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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL3729
Target Type SINGLE PROTEIN
Preferred Name Carbonic anhydrase IV
Synonyms CA-IV | CA4 | Carbonate dehydratase IV | Carbonic anhydrase 4 | Carbonic anhydrase IV
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > lyase

Target Components

Component Description Relationship Accession
Carbonic anhydrase 4 SINGLE PROTEIN P22748

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2095180 Carbonic anhydrase PROTEIN FAMILY

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL17 DICHLORPHENAMIDE Carbonic anhydrase IV inhibitor 4 PubMed
CHEMBL19 METHAZOLAMIDE Carbonic anhydrase IV inhibitor 4 DailyMed PubMed
CHEMBL20 ACETAZOLAMIDE Carbonic anhydrase IV inhibitor 4 PubMed
CHEMBL220492 TOPIRAMATE Carbonic anhydrase IV inhibitor 4 DailyMed PubMed
CHEMBL1200814 ACETAZOLAMIDE SODIUM Carbonic anhydrase IV inhibitor 4 PubMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000167434
Ensembl ENSG00000167434
GO Cellular Component GO:0005791 (rough endoplasmic reticulum)
GO:0005793 (endoplasmic reticulum-Golgi intermediate compartment)
GO:0005794 (Golgi apparatus)
GO:0005802 (trans-Golgi network)
GO:0005886 (plasma membrane)
GO:0009986 (cell surface)
GO:0016020 (membrane)
GO:0016323 (basolateral plasma membrane)
GO:0016324 (apical plasma membrane)
GO:0030658 (transport vesicle membrane)
GO:0030667 (secretory granule membrane)
GO:0031225 (anchored component of membrane)
GO:0031362 (anchored component of external side of plasma membrane)
GO:0031526 (brush border membrane)
GO:0046658 (anchored component of plasma membrane)
GO:0048471 (perinuclear region of cytoplasm)
GO:0070062 (extracellular exosome)
GO Molecular Function GO:0004089 (carbonate dehydratase activity)
GO:0005515 (protein binding)
GO:0008270 (zinc ion binding)
GO:0016829 (lyase activity)
GO:0046872 (metal ion binding)
GO Biological Process GO:0006730 (one-carbon metabolic process)
GO:0015701 (bicarbonate transport)
Wikipedia Carbonic_anhydrase_4

Target Cross References - Protein

canSAR P22748
CGD Retinitis pigmentosa 17
Human Protein Atlas ENSG00000167434
IntAct P22748
Guide to Pharmacology 2599
Open Targets ENSG00000167434
PharmGKB PA25991
Reactome R-HSA-1237044 (Erythrocytes take up carbon dioxide and release oxygen.)
R-HSA-1247673 (Erythrocytes take up oxygen and release carbon dioxide.)
R-HSA-1475029 (Reversible hydration of carbon dioxide.)
UniProt B4DQA4 P22748 Q6FHI7

Target Cross References - Domain

InterPro IPR001148 (Carbonic_anhydrase_a.)
IPR018338 (Carbonic_anhydrase_a-class_CS.)
IPR018343 (Carbonic_anhydrase_CA4.)
IPR023561 (Carbonic_anhydrase_a-class.)
Pfam PF00194 (Carb_anhydrase)

Target Cross References - Structure

PDBe 1ZNC 3F7B 3F7U 3FW3
CREDO 1ZNC 3F7B 3F7U 3FW3
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