ChEMBL logo

ChEMBL

spacer
ChEMBL Statistics
  Loading Statistics...
spacer

Target Report Card

Target Name and Classification

Target ID CHEMBL3760
Target Type SINGLE PROTEIN
Preferred Name Adenylate cyclase type II
Synonyms ADCY2 | ATP pyrophosphate-lyase 2 | Adenylate cyclase type 2 | Adenylate cyclase type II | Adenylyl cyclase 2 | KIAA1060
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
Adenylate cyclase type 2 SINGLE PROTEIN Q08462

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2097167 Adenylate cyclase PROTEIN FAMILY

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000078295
Ensembl ENSG00000078295
GO Cellular Component GO:0005737 (cytoplasm)
GO:0005886 (plasma membrane)
GO:0016021 (integral to membrane)
GO:0030425 (dendrite)
GO Molecular Function GO:0005524 (ATP binding)
GO:0046872 (metal ion binding)
GO Biological Process GO:0006112 (energy reserve metabolic process)
GO:0006833 (water transport)
GO:0007189 (activation of adenylate cyclase activity by G-protein signaling pathway)
GO:0007193 (inhibition of adenylate cyclase activity by G-protein signaling pathway)
GO:0007202 (activation of phospholipase C activity)
GO:0007268 (synaptic transmission)
GO:0034199 (activation of protein kinase A activity)
GO:0048011 (nerve growth factor receptor signaling pathway)
GO:0055085 (transmembrane transport)
GO:0071377 (cellular response to glucagon stimulus)
Wikipedia ADCY2

Target Cross References - Protein

canSAR Q08462
Human Protein Atlas ENSG00000078295
Guide to Pharmacology 1279 (AC2)
PharmGKB PA24561
Reactome REACT_11061 (Signalling by NGF.)
REACT_13685 (Synaptic Transmission.)
REACT_14797 (Signaling by GPCR.)
REACT_1505 (Integration of energy metabolism.)
REACT_15295 (Opioid Signalling.)
REACT_15518 (Transmembrane transport of small molecules.)
TIMBAL Adenylyl%20Cyclase
UniProt Q08462 Q2NKL8 Q9UDB2 Q9UPU2

Target Cross References - Domain

InterPro IPR001054 (A/G_cyclase.)
IPR009398 (Aden_cycl-like.)
IPR018297 (A/G_cyclase_CS.)
Pfam PF00211 (Guanylate_cyc)
PF06327 (DUF1053)
spacer
spacer