ChEMBL logo

ChEMBL

spacer
ChEMBL Statistics
  Loading Statistics...
spacer

Target Report Card

Target Name and Classification

Target ID CHEMBL3735
Target Type SINGLE PROTEIN
Preferred Name Vascular cell adhesion protein 1
Synonyms CD_antigen=CD106 | INCAM-100 | V-CAM 1 | VCAM-1 | VCAM1 | Vascular cell adhesion protein 1
Organism Homo sapiens
Species Group No
Protein Target Classification
  • adhesion

Target Components

Component Description Relationship Accession
Vascular cell adhesion protein 1 SINGLE PROTEIN P19320

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000162692
Ensembl ENSG00000162692
GO Cellular Component GO:0002102 (podosome)
GO:0005615 (extracellular space)
GO:0005769 (early endosome)
GO:0005783 (endoplasmic reticulum)
GO:0005794 (Golgi apparatus)
GO:0005886 (plasma membrane)
GO:0005902 (microvillus)
GO:0009897 (external side of plasma membrane)
GO:0009986 (cell surface)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0030175 (filopodium)
GO:0042383 (sarcolemma)
GO:0045177 (apical part of cell)
GO:0070062 (extracellular exosome)
GO:0071065 (alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)
GO Molecular Function GO:0005178 (integrin binding)
GO:0005515 (protein binding)
GO:0008131 (primary amine oxidase activity)
GO:0050839 (cell adhesion molecule binding)
GO Biological Process GO:0001666 (response to hypoxia)
GO:0002526 (acute inflammatory response)
GO:0002544 (chronic inflammatory response)
GO:0007155 (cell adhesion)
GO:0007157 (heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)
GO:0007159 (leukocyte cell-cell adhesion)
GO:0007160 (cell-matrix adhesion)
GO:0007568 (aging)
GO:0007584 (response to nutrient)
GO:0009308 (amine metabolic process)
GO:0010043 (response to zinc ion)
GO:0010212 (response to ionizing radiation)
GO:0016032 (viral process)
GO:0019221 (cytokine-mediated signaling pathway)
GO:0022614 (membrane to membrane docking)
GO:0030183 (B cell differentiation)
GO:0030198 (extracellular matrix organization)
GO:0032496 (response to lipopolysaccharide)
GO:0035094 (response to nicotine)
GO:0035584 (calcium-mediated signaling using intracellular calcium source)
GO:0035924 (cellular response to vascular endothelial growth factor stimulus)
GO:0042102 (positive regulation of T cell proliferation)
GO:0045471 (response to ethanol)
GO:0050776 (regulation of immune response)
GO:0050901 (leukocyte tethering or rolling)
GO:0055114 (oxidation-reduction process)
GO:0060326 (cell chemotaxis)
GO:0060333 (interferon-gamma-mediated signaling pathway)
GO:0071356 (cellular response to tumor necrosis factor)
GO:0098609 (cell-cell adhesion)
Wikipedia VCAM-1

Target Cross References - Protein

canSAR P19320
Human Protein Atlas ENSG00000162692
IntAct P19320
Open Targets ENSG00000162692
PharmGKB PA37286
Reactome R-HSA-198933 (Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.)
R-HSA-216083 (Integrin cell surface interactions.)
R-HSA-6785807 (Interleukin-4 and 13 signaling.)
R-HSA-877300 (Interferon gamma signaling.)
UniProt A8K6R7 B4DKS4 E9PDD1 P19320 Q6NUP8

Target Cross References - Domain

InterPro IPR003598 (Ig_sub2.)
IPR003599 (Ig_sub.)
IPR003987 (ICAM_VCAM_N.)
IPR003989 (VCAM-1.)
IPR007110 (Ig-like_dom.)
IPR008424 (Ig_C2-set.)
IPR013098 (Ig_I-set.)
IPR013106 (Ig_V-set.)
IPR013151 (Immunoglobulin.)
IPR013783 (Ig-like_fold.)
IPR036179 (Ig-like_dom_sf.)
Pfam PF00047 (ig)
PF05790 (C2-set)
PF07679 (I-set)

Target Cross References - Structure

PDBe 1IJ9 1VCA 1VSC
CREDO 1IJ9 1VCA 1VSC
spacer
spacer