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Target Report Card

Target Name and Classification

Target ID CHEMBL3716
Preferred Name Integrin alpha-6
Synonyms Alpha6p | CD49 antigen-like family member F | CD_antigen=CD49f | ITGA6 | Integrin alpha-6 heavy chain | Integrin alpha-6 light chain | Integrin alpha-6 | Processed integrin alpha-6 | VLA-6
Organism Homo sapiens
Species Group No
Protein Target Classification
  • membrane receptor

Target Components

Component Description Relationship Accession
Integrin alpha-6 SINGLE PROTEIN P23229

Target Relations

ChEMBL ID Pref Name Target Type

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000091409
Ensembl ENSG00000091409
GO Cellular Component GO:0005604 (basement membrane)
GO:0005886 (plasma membrane)
GO:0005913 (cell-cell adherens junction)
GO:0005925 (focal adhesion)
GO:0008305 (integrin complex)
GO:0009897 (external side of plasma membrane)
GO:0009925 (basal plasma membrane)
GO:0009986 (cell surface)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0016323 (basolateral plasma membrane)
GO:0030056 (hemidesmosome)
GO:0030175 (filopodium)
GO:0034676 (integrin alpha6-beta4 complex)
GO:0045178 (basal part of cell)
GO Molecular Function GO:0005178 (integrin binding)
GO:0005515 (protein binding)
GO:0031994 (insulin-like growth factor I binding)
GO:0038132 (neuregulin binding)
GO:0043236 (laminin binding)
GO:0044877 (macromolecular complex binding)
GO:0045296 (cadherin binding)
GO:0046872 (metal ion binding)
GO Biological Process GO:0007044 (cell-substrate junction assembly)
GO:0007155 (cell adhesion)
GO:0007160 (cell-matrix adhesion)
GO:0007229 (integrin-mediated signaling pathway)
GO:0010668 (ectodermal cell differentiation)
GO:0010811 (positive regulation of cell-substrate adhesion)
GO:0022409 (positive regulation of cell-cell adhesion)
GO:0030198 (extracellular matrix organization)
GO:0030335 (positive regulation of cell migration)
GO:0031581 (hemidesmosome assembly)
GO:0031589 (cell-substrate adhesion)
GO:0031668 (cellular response to extracellular stimulus)
GO:0033627 (cell adhesion mediated by integrin)
GO:0035878 (nail development)
GO:0042327 (positive regulation of phosphorylation)
GO:0042475 (odontogenesis of dentin-containing tooth)
GO:0043065 (positive regulation of apoptotic process)
GO:0043547 (positive regulation of GTPase activity)
GO:0043588 (skin development)
GO:0045944 (positive regulation of transcription from RNA polymerase II promoter)
GO:0046847 (filopodium assembly)
GO:0048565 (digestive tract development)
GO:0050873 (brown fat cell differentiation)
GO:0050900 (leukocyte migration)
GO:0071407 (cellular response to organic cyclic compound)
GO:0072001 (renal system development)
GO:0097186 (amelogenesis)
GO:0098609 (cell-cell adhesion)
GO:2001237 (negative regulation of extrinsic apoptotic signaling pathway)
Wikipedia ITGA6

Target Cross References - Protein

canSAR P23229
CGD Epidermolysis bullosa, junctional, with pyloric stenosis
Human Protein Atlas ENSG00000091409
IntAct P23229
Open Targets ENSG00000091409
PharmGKB PA29942
Reactome R-HSA-2022090 (Assembly of collagen fibrils and other multimeric structures.)
R-HSA-210991 (Basigin interactions.)
R-HSA-216083 (Integrin cell surface interactions.)
R-HSA-3000157 (Laminin interactions.)
R-HSA-3000170 (Syndecan interactions.)
R-HSA-446107 (Type I hemidesmosome assembly.)
TIMBAL Integrins
UniProt B2RMU9 B4DG69 B4DKB8 C4AM96 G5E9H1 P23229 Q08443 Q0MRC7 Q14646 Q16508 Q53RX7 Q59HB7 Q86VL6 Q9UCT1 Q9UN03

Target Cross References - Domain

InterPro IPR000413 (Integrin_alpha.)
IPR013517 (FG-GAP.)
IPR013519 (Int_alpha_beta-p.)
IPR013649 (Integrin_alpha-2.)
IPR018184 (Integrin_alpha_C_CS.)
IPR028994 (Integrin_alpha_N.)
IPR032695 (Integrin_dom_sf.)
Pfam PF01839 (FG-GAP)
PF08441 (Integrin_alpha2)