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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL3708
Preferred Name Presenilin 2
Synonyms AD3LP | AD4 | AD5 | E5-1 | PS-2 | PS2 | PSEN2 | PSNL2 | Presenilin-2 CTF subunit | Presenilin-2 NTF subunit | Presenilin-2 | STM-2 | STM2
Organism Homo sapiens
Species Group No
Protein Target Classification
  • ion channel > other ion channel > miscellaneous ion channel > presenilin er ca2+ leak channel family

Target Components

Component Description Relationship Accession
Presenilin-2 SINGLE PROTEIN P49810

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2094135 Gamma-secretase PROTEIN COMPLEX

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000143801
Ensembl ENSG00000143801
GO Cellular Component GO:0000139 (Golgi membrane)
GO:0000776 (kinetochore)
GO:0005637 (nuclear inner membrane)
GO:0005783 (endoplasmic reticulum)
GO:0005789 (endoplasmic reticulum membrane)
GO:0005794 (Golgi apparatus)
GO:0005813 (centrosome)
GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0005938 (cell cortex)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0016324 (apical plasma membrane)
GO:0030018 (Z disc)
GO:0043025 (neuronal cell body)
GO:0043234 (protein complex)
GO:0048471 (perinuclear region of cytoplasm)
GO Molecular Function GO:0004175 (endopeptidase activity)
GO:0004190 (aspartic-type endopeptidase activity)
GO:0005515 (protein binding)
GO:0008233 (peptidase activity)
GO:0016787 (hydrolase activity)
GO Biological Process GO:0001666 (response to hypoxia)
GO:0006508 (proteolysis)
GO:0006509 (membrane protein ectodomain proteolysis)
GO:0006816 (calcium ion transport)
GO:0007219 (Notch signaling pathway)
GO:0007220 (Notch receptor processing)
GO:0016485 (protein processing)
GO:0031293 (membrane protein intracellular domain proteolysis)
GO:0035556 (intracellular signal transduction)
GO:0042987 (amyloid precursor protein catabolic process)
GO:0043065 (positive regulation of apoptotic process)
GO:0043066 (negative regulation of apoptotic process)
GO:0043085 (positive regulation of catalytic activity)
GO:0048013 (ephrin receptor signaling pathway)
GO:0050435 (beta-amyloid metabolic process)
Wikipedia PSEN2

Target Cross References - Protein

canSAR P49810
CGD Cardiomyopathy, dilated, 1V; Peripartum/pregnancy-associated cardiomyopathy
Human Protein Atlas ENSG00000143801
IntAct P49810
Open Targets ENSG00000143801
PharmGKB PA33856
Reactome R-HSA-1251985 (Nuclear signaling by ERBB4.)
R-HSA-193692 (Regulated proteolysis of p75NTR.)
R-HSA-1980148 (Signaling by NOTCH3.)
R-HSA-1980150 (Signaling by NOTCH4.)
R-HSA-205043 (NRIF signals cell death from the nucleus.)
R-HSA-2122948 (Activated NOTCH1 Transmits Signal to the Nucleus.)
R-HSA-2644606 (Constitutive Signaling by NOTCH1 PEST Domain Mutants.)
R-HSA-2894862 (Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants.)
R-HSA-2979096 (NOTCH2 Activation and Transmission of Signal to the Nucleus.)
R-HSA-3928665 (EPH-ephrin mediated repulsion of cells.)
UniProt A8K8D4 B1AP21 P49810 Q96P32

Target Cross References - Domain

InterPro IPR001108 (Peptidase_A22A.)
IPR001493 (Pept_A22A_PS2.)
IPR006639 (Preselin/SPP.)
Pfam PF01080 (Presenilin)