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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL3761
Target Type SINGLE PROTEIN
Preferred Name Beta-glucosidase
Synonyms Beta-glucocerebrosidase 2 | Beta-glucosidase 2 | GBA2 | Glucosylceramidase 2 | KIAA1605 | NLGase | Non-lysosomal glucosylceramidase
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
Non-lysosomal glucosylceramidase SINGLE PROTEIN Q9HCG7

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000070610
Ensembl ENSG00000070610
GO Cellular Component GO:0000139 (Golgi membrane)
GO:0005783 (endoplasmic reticulum)
GO:0005789 (endoplasmic reticulum membrane)
GO:0005790 (smooth endoplasmic reticulum)
GO:0005794 (Golgi apparatus)
GO:0005886 (plasma membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO Molecular Function GO:0003824 (catalytic activity)
GO:0004348 (glucosylceramidase activity)
GO:0004553 (hydrolase activity, hydrolyzing O-glycosyl compounds)
GO:0008422 (beta-glucosidase activity)
GO:0016787 (hydrolase activity)
GO:0016798 (hydrolase activity, acting on glycosyl bonds)
GO Biological Process GO:0006629 (lipid metabolic process)
GO:0006665 (sphingolipid metabolic process)
GO:0006680 (glucosylceramide catabolic process)
GO:0006687 (glycosphingolipid metabolic process)
GO:0008152 (metabolic process)
GO:0008206 (bile acid metabolic process)
GO:0016139 (glycoside catabolic process)
GO:0021954 (central nervous system neuron development)
Wikipedia GBA2

Target Cross References - Protein

canSAR Q9HCG7
CGD Cerebellar ataxia with spasticity, autosomal recessive
Human Protein Atlas ENSG00000070610
IntAct Q9HCG7
Open Targets ENSG00000070610
PharmGKB PA38773
Reactome R-HSA-1660662 (Glycosphingolipid metabolism.)
UniProt D3DRP2 Q5TCV6 Q96A51 Q96LY1 Q96SJ2 Q9H2L8 Q9HCG7

Target Cross References - Domain

InterPro IPR006775 (GH116_catalytic.)
IPR008928 (6-hairpin_glycosidase-like.)
IPR014551 (B_Glucosidase_GBA2-typ.)
IPR024462 (GH116_N.)
Pfam PF04685 (DUF608)
PF12215 (Glyco_hydr_116N)
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