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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL3772
Target Type SINGLE PROTEIN
Preferred Name Metabotropic glutamate receptor 1
Synonyms GPRC1A | GRM1 | MGLUR1 | Metabotropic glutamate receptor 1 | mGluR1
Organism Homo sapiens
Species Group No
Protein Target Classification
  • membrane receptor > family c g protein-coupled receptor > small molecule receptor (family c gpcr) > neurotransmitter receptor (family c gpcr) > metabotropic glutamate receptor

Target Components

Component Description Relationship Accession
Metabotropic glutamate receptor 1 SINGLE PROTEIN Q13255

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Expression Atlas ENSG00000152822
Ensembl ENSG00000152822
GO Cellular Component GO:0005887 (integral to plasma membrane)
GO Molecular Function GO:0004930 (G-protein coupled receptor activity)
GO:0008066 (glutamate receptor activity)
GO Biological Process GO:0007268 (synaptic transmission)
Wikipedia Metabotropic_glutamate_receptor_1

Target Cross References - Protein

CGD Spinocerebellar ataxia, autosomal recessive 13
Human Protein Atlas ENSG00000152822
Guide to Pharmacology 289 (mGlu1)
PharmGKB PA28990
Reactome REACT_14797 (Signaling by GPCR.)
UniProt B9EG79 Q13255 Q13256 Q14757 Q14758 Q5VTF7 Q5VTF8 Q9NU10 Q9UGS9 Q9UGT0

Target Cross References - Domain

InterPro IPR000162 (GPCR_3_mtglu_rcpt.)
IPR000337 (GPCR_3.)
IPR001256 (GPCR_3_mtglu_rcpt_1.)
IPR001828 (ANF_lig-bd_rcpt.)
IPR011500 (GPCR_3_9-Cys_dom.)
IPR017978 (GPCR_3_C.)
IPR017979 (GPCR_3_CS.)
IPR019588 (Metabotropic_Glu_rcpt_Homer-bd.)
Pfam PF00003 (7tm_3)
PF01094 (ANF_receptor)
PF07562 (NCD3G)
PF10606 (GluR_Homer-bdg)

Target Cross References - Structure

PDBe 3KS9
CREDO 3KS9
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