransferase p300 | P300 | p300 HAT
Organism Homo sapiens
Species Group No
Protein Target Classification
  • epigenetic regulator > writer > histone acetyltransferase > p300/cbp family
  • epigenetic regulator > reader > bromodomain

Target Components

Component Description Relationship Accession
Histone acetyltransferase p300 SINGLE PROTEIN Q09472

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000100393
Ensembl ENSG00000100393
GO Cellular Component GO:0000123 (histone acetyltransferase complex)
GO:0000785 (chromatin)
GO:0005634 (nucleus)
GO:0005654 (nucleoplasm)
GO:0005667 (transcription factor complex)
GO:0005737 (cytoplasm)
GO:0032993 (protein-DNA complex)
GO Molecular Function GO:0000978 (RNA polymerase II core promoter proximal region sequence-specific DNA binding)
GO:0000979 (RNA polymerase II core promoter sequence-specific DNA binding)
GO:0001047 (core promoter binding)
GO:0001085 (RNA polymerase II transcription factor binding)
GO:0001102 (RNA polymerase II activating transcription factor binding)
GO:0001159 (core promoter proximal region DNA binding)
GO:0001228 (transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding)
GO:0002039 (p53 binding)
GO:0003677 (DNA binding)
GO:0003682 (chromatin binding)
GO:0003684 (damaged DNA binding)
GO:0003700 (transcription factor activity, sequence-specific DNA binding)
GO:0003712 (transcription cofactor activity)
GO:0003713 (transcription coactivator activity)
GO:0003823 (antigen binding)
GO:0004402 (histone acetyltransferase activity)
GO:0004468 (lysine N-acetyltransferase activity, acting on acetyl phosphate as donor)
GO:0005515 (protein binding)
GO:0008013 (beta-catenin binding)
GO:0008022 (protein C-terminus binding)
GO:0008134 (transcription factor binding)
GO:0008270 (zinc ion binding)
GO:0016407 (acetyltransferase activity)
GO:0016740 (transferase activity)
GO:0016746 (transferase activity, transferring acyl groups)
GO:0019901 (protein kinase binding)
GO:0031490 (chromatin DNA binding)
GO:0032403 (protein complex binding)
GO:0033613 (activating transcription factor binding)
GO:0034212 (peptide N-acetyltransferase activity)
GO:0035257 (nuclear hormone receptor binding)
GO:0035259 (glucocorticoid receptor binding)
GO:0042975 (peroxisome proliferator activated receptor binding)
GO:0043425 (bHLH transcription factor binding)
GO:0046332 (SMAD binding)
GO:0046872 (metal ion binding)
GO:0050681 (androgen receptor binding)
GO:0051019 (mitogen-activated protein kinase binding)
GO:0051059 (NF-kappaB binding)
GO:0097157 (pre-mRNA intronic binding)
GO:1990405 (protein antigen binding)
GO Biological Process GO:0000122 (negative regulation of transcription from RNA polymerase II promoter)
GO:0001666 (response to hypoxia)
GO:0001756 (somitogenesis)
GO:0001889 (liver development)
GO:0001934 (positive regulation of protein phosphorylation)
GO:0002223 (stimulatory C-type lectin receptor signaling pathway)
GO:0006283 (transcription-coupled nucleotide-excision repair)
GO:0006351 (transcription, DNA-templated)
GO:0006355 (regulation of transcription, DNA-templated)
GO:0006366 (transcription from RNA polymerase II promoter)
GO:0006473 (protein acetylation)
GO:0006475 (internal protein amino acid acetylation)
GO:0006915 (apoptotic process)
GO:0006977 (DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest)
GO:0006990 (positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response)
GO:0007049 (cell cycle)
GO:0007219 (Notch signaling pathway)
GO:0007399 (nervous system development)
GO:0007507 (heart development)
GO:0007519 (skeletal muscle tissue development)
GO:0007613 (memory)
GO:0007623 (circadian rhythm)
GO:0009749 (response to glucose)
GO:0009887 (organ morphogenesis)
GO:0010506 (regulation of autophagy)
GO:0010560 (positive regulation of glycoprotein biosynthetic process)
