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Target Report Card

Target Name and Classification

Target ID CHEMBL3660
Preferred Name Vitronectin receptor alpha
Synonyms CD_antigen=CD51 | ITGAV | Integrin alpha-V heavy chain | Integrin alpha-V light chain | Integrin alpha-V | Synonyms=MSK8 | VNRA | Vitronectin receptor subunit alpha | Vitronectin receptor
Organism Homo sapiens
Species Group No
Protein Target Classification
  • membrane receptor

Target Components

Component Description Relationship Accession
Integrin alpha-V SINGLE PROTEIN P06756

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL3430892 Integrin alpha-V/beta PROTEIN COMPLEX
CHEMBL2111443 Integrin alpha-V/beta-3 and alpha-IIb/beta 3 SELECTIVITY GROUP
CHEMBL3430893 Integrin alpha-V/alpha-5 PROTEIN COMPLEX
CHEMBL1907598 Integrin alpha-V/beta-3 PROTEIN COMPLEX
CHEMBL2111425 Fibronectin receptor (Integrin alpha-5/beta-1 and alpha-V/beta-3) PROTEIN COMPLEX GROUP
CHEMBL2111416 Integrin alpha-V/beta-6 PROTEIN COMPLEX
CHEMBL2111407 Integrin alpha-V/beta-1 PROTEIN COMPLEX
CHEMBL2096675 Integrin alpha-V/beta-5 PROTEIN COMPLEX

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL2109621 ABITUZUMAB Vitronectin receptor alpha inhibitor 2 PubMed
CHEMBL2109633 IMGN-388 Vitronectin receptor alpha binding agent 1 PubMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000138448
Ensembl ENSG00000138448
GO Cellular Component GO:0005829 (cytosol)
GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0005925 (focal adhesion)
GO:0008305 (integrin complex)
GO:0009897 (external side of plasma membrane)
GO:0009986 (cell surface)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0030054 (cell junction)
GO:0031258 (lamellipodium membrane)
GO:0031527 (filopodium membrane)
GO:0031528 (microvillus membrane)
GO:0032587 (ruffle membrane)
GO:0034683 (integrin alphav-beta3 complex)
GO:0034684 (integrin alphav-beta5 complex)
GO:0034685 (integrin alphav-beta6 complex)
GO:0034686 (integrin alphav-beta8 complex)
GO:0035579 (specific granule membrane)
GO:0035866 (alphav-beta3 integrin-PKCalpha complex)
GO:0035867 (alphav-beta3 integrin-IGF-1-IGF1R complex)
GO:0035868 (alphav-beta3 integrin-HMGB1 complex)
GO:0045335 (phagocytic vesicle)
GO:0070062 (extracellular exosome)
GO Molecular Function GO:0001618 (virus receptor activity)
GO:0001846 (opsonin binding)
GO:0001968 (fibronectin binding)
GO:0002020 (protease binding)
GO:0005080 (protein kinase C binding)
GO:0005102 (receptor binding)
GO:0005178 (integrin binding)
GO:0005245 (voltage-gated calcium channel activity)
GO:0005515 (protein binding)
GO:0015026 (coreceptor activity)
GO:0017134 (fibroblast growth factor binding)
GO:0019960 (C-X3-C chemokine binding)
GO:0031994 (insulin-like growth factor I binding)
GO:0038132 (neuregulin binding)
GO:0042277 (peptide binding)
GO:0046872 (metal ion binding)
GO:0050431 (transforming growth factor beta binding)
GO:0050840 (extracellular matrix binding)
GO:1990430 (extracellular matrix protein binding)
GO Biological Process GO:0001525 (angiogenesis)
GO:0001568 (blood vessel development)
GO:0001570 (vasculogenesis)
GO:0002479 (antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent)
GO:0006874 (cellular calcium ion homeostasis)
GO:0007155 (cell adhesion)
GO:0007160 (cell-matrix adhesion)
GO:0007204 (positive regulation of cytosolic calcium ion concentration)
GO:0007229 (integrin-mediated signaling pathway)
GO:0008284 (positive regulation of cell proliferation)
GO:0010745 (negative regulation of macrophage derived foam cell differentiation)
GO:0010888 (negative regulation of lipid storage)
GO:0016032 (viral process)
GO:0016477 (cell migration)
GO:0030198 (extracellular matrix organization)
GO:0030335 (positive regulation of cell migration)
GO:0031589 (cell-substrate adhesion)
GO:0032369 (negative regulation of lipid transport)
GO:0033627 (cell adhesion mediated by integrin)
GO:0033690 (positive regulation of osteoblast proliferation)
GO:0034113 (heterotypic cell-cell adhesion)
GO:0034446 (substrate adhesion-dependent cell spreading)
GO:0035987 (endodermal cell differentiation)
GO:0038027 (apolipoprotein A-I-mediated signaling pathway)
GO:0038044 (transforming growth factor-beta secretion)
GO:0043277 (apoptotic cell clearance)
GO:0043312 (neutrophil degranulation)
GO:0043410 (positive regulation of MAPK cascade)
GO:0045715 (negative regulation of low-density lipoprotein particle receptor biosynthetic process)
GO:0045785 (positive regulation of cell adhesion)
GO:0046718 (viral entry into host cell)
GO:0048010 (vascular endothelial growth factor receptor signaling pathway)
GO:0050748 (negative regulation of lipoprotein metabolic process)
GO:0050764 (regulation of phagocytosis)
GO:0050900 (leukocyte migration)
GO:0050919 (negative chemotaxis)
GO:0052066 (entry of symbiont into host cell by promotion of host phagocytosis)
GO:0070371 (ERK1 and ERK2 cascade)
GO:0070588 (calcium ion transmembrane transport)
GO:0097192 (extrinsic apoptotic signaling pathway in absence of ligand)
GO:2000536 (negative regulation of entry of bacterium into host cell)
GO:2001237 (negative regulation of extrinsic apoptotic signaling pathway)
Wikipedia ITGAV

