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Target Report Card

Target Name and Classification

Target ID CHEMBL3751
Preferred Name Estrogen-related receptor beta
Synonyms ERR beta-2 | ERR-beta | ERRB2 | ESRL2 | ESRRB | Estrogen receptor-like 2 | Estrogen-related receptor beta | NR3B2 | Nuclear receptor subfamily 3 group B member 2 | Steroid hormone receptor ERR2
Organism Homo sapiens
Species Group No
Protein Target Classification
  • transcription factor > nuclear receptor > nuclear hormone receptor subfamily 3 > nuclear hormone receptor subfamily 3 group b > nuclear hormone receptor subfamily 3 group b member 2

Target Components

Component Description Relationship Accession
Steroid hormone receptor ERR2 SINGLE PROTEIN O95718

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000119715
Ensembl ENSG00000119715
GO Cellular Component GO:0005634 (nucleus)
GO:0005654 (nucleoplasm)
GO Molecular Function GO:0000980 (RNA polymerase II distal enhancer sequence-specific DNA binding)
GO:0003677 (DNA binding)
GO:0003700 (transcription factor activity, sequence-specific DNA binding)
GO:0003707 (steroid hormone receptor activity)
GO:0003713 (transcription coactivator activity)
GO:0004879 (RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding)
GO:0005496 (steroid binding)
GO:0008134 (transcription factor binding)
GO:0008270 (zinc ion binding)
GO:0043565 (sequence-specific DNA binding)
GO:0046872 (metal ion binding)
GO Biological Process GO:0001892 (embryonic placenta development)
GO:0006351 (transcription, DNA-templated)
GO:0006355 (regulation of transcription, DNA-templated)
GO:0006367 (transcription initiation from RNA polymerase II promoter)
GO:0030522 (intracellular receptor signaling pathway)
GO:0043401 (steroid hormone mediated signaling pathway)
GO:0045944 (positive regulation of transcription from RNA polymerase II promoter)
Wikipedia Estrogen-related_receptor_beta

Target Cross References - Protein

CGD Deafness, autosomal recessive 35
Human Protein Atlas ENSG00000119715
IntAct O95718
Guide to Pharmacology 623
Open Targets ENSG00000119715
Pharos O95718 (Tchem)
Reactome R-HSA-383280 (Nuclear Receptor transcription pathway.)
UniProt A2VDJ2 B6ZGU4 O95718 Q5F0P7 Q5F0P8 Q9HCB4

Target Cross References - Domain

InterPro IPR000536 (Nucl_hrmn_rcpt_lig-bd.)
IPR001628 (Znf_hrmn_rcpt.)
IPR001723 (Nuclear_hrmn_rcpt.)
IPR013088 (Znf_NHR/GATA.)
IPR024178 (Oest_rcpt/oest-rel_rcp.)
IPR027289 (Oest-rel_rcp.)
Pfam PF00104 (Hormone_recep)
PF00105 (zf-C4)