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Target Report Card

Target Name and Classification

Target ID CHEMBL3784
Target Type SINGLE PROTEIN
Preferred Name Histone acetyltransferase p300
Synonyms E1A-associated protein p300 | EP300 | Histone acetyltransferase p300 | P300 | p300 HAT
Organism Homo sapiens
Species Group No
Protein Target Classification
  • epigenetic regulator > writer > histone acetyltransferase > p300/cbp family
  • epigenetic regulator > reader > bromodomain

Target Components

Component Description Relationship Accession
Histone acetyltransferase p300 SINGLE PROTEIN Q09472

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000100393
Ensembl ENSG00000100393
GO Cellular Component GO:0000123 (histone acetyltransferase complex)
GO:0000785 (chromatin)
GO:0005634 (nucleus)
GO:0005654 (nucleoplasm)
GO:0005667 (transcription factor complex)
GO:0005737 (cytoplasm)
GO:0032993 (protein-DNA complex)
GO Molecular Function GO:0000978 (RNA polymerase II core promoter proximal region sequence-specific DNA binding)
GO:0000979 (RNA polymerase II core promoter sequence-specific DNA binding)
GO:0001047 (core promoter binding)
GO:0001085 (RNA polymerase II transcription factor binding)
GO:0001102 (RNA polymerase II activating transcription factor binding)
GO:0001159 (core promoter proximal region DNA binding)
GO:0001228 (transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding)
GO:0002039 (p53 binding)
GO:0003677 (DNA binding)
GO:0003682 (chromatin binding)
GO:0003684 (damaged DNA binding)
GO:0003700 (transcription factor activity, sequence-specific DNA binding)
GO:0003712 (transcription cofactor activity)
GO:0003713 (transcription coactivator activity)
GO:0003823 (antigen binding)
GO:0004402 (histone acetyltransferase activity)
GO:0004468 (lysine N-acetyltransferase activity, acting on acetyl phosphate as donor)
GO:0005515 (protein binding)
GO:0008013 (beta-catenin binding)
GO:0008022 (protein C-terminus binding)
GO:0008134 (transcription factor binding)
GO:0008270 (zinc ion binding)
GO:0016407 (acetyltransferase activity)
GO:0016740 (transferase activity)
GO:0016746 (transferase activity, transferring acyl groups)
GO:0019901 (protein kinase binding)
GO:0031490 (chromatin DNA binding)
GO:0032403 (protein complex binding)
GO:0033613 (activating transcription factor binding)
GO:0034212 (peptide N-acetyltransferase activity)
GO:0035257 (nuclear hormone receptor binding)
GO:0035259 (glucocorticoid receptor binding)
GO:0042975 (peroxisome proliferator activated receptor binding)
GO:0043425 (bHLH transcription factor binding)
GO:0046332 (SMAD binding)
GO:0046872 (metal ion binding)
GO:0050681 (androgen receptor binding)
GO:0051019 (mitogen-activated protein kinase binding)
GO:0051059 (NF-kappaB binding)
GO:0097157 (pre-mRNA intronic binding)
GO:1990405 (protein antigen binding)
GO Biological Process GO:0000122 (negative regulation of transcription from RNA polymerase II promoter)
GO:0001666 (response to hypoxia)
GO:0001756 (somitogenesis)
GO:0001889 (liver development)
GO:0001934 (positive regulation of protein phosphorylation)
GO:0002223 (stimulatory C-type lectin receptor signaling pathway)
GO:0006283 (transcription-coupled nucleotide-excision repair)
GO:0006351 (transcription, DNA-templated)
GO:0006355 (regulation of transcription, DNA-templated)
GO:0006366 (transcription from RNA polymerase II promoter)
GO:0006473 (protein acetylation)
GO:0006475 (internal protein amino acid acetylation)
GO:0006915 (apoptotic process)
GO:0006977 (DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest)
GO:0006990 (positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response)
GO:0007049 (cell cycle)
GO:0007219 (Notch signaling pathway)
GO:0007399 (nervous system development)
GO:0007507 (heart development)
GO:0007519 (skeletal muscle tissue development)
GO:0007613 (memory)
GO:0007623 (circadian rhythm)
GO:0009749 (response to glucose)
GO:0009887 (organ morphogenesis)
