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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL3760
Target Type SINGLE PROTEIN
Preferred Name Adenylate cyclase type II
Synonyms ADCY2 | ATP pyrophosphate-lyase 2 | Adenylate cyclase type 2 | Adenylate cyclase type II | Adenylyl cyclase 2 | KIAA1060
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
Adenylate cyclase type 2 SINGLE PROTEIN Q08462

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2097167 Adenylate cyclase PROTEIN FAMILY

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000078295
Ensembl ENSG00000078295
GO Cellular Component GO:0005887 (integral component of plasma membrane)
GO:0005622 (intracellular)
GO:0016020 (membrane)
GO:0030425 (dendrite)
GO:0005737 (cytoplasm)
GO:0005886 (plasma membrane)
GO:0045121 (membrane raft)
GO Molecular Function GO:0000287 (magnesium ion binding)
GO:0008179 (adenylate cyclase binding)
GO:0005524 (ATP binding)
GO:0004016 (adenylate cyclase activity)
GO:0030145 (manganese ion binding)
GO:0046982 (protein heterodimerization activity)
GO Biological Process GO:0007193 (adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway)
GO:0007165 (signal transduction)
GO:0044281 (small molecule metabolic process)
GO:0055085 (transmembrane transport)
GO:0007202 (activation of phospholipase C activity)
GO:0019933 (cAMP-mediated signaling)
GO:0048011 (neurotrophin TRK receptor signaling pathway)
GO:0006833 (water transport)
GO:0007188 (adenylate cyclase-modulating G-protein coupled receptor signaling pathway)
GO:0007189 (adenylate cyclase-activating G-protein coupled receptor signaling pathway)
GO:0007268 (synaptic transmission)
GO:0045087 (innate immune response)
GO:1904322 (cellular response to forskolin)
GO:0003091 (renal water homeostasis)
GO:0006112 (energy reserve metabolic process)
GO:0008543 (fibroblast growth factor receptor signaling pathway)
GO:0034199 (activation of protein kinase A activity)
GO:0006171 (cAMP biosynthetic process)
GO:0071377 (cellular response to glucagon stimulus)
GO:0007173 (epidermal growth factor receptor signaling pathway)
Wikipedia ADCY2

Target Cross References - Protein

canSAR Q08462
Human Protein Atlas ENSG00000078295
IntAct Q08462
Guide to Pharmacology 1279 (AC2)
PharmGKB PA24561
TIMBAL Adenylyl%20Cyclase
UniProt Q9UPU2 Q9UDB2 Q08462 Q2NKL8

Target Cross References - Domain

InterPro IPR032628 (AC_N.)
IPR001054 (A/G_cyclase.)
IPR009398 (Adcy_conserved_dom.)
IPR018297 (A/G_cyclase_CS.)
IPR029787 (Nucleotide_cyclase.)
IPR030672 (Adcy.)
Pfam PF16214 (AC_N)
PF06327 (DUF1053)
PF00211 (Guanylate_cyc)
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