ChEMBL logo

ChEMBL

spacer
ChEMBL Statistics
  Loading Statistics...
spacer

Target Report Card

Target Name and Classification

Target ID CHEMBL3663
Target Type SINGLE PROTEIN
Preferred Name Growth factor receptor-bound protein 2
Synonyms ASH | Adapter protein GRB2 | GRB2 | Growth factor receptor-bound protein 2 | Protein Ash | SH2/SH3 adapter GRB2
Organism Homo sapiens
Species Group No
Protein Target Classification
  • other cytosolic protein

Target Components

Component Description Relationship Accession
Growth factor receptor-bound protein 2 SINGLE PROTEIN P62993

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000177885
Ensembl ENSG00000177885
GO Cellular Component GO:0005634 (nucleus)
GO:0005654 (nucleoplasm)
GO:0005730 (nucleolus)
GO:0005737 (cytoplasm)
GO:0005768 (endosome)
GO:0005794 (Golgi apparatus)
GO:0005829 (cytosol)
GO:0005886 (plasma membrane)
GO:0005911 (cell-cell junction)
GO:0008180 (COP9 signalosome)
GO:0012506 (vesicle membrane)
GO:0016020 (membrane)
GO:0070062 (extracellular exosome)
GO:0070436 (Grb2-EGFR complex)
GO Molecular Function GO:0005070 (SH3/SH2 adaptor activity)
GO:0005088 (Ras guanyl-nucleotide exchange factor activity)
GO:0005154 (epidermal growth factor receptor binding)
GO:0005168 (neurotrophin TRKA receptor binding)
GO:0005515 (protein binding)
GO:0016303 (1-phosphatidylinositol-3-kinase activity)
GO:0017124 (SH3 domain binding)
GO:0019901 (protein kinase binding)
GO:0019903 (protein phosphatase binding)
GO:0019904 (protein domain specific binding)
GO:0042802 (identical protein binding)
GO:0043560 (insulin receptor substrate binding)
GO:0044822 (poly(A) RNA binding)
GO:0046875 (ephrin receptor binding)
GO:0046934 (phosphatidylinositol-4,5-bisphosphate 3-kinase activity)
GO Biological Process GO:0000165 (MAPK cascade)
GO:0007173 (epidermal growth factor receptor signaling pathway)
GO:0007265 (Ras protein signal transduction)
GO:0007267 (cell-cell signaling)
GO:0007411 (axon guidance)
GO:0008286 (insulin receptor signaling pathway)
GO:0008543 (fibroblast growth factor receptor signaling pathway)
GO:0009967 (positive regulation of signal transduction)
GO:0014066 (regulation of phosphatidylinositol 3-kinase signaling)
GO:0016032 (viral process)
GO:0030154 (cell differentiation)
GO:0030838 (positive regulation of actin filament polymerization)
GO:0031295 (T cell costimulation)
GO:0031623 (receptor internalization)
GO:0036092 (phosphatidylinositol-3-phosphate biosynthetic process)
GO:0038095 (Fc-epsilon receptor signaling pathway)
GO:0038096 (Fc-gamma receptor signaling pathway involved in phagocytosis)
GO:0038128 (ERBB2 signaling pathway)
GO:0042059 (negative regulation of epidermal growth factor receptor signaling pathway)
GO:0042770 (signal transduction in response to DNA damage)
GO:0043408 (regulation of MAPK cascade)
GO:0043547 (positive regulation of GTPase activity)
GO:0046854 (phosphatidylinositol phosphorylation)
GO:0048015 (phosphatidylinositol-mediated signaling)
GO:0048646 (anatomical structure formation involved in morphogenesis)
GO:0050900 (leukocyte migration)
GO:0060670 (branching involved in labyrinthine layer morphogenesis)
GO:0071479 (cellular response to ionizing radiation)
GO:2000379 (positive regulation of reactive oxygen species metabolic process)
Wikipedia GRB2

