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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL3731
Preferred Name Amphiregulin
Synonyms AREG | Amphiregulin | CRDGF | Colorectum cell-derived growth factor | SDGF | Synonyms=AREGB
Organism Homo sapiens
Species Group No
Protein Target Classification
  • secreted protein

Target Components

Component Description Relationship Accession
Amphiregulin SINGLE PROTEIN P15514

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000109321
Ensembl ENSG00000109321
GO Cellular Component GO:0000139 (Golgi membrane)
GO:0005615 (extracellular space)
GO:0005622 (intracellular)
GO:0005634 (nucleus)
GO:0005737 (cytoplasm)
GO:0005789 (endoplasmic reticulum membrane)
GO:0009986 (cell surface)
GO:0012507 (ER to Golgi transport vesicle membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0033116 (endoplasmic reticulum-Golgi intermediate compartment membrane)
GO Molecular Function GO:0005125 (cytokine activity)
GO:0005154 (epidermal growth factor receptor binding)
GO:0005515 (protein binding)
GO:0008083 (growth factor activity)
GO Biological Process GO:0006888 (ER to Golgi vesicle-mediated transport)
GO:0007173 (epidermal growth factor receptor signaling pathway)
GO:0007186 (G-protein coupled receptor signaling pathway)
GO:0007267 (cell-cell signaling)
GO:0008283 (cell proliferation)
GO:0008284 (positive regulation of cell proliferation)
GO:0010469 (regulation of receptor activity)
GO:0014009 (glial cell proliferation)
GO:0014070 (response to organic cyclic compound)
GO:0031175 (neuron projection development)
GO:0032355 (response to estradiol)
GO:0042327 (positive regulation of phosphorylation)
GO:0042542 (response to hydrogen peroxide)
GO:0043434 (response to peptide hormone)
GO:0045668 (negative regulation of osteoblast differentiation)
GO:0048208 (COPII vesicle coating)
GO:0050731 (positive regulation of peptidyl-tyrosine phosphorylation)
GO:0051384 (response to glucocorticoid)
GO:0051591 (response to cAMP)
GO:0060598 (dichotomous subdivision of terminal units involved in mammary gland duct morphogenesis)
GO:0060744 (mammary gland branching involved in thelarche)
GO:0060749 (mammary gland alveolus development)
GO:0060750 (epithelial cell proliferation involved in mammary gland duct elongation)
Wikipedia Amphiregulin

Target Cross References - Protein

canSAR P15514
Human Protein Atlas ENSG00000109321
IntAct P15514
Open Targets ENSG00000109321
PharmGKB PA162376851
Reactome R-HSA-204005 (COPII (Coat Protein 2) Mediated Vesicle Transport.)
R-HSA-5694530 (Cargo concentration in the ER.)
UniProt P15514 Q5U026

Target Cross References - Domain

InterPro IPR000742 (EGF-like_dom.)
IPR013032 (EGF-like_CS.)
IPR015497 (EGF_rcpt_ligand.)