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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL3692
Target Type SINGLE PROTEIN
Preferred Name Receptor-type tyrosine-protein phosphatase eta
Synonyms CD_antigen=CD148 | DEP-1 | DEP1 | Density-enhanced phosphatase 1 | HPTP eta | PTPRJ | Protein-tyrosine phosphatase eta | Protein-tyrosine phosphatase receptor type J | R-PTP-J | R-PTP-eta | Receptor-type tyrosine-protein phosphatase eta
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > phosphatase > protein phosphatase > tyrosine protein phosphatase > receptor tyrosine-protein phosphatase

Target Components

Component Description Relationship Accession
Receptor-type tyrosine-protein phosphatase eta SINGLE PROTEIN Q12913

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000149177
Ensembl ENSG00000149177
GO Cellular Component GO:0001772 (immunological synapse)
GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0005911 (cell-cell junction)
GO:0009986 (cell surface)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0030054 (cell junction)
GO:0032587 (ruffle membrane)
GO:0042995 (cell projection)
GO:0070062 (extracellular exosome)
GO Molecular Function GO:0004721 (phosphoprotein phosphatase activity)
GO:0004725 (protein tyrosine phosphatase activity)
GO:0005161 (platelet-derived growth factor receptor binding)
GO:0005515 (protein binding)
GO:0008013 (beta-catenin binding)
GO:0016787 (hydrolase activity)
GO:0016791 (phosphatase activity)
GO:0019901 (protein kinase binding)
GO:0045295 (gamma-catenin binding)
GO:0051019 (mitogen-activated protein kinase binding)
GO:0070097 (delta-catenin binding)
GO Biological Process GO:0006470 (protein dephosphorylation)
GO:0008285 (negative regulation of cell proliferation)
GO:0010642 (negative regulation of platelet-derived growth factor receptor signaling pathway)
GO:0016311 (dephosphorylation)
GO:0030155 (regulation of cell adhesion)
GO:0030308 (negative regulation of cell growth)
GO:0030336 (negative regulation of cell migration)
GO:0035335 (peptidyl-tyrosine dephosphorylation)
GO:0042059 (negative regulation of epidermal growth factor receptor signaling pathway)
GO:0043116 (negative regulation of vascular permeability)
GO:0043407 (negative regulation of MAP kinase activity)
GO:0045785 (positive regulation of cell adhesion)
GO:0048008 (platelet-derived growth factor receptor signaling pathway)
GO:0050852 (T cell receptor signaling pathway)
GO:0050860 (negative regulation of T cell receptor signaling pathway)
GO:0050918 (positive chemotaxis)
GO:0051894 (positive regulation of focal adhesion assembly)
GO:0051897 (positive regulation of protein kinase B signaling)
GO:0051898 (negative regulation of protein kinase B signaling)
GO:0060242 (contact inhibition)
Wikipedia PTPRJ

Target Cross References - Protein

canSAR Q12913
Human Protein Atlas ENSG00000149177
IntAct Q12913
Open Targets ENSG00000149177
PharmGKB PA34018
Reactome R-HSA-202427 (Phosphorylation of CD3 and TCR zeta chains.)
R-HSA-6798695 (Neutrophil degranulation.)
R-HSA-6807004 (Negative regulation of MET activity.)
UniProt Q12913 Q15255 Q6P4H4 Q8NHM2 Q9UDA9

Target Cross References - Domain

InterPro IPR000242 (PTPase_domain.)
IPR000387 (TYR_PHOSPHATASE_dom.)
IPR003595 (Tyr_Pase_cat.)
IPR003961 (FN3_dom.)
IPR013783 (Ig-like_fold.)
IPR016130 (Tyr_Pase_AS.)
IPR029021 (Prot-tyrosine_phosphatase-like.)
Pfam PF00041 (fn3)
PF00102 (Y_phosphatase)

Target Cross References - Structure

PDBe 2CFV 2NZ6
CREDO 2CFV 2NZ6
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