GO:0010506 (regulation of autophagy)
GO:0010560 (positive regulation of glycoprotein biosynthetic process)
GO:0010628 (positive regulation of gene expression)
GO:0010942 (positive regulation of cell death)
GO:0014070 (response to organic cyclic compound)
GO:0014737 (positive regulation of muscle atrophy)
GO:0016032 (viral process)
GO:0016573 (histone acetylation)
GO:0018076 (N-terminal peptidyl-lysine acetylation)
GO:0018393 (internal peptidyl-lysine acetylation)
GO:0030183 (B cell differentiation)
GO:0030220 (platelet formation)
GO:0030307 (positive regulation of cell growth)
GO:0030324 (lung development)
GO:0031324 (negative regulation of cellular metabolic process)
GO:0031325 (positive regulation of cellular metabolic process)
GO:0032025 (response to cobalt ion)
GO:0032092 (positive regulation of protein binding)
GO:0032481 (positive regulation of type I interferon production)
GO:0032526 (response to retinoic acid)
GO:0032967 (positive regulation of collagen biosynthetic process)
GO:0033160 (positive regulation of protein import into nucleus, translocation)
GO:0034612 (response to tumor necrosis factor)
GO:0034644 (cellular response to UV)
GO:0035066 (positive regulation of histone acetylation)
GO:0035690 (cellular response to drug)
GO:0035855 (megakaryocyte development)
GO:0035984 (cellular response to trichostatin A)
GO:0042493 (response to drug)
GO:0042542 (response to hydrogen peroxide)
GO:0042771 (intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)
GO:0043154 (negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)
GO:0043388 (positive regulation of DNA binding)
GO:0043491 (protein kinase B signaling)
GO:0043627 (response to estrogen)
GO:0043923 (positive regulation by host of viral transcription)
GO:0043966 (histone H3 acetylation)
GO:0043967 (histone H4 acetylation)
GO:0043969 (histone H2B acetylation)
GO:0045444 (fat cell differentiation)
GO:0045471 (response to ethanol)
GO:0045727 (positive regulation of translation)
GO:0045773 (positive regulation of axon extension)
GO:0045793 (positive regulation of cell size)
GO:0045815 (positive regulation of gene expression, epigenetic)
GO:0045862 (positive regulation of proteolysis)
GO:0045893 (positive regulation of transcription, DNA-templated)
GO:0045944 (positive regulation of transcription from RNA polymerase II promoter)
GO:0048511 (rhythmic process)
GO:0048565 (digestive tract development)
GO:0050714 (positive regulation of protein secretion)
GO:0050821 (protein stabilization)
GO:0051091 (positive regulation of sequence-specific DNA binding transcription factor activity)
GO:0051592 (response to calcium ion)
GO:0051726 (regulation of cell cycle)
GO:0060177 (regulation of angiotensin metabolic process)
GO:0060298 (positive regulation of sarcomere organization)
GO:0060548 (negative regulation of cell death)
GO:0060765 (regulation of androgen receptor signaling pathway)
GO:0061418 (regulation of transcription from RNA polymerase II promoter in response to hypoxia)
GO:0065004 (protein-DNA complex assembly)
GO:0070301 (cellular response to hydrogen peroxide)
GO:0070542 (response to fatty acid)
GO:0071236 (cellular response to antibiotic)
GO:0071300 (cellular response to retinoic acid)
GO:0071320 (cellular response to cAMP)
GO:0071333 (cellular response to glucose stimulus)
GO:0071389 (cellular response to mineralocorticoid stimulus)
GO:0071407 (cellular response to organic cyclic compound)
GO:0071548 (response to dexamethasone)
GO:0071549 (cellular response to dexamethasone stimulus)
GO:0090043 (regulation of tubulin deacetylation)
GO:1900034 (regulation of cellular response to heat)
GO:1901796 (regulation of signal transduction by p53 class mediator)
GO:1901985 (positive regulation of protein acetylation)
GO:1904837 (beta-catenin-TCF complex assembly)
GO:1990090 (cellular response to nerve growth factor stimulus)
GO:2000629 (negative regulation of miRNA metabolic process)
Wikipedia EP300