GO:0010628 (positive regulation of gene expression)
GO:0010942 (positive regulation of cell death)
GO:0014070 (response to organic cyclic compound)
GO:0014737 (positive regulation of muscle atrophy)
GO:0016032 (viral process)
GO:0016573 (histone acetylation)
GO:0018076 (N-terminal peptidyl-lysine acetylation)
GO:0018393 (internal peptidyl-lysine acetylation)
GO:0030183 (B cell differentiation)
GO:0030220 (platelet formation)
GO:0030307 (positive regulation of cell growth)
GO:0030324 (lung development)
GO:0031324 (negative regulation of cellular metabolic process)
GO:0031325 (positive regulation of cellular metabolic process)
GO:0032025 (response to cobalt ion)
GO:0032092 (positive regulation of protein binding)
GO:0032481 (positive regulation of type I interferon production)
GO:0032526 (response to retinoic acid)
GO:0032967 (positive regulation of collagen biosynthetic process)
GO:0033160 (positive regulation of protein import into nucleus, translocation)
GO:0034612 (response to tumor necrosis factor)
GO:0034644 (cellular response to UV)
GO:0035066 (positive regulation of histone acetylation)
GO:0035690 (cellular response to drug)
GO:0035855 (megakaryocyte development)
GO:0035984 (cellular response to trichostatin A)
GO:0042493 (response to drug)
GO:0042542 (response to hydrogen peroxide)
GO:0042771 (intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)
GO:0043154 (negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)
GO:0043388 (positive regulation of DNA binding)
GO:0043491 (protein kinase B signaling)
GO:0043627 (response to estrogen)
GO:0043923 (positive regulation by host of viral transcription)
GO:0043966 (histone H3 acetylation)
GO:0043967 (histone H4 acetylation)
GO:0043969 (histone H2B acetylation)
GO:0045444 (fat cell differentiation)
GO:0045471 (response to ethanol)
GO:0045727 (positive regulation of translation)
GO:0045773 (positive regulation of axon extension)
GO:0045793 (positive regulation of cell size)
GO:0045815 (positive regulation of gene expression, epigenetic)
GO:0045862 (positive regulation of proteolysis)
GO:0045893 (positive regulation of transcription, DNA-templated)
GO:0045944 (positive regulation of transcription from RNA polymerase II promoter)
GO:0048511 (rhythmic process)
GO:0048565 (digestive tract development)
GO:0050714 (positive regulation of protein secretion)
GO:0050821 (protein stabilization)
GO:0051091 (positive regulation of sequence-specific DNA binding transcription factor activity)
GO:0051592 (response to calcium ion)
GO:0051726 (regulation of cell cycle)
GO:0060177 (regulation of angiotensin metabolic process)
GO:0060298 (positive regulation of sarcomere organization)
GO:0060548 (negative regulation of cell death)
GO:0060765 (regulation of androgen receptor signaling pathway)
GO:0061418 (regulation of transcription from RNA polymerase II promoter in response to hypoxia)
GO:0065004 (protein-DNA complex assembly)
GO:0070301 (cellular response to hydrogen peroxide)
GO:0070542 (response to fatty acid)
GO:0071236 (cellular response to antibiotic)
GO:0071300 (cellular response to retinoic acid)
GO:0071320 (cellular response to cAMP)
GO:0071333 (cellular response to glucose stimulus)
GO:0071389 (cellular response to mineralocorticoid stimulus)
GO:0071407 (cellular response to organic cyclic compound)
GO:0071548 (response to dexamethasone)
GO:0071549 (cellular response to dexamethasone stimulus)
GO:0090043 (regulation of tubulin deacetylation)
GO:1900034 (regulation of cellular response to heat)
GO:1901796 (regulation of signal transduction by p53 class mediator)
GO:1901985 (positive regulation of protein acetylation)
GO:1904837 (beta-catenin-TCF complex assembly)
GO:1990090 (cellular response to nerve growth factor stimulus)
GO:2000629 (negative regulation of miRNA metabolic process)
Wikipedia EP300