Target Cross References - Protein

canSAR P06756
Human Protein Atlas ENSG00000138448
IntAct P06756
Guide to Pharmacology 2453
Open Targets ENSG00000138448
PharmGKB PA37336
Reactome R-HSA-1236973 (Cross-presentation of particulate exogenous antigens (phagosomes).)
R-HSA-1566948 (Elastic fibre formation.)
R-HSA-210990 (PECAM1 interactions.)
R-HSA-2129379 (Molecules associated with elastic fibres.)
R-HSA-216083 (Integrin cell surface interactions.)
R-HSA-3000157 (Laminin interactions.)
R-HSA-3000170 (Syndecan interactions.)
R-HSA-3000178 (ECM proteoglycans.)
R-HSA-4420097 (VEGFA-VEGFR2 Pathway.)
R-HSA-445144 (Signal transduction by L1.)
R-HSA-6798695 (Neutrophil degranulation.)
UniProt A0AV67 B0LPF4 B7Z883 B7ZLX0 D3DPG8 E7EWZ6 P06756 Q53SK4 Q59EB7 Q6LD15

Target Cross References - Domain

InterPro IPR000413 (Integrin_alpha.)
IPR013517 (FG-GAP.)
IPR013519 (Int_alpha_beta-p.)
IPR013649 (Integrin_alpha-2.)
IPR018184 (Integrin_alpha_C_CS.)
IPR028994 (Integrin_alpha_N.)
IPR032695 (Integrin_dom_sf.)
Pfam PF00357 (Integrin_alpha)
PF01839 (FG-GAP)
PF08441 (Integrin_alpha2)

Target Cross References - Structure

PDBe 1JV2 1L5G 1M1X 1U8C 3IJE 4G1E 4G1M 4MMX 4MMY 4MMZ 4O02 4UM8 4UM9 5FFG 5FFO
CREDO 1JV2 1L5G 1M1X 1U8C 3IJE 4G1E 4G1M 4MMX 4MMY 4MMZ 4O02 4UM8 4UM9 5FFG 5FFO