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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL3731
Target Type SINGLE PROTEIN
Preferred Name Amphiregulin
Synonyms AR | AREGB | Amphiregulin | CRDGF | Colorectum cell-derived growth factor | SDGF | and
Organism Homo sapiens
Species Group No
Protein Target Classification
  • secreted protein

Target Components

Component Description Relationship Accession
Amphiregulin SINGLE PROTEIN P15514

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000109321 ENSG00000205595
Ensembl ENSG00000109321 ENSG00000205595
GO Cellular Component GO:0005615 (extracellular space)
GO:0009986 (cell surface)
GO:0016021 (integral to membrane)
GO Molecular Function GO:0005125 (cytokine activity)
GO:0008083 (growth factor activity)
GO Biological Process GO:0007173 (epidermal growth factor receptor signaling pathway)
GO:0007186 (G-protein coupled receptor protein signaling pathway)
GO:0007267 (cell-cell signaling)
GO:0008283 (cell proliferation)
GO:0045740 (positive regulation of DNA replication)
Wikipedia Amphiregulin

Target Cross References - Protein

canSAR P15514
Human Protein Atlas ENSG00000109321 ENSG00000205595
IntAct P15514
PharmGKB PA162376851
UniProt P15514

Target Cross References - Domain

InterPro IPR000742 (EGF_3.)
IPR006210 (EGF-like.)
IPR013032 (EGF-like_reg_CS.)
IPR015497 (EGF_rcpt_ligand.)
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