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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL3682
Target Type SINGLE PROTEIN
Preferred Name Integrin alpha-1
Synonyms CD49 antigen-like family member A | CD_antigen=CD49a | ITGA1 | Integrin alpha-1 | Laminin and collagen receptor | VLA-1
Organism Homo sapiens
Species Group No
Protein Target Classification
  • membrane receptor

Target Components

Component Description Relationship Accession
Integrin alpha-1 SINGLE PROTEIN P56199

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL3137278 Integrin alpha1/beta1 complex PROTEIN COMPLEX

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000213949
Ensembl ENSG00000213949
GO Cellular Component GO:0001669 (acrosomal vesicle)
GO:0005886 (plasma membrane)
GO:0005925 (focal adhesion)
GO:0008305 (integrin complex)
GO:0009897 (external side of plasma membrane)
GO:0009986 (cell surface)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0034665 (integrin alpha1-beta1 complex)
GO:0043005 (neuron projection)
GO:0043204 (perikaryon)
GO:0045121 (membrane raft)
GO:0045178 (basal part of cell)
GO:0070062 (extracellular exosome)
GO Molecular Function GO:0005102 (receptor binding)
GO:0005515 (protein binding)
GO:0005518 (collagen binding)
GO:0019903 (protein phosphatase binding)
GO:0046872 (metal ion binding)
GO:0098639 (collagen binding involved in cell-matrix adhesion)
GO Biological Process GO:0000187 (activation of MAPK activity)
GO:0006936 (muscle contraction)
GO:0007155 (cell adhesion)
GO:0007160 (cell-matrix adhesion)
GO:0007229 (integrin-mediated signaling pathway)
GO:0008285 (negative regulation of cell proliferation)
GO:0030198 (extracellular matrix organization)
GO:0030593 (neutrophil chemotaxis)
GO:0032516 (positive regulation of phosphoprotein phosphatase activity)
GO:0042059 (negative regulation of epidermal growth factor receptor signaling pathway)
GO:0042311 (vasodilation)
GO:0043525 (positive regulation of neuron apoptotic process)
GO:0045123 (cellular extravasation)
GO:0048812 (neuron projection morphogenesis)
GO:0060326 (cell chemotaxis)
Wikipedia CD49a

Target Cross References - Protein

canSAR P56199
Human Protein Atlas ENSG00000213949
IntAct P56199
Guide to Pharmacology 2437
Open Targets ENSG00000213949
PharmGKB PA29935
Reactome R-HSA-216083 (Integrin cell surface interactions.)
R-HSA-3000157 (Laminin interactions.)
R-HSA-416700 (Other semaphorin interactions.)
R-HSA-445355 (Smooth Muscle Contraction.)
R-HSA-447041 (CHL1 interactions.)
R-HSA-75892 (Platelet Adhesion to exposed collagen.)
TIMBAL Integrins
UniProt B2RNU0 P56199

Target Cross References - Domain

InterPro IPR000413 (Integrin_alpha.)
IPR002035 (VWF_A.)
IPR013517 (FG-GAP.)
IPR013519 (Int_alpha_beta-p.)
IPR013649 (Integrin_alpha-2.)
IPR018184 (Integrin_alpha_C_CS.)
IPR028994 (Integrin_alpha_N.)
IPR032695 (Integrin_dom_sf.)
IPR036465 (vWFA_dom_sf.)
Pfam PF00092 (VWA)
PF01839 (FG-GAP)
PF08441 (Integrin_alpha2)

Target Cross References - Structure

PDBe 1PT6 1QC5 1QCY 4A0Q 5HGJ
CREDO 1PT6 1QC5 1QCY 4A0Q 5HGJ
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