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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL3684
Preferred Name Glutamate receptor ionotropic kainate 3
Synonyms EAA5 | Excitatory amino acid receptor 5 | GLUR7 | GRIK3 | GluK3 | GluR-7 | GluR7 | Glutamate receptor 7 | Glutamate receptor ionotropic, kainate 3
Organism Homo sapiens
Species Group No
Protein Target Classification
  • ion channel > ligand-gated ion channel > ionotropic glutamate receptor > kainate receptor

Target Components

Component Description Relationship Accession
Glutamate receptor ionotropic, kainate 3 SINGLE PROTEIN Q13003

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2109241 Glutamate receptor ionotropic kainate PROTEIN COMPLEX GROUP

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000163873
Ensembl ENSG00000163873
GO Cellular Component GO:0005887 (integral to plasma membrane)
GO:0030054 (cell junction)
GO:0032839 (dendrite cytoplasm)
GO:0043195 (terminal button)
GO:0043204 (perikaryon)
GO:0045211 (postsynaptic membrane)
GO Molecular Function GO:0001640 (adenylate cyclase inhibiting metabotropic glutamate receptor activity)
GO:0001664 (G-protein-coupled receptor binding)
GO:0005234 (extracellular-glutamate-gated ion channel activity)
GO:0015277 (kainate selective glutamate receptor activity)
GO Biological Process GO:0007268 (synaptic transmission)
GO:0042391 (regulation of membrane potential)
GO:0051967 (negative regulation of synaptic transmission, glutamatergic)
Wikipedia GRIK3

Target Cross References - Protein

canSAR Q13003
Human Protein Atlas ENSG00000163873
Guide to Pharmacology 452 (GluK3)
PharmGKB PA28975
Reactome REACT_13685 (Synaptic Transmission.)
UniProt B1AMS6 Q13003 Q13004 Q16136

Target Cross References - Domain

InterPro IPR001320 (Iontro_glu_rcpt.)
IPR001508 (NMDA_rcpt.)
IPR001828 (ANF_lig-bd_rcpt.)
IPR019594 (Glu_rcpt_Glu/Gly-bd.)
Pfam PF00060 (Lig_chan)
PF01094 (ANF_receptor)
PF10613 (Lig_chan-Glu_bd)