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Target Report Card

Target Name and Classification

Target ID CHEMBL3717
Target Type SINGLE PROTEIN
Preferred Name Hepatocyte growth factor receptor
Synonyms HGF receptor | HGF/SF receptor | Hepatocyte growth factor receptor | MET | Proto-oncogene c-Met | SF receptor | Scatter factor receptor | Tyrosine-protein kinase Met
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > tk protein kinase group > tyrosine protein kinase met family

Target Components

Component Description Relationship Accession
Hepatocyte growth factor receptor SINGLE PROTEIN P08581

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL601719 CRIZOTINIB Hepatocyte growth factor receptor inhibitor 4 FDA
CHEMBL2103868 CABOZANTINIB S-MALATE Hepatocyte growth factor receptor inhibitor 4 DailyMed PubMed PubMed
CHEMBL2103882 TIVANTINIB Hepatocyte growth factor receptor inhibitor 3 PubMed PubMed
CHEMBL254760 MGCD-265 Hepatocyte growth factor receptor inhibitor 2 Other
CHEMBL460702 BMS-777607 Hepatocyte growth factor receptor inhibitor 2 PubMed PubMed
CHEMBL1230609 FORETINIB Hepatocyte growth factor receptor inhibitor 2
CHEMBL1822792 MK-2461 Hepatocyte growth factor receptor inhibitor 2 PubMed
CHEMBL2103851 AMUVATINIB Hepatocyte growth factor receptor inhibitor 2
CHEMBL3039525 GOLVATINIB Hepatocyte growth factor receptor inhibitor 2 PubMed
CHEMBL3188267 CAPMATINIB Hepatocyte growth factor receptor inhibitor 2 Other Other Other
CHEMBL3402762 Tepotinib Hepatocyte growth factor receptor inhibitor 2
CHEMBL3545212 AMG-337 Hepatocyte growth factor receptor inhibitor 2 Other PubMed
CHEMBL3545336 Savolitinib Hepatocyte growth factor receptor inhibitor 2 PubMed PubMed
CHEMBL496102 AMG-208 Hepatocyte growth factor receptor inhibitor 1 Other PubMed
CHEMBL1236107 SGX-523 Hepatocyte growth factor receptor inhibitor 1 PubMed PubMed
CHEMBL2001019 PF-04217903 Hepatocyte growth factor receptor inhibitor 1 PubMed
CHEMBL2133806 JNJ-38877605 Hepatocyte growth factor receptor inhibitor 1 Other PubMed
CHEMBL2323775 MK-8033 Hepatocyte growth factor receptor inhibitor 1 PubMed
CHEMBL3545050 BMS-817378 Hepatocyte growth factor receptor inhibitor 1 DOI
CHEMBL3545053 EMD-1204831 Hepatocyte growth factor receptor inhibitor 1 PubMed PubMed
CHEMBL3545119 BMS-794833 Hepatocyte growth factor receptor inhibitor 1 Other
CHEMBL3545144 TAS-115 Hepatocyte growth factor receptor inhibitor 1 Other PubMed
CHEMBL3545236 BPI-9016 Hepatocyte growth factor receptor inhibitor 1
CHEMBL3545299 BMS-698769 Hepatocyte growth factor receptor inhibitor 1 Other
CHEMBL3545307 MERESTINIB Hepatocyte growth factor receptor inhibitor 1 Other PubMed
CHEMBL3545325 SAR-125844 Hepatocyte growth factor receptor inhibitor 1 PubMed
CHEMBL3545359 ARRY-300 Hepatocyte growth factor receptor inhibitor 1 PubMed
CHEMBL3545365 ALTIRATINIB Hepatocyte growth factor receptor inhibitor 1 Other PubMed
CHEMBL3545419 ABT-700 Hepatocyte growth factor receptor inhibitor 1 Other Other
More...

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000105976
Ensembl ENSG00000105976
GO Cellular Component GO:0005887 (integral to plasma membrane)
GO:0009925 (basal plasma membrane)
GO Molecular Function GO:0005008 (hepatocyte growth factor receptor activity)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO Biological Process GO:0006468 (protein phosphorylation)
GO:0007411 (axon guidance)
GO:0008283 (cell proliferation)
Wikipedia C-Met

Target Cross References - Protein

canSAR P08581
CGD Renal cell carcinoma, papillary
Human Protein Atlas ENSG00000105976
IntAct P08581
Guide to Pharmacology 1815 (MET proto-oncogene, receptor tyrosine kinase)
PharmGKB PA30763
Reactome REACT_18266 (Axon guidance.)
UniProt O60366 P08581 Q12875 Q9UDX7 Q9UPL8

Target Cross References - Domain

InterPro IPR000719 (Prot_kinase_cat_dom.)
IPR001245 (Ser-Thr/Tyr-Pkinase.)
IPR001627 (Semaphorin/CD100_Ag.)
IPR002165 (Plexin_repeat.)
IPR002909 (IPT_TIG_rcpt.)
IPR003659 (Plexin-like.)
IPR008266 (Tyr_prot_kinase_AS.)
IPR011009 (Kinase-like_dom.)
IPR013783 (Ig-like_fold.)
IPR014756 (Ig_E-set.)
IPR015943 (WD40/YVTN_repeat-like_dom.)
IPR016201 (Plexin-like_fold.)
IPR016244 (Tyr_prot_kinase_HGF/MSP_rcpt.)
IPR017441 (Protein_kinase_ATP_BS.)
IPR020635 (Tyr_Pkinase_cat_dom.)
Pfam PF01403 (Sema)
PF01437 (PSI)
PF01833 (TIG)
PF07714 (Pkinase_Tyr)

Target Cross References - Structure

PDBe 1FYR 1R0P 1R1W 1SHY 2G15 2RFN 2RFS 2UZX 2UZY 2WD1 2WGJ 2WKM 3A4P 3BUX 3C1X 3CCN 3CD8 3CE3 3CTH 3CTJ 3DKC 3DKF 3DKG 3EFJ More...
CREDO 1FYR 1R0P 1R1W 1SHY 2G15 2RFN 2RFS 2UZX 2UZY 2WD1 2WGJ 2WKM 3A4P 3BUX 3C1X 3CCN 3CD8 3CE3 3CTH 3CTJ 3DKC 3DKF 3DKG 3EFJ More...
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