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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL3776
Target Type SINGLE PROTEIN
Preferred Name Caspase-8
Synonyms Apoptotic cysteine protease | Apoptotic protease Mch-5 | CAP4 | CASP-8 | CASP8 | Caspase-8 | Caspase-8 subunit p10 | Caspase-8 subunit p18 | FADD-homologous ICE/ced-3-like protease | FADD-like ICE | FLICE | ICE-like apoptotic protease 5 | MACH | MCH5 | MORT1-associated ced-3 homolog
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > protease > cysteine protease > cysteine protease cd clan > cysteine protease c14 family

Target Components

Component Description Relationship Accession
Caspase-8 SINGLE PROTEIN Q14790

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000064012
Ensembl ENSG00000064012
GO Cellular Component GO:0005741 (mitochondrial outer membrane)
GO:0005813 (centrosome)
GO:0005829 (cytosol)
GO Molecular Function GO:0004197 (cysteine-type endopeptidase activity)
GO:0005515 (protein binding)
GO Biological Process GO:0006919 (activation of caspase activity)
GO:0006921 (cellular component disassembly involved in apoptosis)
GO:0008624 (induction of apoptosis by extracellular signals)
GO:0008629 (induction of apoptosis by intracellular signals)
GO:0008633 (activation of pro-apoptotic gene products)
GO:0034612 (response to tumor necrosis factor)
GO:0043123 (positive regulation of I-kappaB kinase/NF-kappaB cascade)
GO:0051603 (proteolysis involved in cellular protein catabolic process)
GO:0071260 (cellular response to mechanical stimulus)
Wikipedia Caspase_8

Target Cross References - Protein

canSAR Q14790
CGD Caspase 8 defiency
Human Protein Atlas ENSG00000064012
IntAct Q14790
PharmGKB PA26092
Reactome REACT_578 (Apoptosis.)
REACT_6900 (Signaling in Immune system.)
UniProt O14676 Q14790 Q14791 Q14792 Q14793 Q14794 Q14795 Q14796 Q15780 Q15806 Q53TT5 Q8TDI1 Q8TDI2 Q8TDI3 Q8TDI4 Q8TDI5 Q96T22 Q9C0K4 Q9UQ81

Target Cross References - Domain

InterPro IPR001309 (Pept_C14_ICE_p20.)
IPR001875 (DED.)
IPR002138 (Pept_C14_p10.)
IPR002398 (Pept_C14_p45.)
IPR011029 (DEATH-like.)
IPR011600 (Pept_C14_cat.)
IPR015917 (Pept_C14_p45_core.)
IPR016129 (Pept_C14_ICE_p20_AS.)
Pfam PF00656 (Peptidase_C14)
PF01335 (DED)

Target Cross References - Structure

PDBe 1F9E 1I4E 1QDU 1QTN 2C2Z 2FUN 3H11 3KJN 3KJQ
CREDO 1F9E 1I4E 1QDU 1QTN 2C2Z 2FUN 3H11 3KJN 3KJQ
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