Target Cross References - Protein

canSAR P62993
Human Protein Atlas ENSG00000177885
IntAct P62993
Open Targets ENSG00000177885
PharmGKB PA28962
Reactome R-HSA-109704 (PI3K Cascade.)
R-HSA-112412 (SOS-mediated signalling.)
R-HSA-114604 (GPVI-mediated activation cascade.)
R-HSA-1236382 (Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants.)
R-HSA-1250196 (SHC1 events in ERBB2 signaling.)
R-HSA-1250347 (SHC1 events in ERBB4 signaling.)
R-HSA-1257604 (PIP3 activates AKT signaling.)
R-HSA-1295596 (Spry regulation of FGF signaling.)
R-HSA-1433557 (Signaling by SCF-KIT.)
R-HSA-1433559 (Regulation of KIT signaling.)
R-HSA-167044 (Signalling to RAS.)
R-HSA-179812 (GRB2 events in EGFR signaling.)
R-HSA-180292 (GAB1 signalosome.)
R-HSA-180336 (SHC1 events in EGFR signaling.)
R-HSA-182971 (EGFR downregulation.)
R-HSA-1839117 (Signaling by cytosolic FGFR1 fusion mutants.)
R-HSA-186763 (Downstream signal transduction.)
R-HSA-1963640 (GRB2 events in ERBB2 signaling.)
R-HSA-1963642 (PI3K events in ERBB2 signaling.)
R-HSA-2029482 (Regulation of actin dynamics for phagocytic cup formation.)
R-HSA-210993 (Tie2 Signaling.)
R-HSA-2179392 (EGFR Transactivation by Gastrin.)
R-HSA-2219530 (Constitutive Signaling by Aberrant PI3K in Cancer.)
R-HSA-2424491 (DAP12 signaling.)
R-HSA-2428933 (SHC-related events triggered by IGF1R.)
R-HSA-2730905 (Role of LAT2/NTAL/LAB on calcium mobilization.)
R-HSA-2871796 (FCERI mediated MAPK activation.)
R-HSA-2871809 (FCERI mediated Ca+2 mobilization.)
R-HSA-354194 (GRB2:SOS provides linkage to MAPK signaling for Integrins.)
R-HSA-375165 (NCAM signaling for neurite out-growth.)
R-HSA-388841 (Costimulation by the CD28 family.)
R-HSA-389359 (CD28 dependent Vav1 pathway.)
R-HSA-391160 (Signal regulatory protein (SIRP) family interactions.)
R-HSA-392451 (G beta:gamma signalling through PI3Kgamma.)
R-HSA-512988 (Interleukin-3, 5 and GM-CSF signaling.)
R-HSA-5637810 (Constitutive Signaling by EGFRvIII.)
R-HSA-5654688 (SHC-mediated cascade:FGFR1.)
R-HSA-5654689 (PI-3K cascade:FGFR1.)
R-HSA-5654693 (FRS-mediated FGFR1 signaling.)
R-HSA-5654695 (PI-3K cascade:FGFR2.)
R-HSA-5654699 (SHC-mediated cascade:FGFR2.)
R-HSA-5654700 (FRS-mediated FGFR2 signaling.)
R-HSA-5654704 (SHC-mediated cascade:FGFR3.)
R-HSA-5654706 (FRS-mediated FGFR3 signaling.)
R-HSA-5654710 (PI-3K cascade:FGFR3.)
R-HSA-5654712 (FRS-mediated FGFR4 signaling.)
R-HSA-5654719 (SHC-mediated cascade:FGFR4.)
R-HSA-5654720 (PI-3K cascade:FGFR4.)
R-HSA-5654726 (Negative regulation of FGFR1 signaling.)
R-HSA-5654727 (Negative regulation of FGFR2 signaling.)
R-HSA-5654732 (Negative regulation of FGFR3 signaling.)
R-HSA-5654733 (Negative regulation of FGFR4 signaling.)
R-HSA-5655253 (Signaling by FGFR2 in disease.)
R-HSA-5655291 (Signaling by FGFR4 in disease.)
R-HSA-5655302 (Signaling by FGFR1 in disease.)
R-HSA-5663213 (RHO GTPases Activate WASPs and WAVEs.)
R-HSA-5673001 (RAF/MAP kinase cascade.)
R-HSA-6811558 (PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling.)
R-HSA-74749 (Signal attenuation.)
R-HSA-74751 (Insulin receptor signalling cascade.)
R-HSA-8853334 (Signaling by FGFR3 fusions in cancer.)
R-HSA-8853338 (Signaling by FGFR3 point mutants in cancer.)
R-HSA-912526 (Interleukin receptor SHC signaling.)
R-HSA-912631 (Regulation of signaling by CBL.)
R-HSA-983695 (Antigen activates B Cell Receptor (BCR) leading to generation of second messengers.)
UniProt P29354 P62993 Q14450 Q63057 Q63059

Target Cross References - Domain

InterPro IPR000980 (SH2.)
IPR001452 (SH3_domain.)
Pfam PF00017 (SH2)
PF00018 (SH3_1)

Target Cross References - Structure

PDBe 1BM2 1BMB 1CJ1 1FYR 1GCQ 1GRI 1JYQ 1JYR 1JYU 1TZE 1ZFP 2AOA 2AOB 2H46 2H5K 2HUW 2VVK 2VWF 2W0Z 3C7I 3IMD 3IMJ 3IN7 3IN8 More...
CREDO 1BM2 1BMB 1CJ1 1FYR 1GCQ 1GRI 1JYQ 1JYR 1JYU 1TZE 1ZFP 2AOA 2AOB 2H46 2H5K 2HUW 2VVK 2VWF 2W0Z 3C7I 3IMD 3IMJ 3IN7 3IN8 More...
spacer
spacer