Target Cross References - Protein

canSAR Q09472
CGD Rubinstein-Taybi syndrome
Human Protein Atlas ENSG00000100393
IntAct Q09472
Guide to Pharmacology 2735
Open Targets ENSG00000100393
PharmGKB PA27807
Reactome R-HSA-1234158 (Regulation of gene expression by Hypoxia-inducible Factor.)
R-HSA-1368082 (RORA activates gene expression.)
R-HSA-1368108 (BMAL1:CLOCK,NPAS2 activates circadian gene expression.)
R-HSA-156711 (Polo-like kinase mediated events.)
R-HSA-1912408 (Pre-NOTCH Transcription and Translation.)
R-HSA-1989781 (PPARA activates gene expression.)
R-HSA-201722 (Formation of the beta-catenin:TCF transactivating complex.)
R-HSA-2122947 (NOTCH1 Intracellular Domain Regulates Transcription.)
R-HSA-2197563 (NOTCH2 intracellular domain regulates transcription.)
R-HSA-2644606 (Constitutive Signaling by NOTCH1 PEST Domain Mutants.)
R-HSA-2894862 (Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants.)
R-HSA-3134973 (LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production.)
R-HSA-3214847 (HATs acetylate histones.)
R-HSA-3371568 (Attenuation phase.)
R-HSA-381340 (Transcriptional regulation of white adipocyte differentiation.)
R-HSA-400253 (Circadian Clock.)
R-HSA-5250924 (B-WICH complex positively regulates rRNA expression.)
R-HSA-5617472 (Activation of anterior HOX genes in hindbrain development during early embryogenesis.)
R-HSA-5621575 (CD209 (DC-SIGN) signaling.)
R-HSA-5689901 (Metalloprotease DUBs.)
R-HSA-6781823 (Formation of TC-NER Pre-Incision Complex.)
R-HSA-6781827 (Transcription-Coupled Nucleotide Excision Repair (TC-NER).)
R-HSA-6782135 (Dual incision in TC-NER.)
R-HSA-6782210 (Gap-filling DNA repair synthesis and ligation in TC-NER.)
R-HSA-6804114 (TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest.)
R-HSA-6804758 (Regulation of TP53 Activity through Acetylation.)
R-HSA-6804760 (Regulation of TP53 Activity through Methylation.)
R-HSA-6811555 (PI5P Regulates TP53 Acetylation.)
R-HSA-8866907 (Activation of the TFAP2 (AP-2) family of transcription factors.)
R-HSA-918233 (TRAF3-dependent IRF activation pathway.)
R-HSA-933541 (TRAF6 mediated IRF7 activation.)
R-HSA-983231 (Factors involved in megakaryocyte development and platelet production.)
UniProt B1AKC2 Q09472

Target Cross References - Domain

InterPro IPR000197 (Znf_TAZ.)
IPR000433 (Znf_ZZ.)
IPR001487 (Bromodomain.)
IPR003101 (KIX_dom.)
IPR009110 (Nuc_rcpt_coact.)
IPR010303 (RING_CBP-p300.)
IPR013178 (Histone_AcTrfase_Rtt109/CBP.)
IPR014744 (Nuc_rcpt_coact_CREBbp.)
IPR018359 (Bromodomain_CS.)
IPR031162 (CBP_P300_HAT.)
Pfam PF00439 (Bromodomain)
PF00569 (ZZ)
PF02135 (zf-TAZ)
PF02172 (KIX)
PF06001 (DUF902)
PF08214 (HAT_KAT11)
PF09030 (Creb_binding)

Target Cross References - Structure