Target Cross References - Protein

canSAR Q09472
CGD Rubinstein-Taybi syndrome
Human Protein Atlas ENSG00000100393
IntAct Q09472
Guide to Pharmacology 2735
Open Targets ENSG00000100393
PharmGKB PA27807
Reactome R-HSA-1234158 (Regulation of gene expression by Hypoxia-inducible Factor.)
R-HSA-1368082 (RORA activates gene expression.)
R-HSA-1368108 (BMAL1:CLOCK,NPAS2 activates circadian gene expression.)
R-HSA-156711 (Polo-like kinase mediated events.)
R-HSA-1912408 (Pre-NOTCH Transcription and Translation.)
R-HSA-1989781 (PPARA activates gene expression.)
R-HSA-201722 (Formation of the beta-catenin:TCF transactivating complex.)
R-HSA-2122947 (NOTCH1 Intracellular Domain Regulates Transcription.)
R-HSA-2197563 (NOTCH2 intracellular domain regulates transcription.)
R-HSA-2644606 (Constitutive Signaling by NOTCH1 PEST Domain Mutants.)
R-HSA-2894862 (Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants.)
R-HSA-3134973 (LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production.)
R-HSA-3214847 (HATs acetylate histones.)
R-HSA-3371568 (Attenuation phase.)
R-HSA-381340 (Transcriptional regulation of white adipocyte differentiation.)
R-HSA-400253 (Circadian Clock.)
R-HSA-5250924 (B-WICH complex positively regulates rRNA expression.)
R-HSA-5617472 (Activation of anterior HOX genes in hindbrain development during early embryogenesis.)
R-HSA-5621575 (CD209 (DC-SIGN) signaling.)
R-HSA-5689901 (Metalloprotease DUBs.)
R-HSA-6781823 (Formation of TC-NER Pre-Incision Complex.)
R-HSA-6781827 (Transcription-Coupled Nucleotide Excision Repair (TC-NER).)
R-HSA-6782135 (Dual incision in TC-NER.)
R-HSA-6782210 (Gap-filling DNA repair synthesis and ligation in TC-NER.)
R-HSA-6804114 (TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest.)
R-HSA-6804758 (Regulation of TP53 Activity through Acetylation.)
R-HSA-6804760 (Regulation of TP53 Activity through Methylation.)
R-HSA-6811555 (PI5P Regulates TP53 Acetylation.)
R-HSA-8866907 (Activation of the TFAP2 (AP-2) family of transcription factors.)
R-HSA-918233 (TRAF3-dependent IRF activation pathway.)
R-HSA-933541 (TRAF6 mediated IRF7 activation.)
R-HSA-983231 (Factors involved in megakaryocyte development and platelet production.)
UniProt B1AKC2 Q09472

Target Cross References - Domain

InterPro IPR000197 (Znf_TAZ.)
IPR000433 (Znf_ZZ.)
IPR001487 (Bromodomain.)
IPR003101 (KIX_dom.)
IPR009110 (Nuc_rcpt_coact.)
IPR010303 (RING_CBP-p300.)
IPR013178 (Histone_AcTrfase_Rtt109/CBP.)
IPR014744 (Nuc_rcpt_coact_CREBbp.)
IPR018359 (Bromodomain_CS.)
IPR031162 (CBP_P300_HAT.)
Pfam PF00439 (Bromodomain)
PF00569 (ZZ)
PF02135 (zf-TAZ)
PF02172 (KIX)
PF06001 (DUF902)
PF08214 (HAT_KAT11)
PF09030 (Creb_binding)

Target Cross References - Structure

PDBe 3BIY 3I3J 3IO2 3P57 3T92 4BHW 4PZR 4PZS 4PZT 5BT3 5LKT 5LKU 5LKX 5LKZ
CREDO 3BIY 3I3J 3IO2 3P57 3T92 4BHW 4PZR 4PZS 4PZT 5BT3 5LKT 5LKU 5LKX 5LKZ
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