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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL3660
Preferred Name Vitronectin receptor alpha
Synonyms CD_antigen=CD51 | ITGAV | Integrin alpha-V heavy chain | Integrin alpha-V light chain | Integrin alpha-V | MSK8 | VNRA | Vitronectin receptor subunit alpha
Organism Homo sapiens
Species Group No
Protein Target Classification
  • membrane receptor

Target Components

Component Description Relationship Accession
Integrin alpha-V SINGLE PROTEIN P06756

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2096675 Integrin alpha-V/beta-5 PROTEIN COMPLEX
CHEMBL1907598 Integrin alpha-V/beta-3 PROTEIN COMPLEX
CHEMBL2111407 Integrin alpha-V/beta-1 PROTEIN COMPLEX
CHEMBL2111416 Integrin alpha-V/beta-6 PROTEIN COMPLEX
CHEMBL2111443 Integrin alpha-V/beta-3 and alpha-IIb/beta 3 SELECTIVITY GROUP
CHEMBL2111425 Fibronectin receptor (Integrin alpha-5/beta-1 and alpha-V/beta-3) PROTEIN COMPLEX GROUP

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000138448
Ensembl ENSG00000138448
GO Cellular Component GO:0005622 (intracellular)
GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0005925 (focal adhesion)
GO:0008305 (integrin complex)
GO:0009897 (external side of plasma membrane)
GO:0009986 (cell surface)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0031258 (lamellipodium membrane)
GO:0031527 (filopodium membrane)
GO:0031528 (microvillus membrane)
GO:0032587 (ruffle membrane)
GO:0034683 (integrin alphav-beta3 complex)
GO:0034684 (integrin alphav-beta5 complex)
GO:0034686 (integrin alphav-beta8 complex)
GO:0035867 (alphav-beta3 integrin-IGF-1-IGF1R complex)
GO:0045335 (phagocytic vesicle)
GO:0070062 (extracellular exosome)
GO Molecular Function GO:0001618 (virus receptor activity)
GO:0001846 (opsonin binding)
GO:0001968 (fibronectin binding)
GO:0002020 (protease binding)
GO:0005080 (protein kinase C binding)
GO:0005245 (voltage-gated calcium channel activity)
GO:0005515 (protein binding)
GO:0015026 (coreceptor activity)
GO:0017134 (fibroblast growth factor binding)
GO:0019960 (C-X3-C chemokine binding)
GO:0031994 (insulin-like growth factor I binding)
GO:0038132 (neuregulin binding)
GO:0046872 (metal ion binding)
GO:0050431 (transforming growth factor beta binding)
GO:0050840 (extracellular matrix binding)
GO:1990430 (extracellular matrix protein binding)
GO Biological Process GO:0001525 (angiogenesis)
GO:0001568 (blood vessel development)
GO:0002479 (antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent)
GO:0007155 (cell adhesion)
GO:0007160 (cell-matrix adhesion)
GO:0007229 (integrin-mediated signaling pathway)
GO:0008284 (positive regulation of cell proliferation)
GO:0010745 (negative regulation of macrophage derived foam cell differentiation)
GO:0010888 (negative regulation of lipid storage)
GO:0016032 (viral process)
GO:0016049 (cell growth)
GO:0016477 (cell migration)
GO:0030198 (extracellular matrix organization)
GO:0030335 (positive regulation of cell migration)
GO:0031589 (cell-substrate adhesion)
GO:0032369 (negative regulation of lipid transport)
GO:0033690 (positive regulation of osteoblast proliferation)
GO:0034113 (heterotypic cell-cell adhesion)
GO:0034446 (substrate adhesion-dependent cell spreading)
GO:0035987 (endodermal cell differentiation)
GO:0038027 (apolipoprotein A-I-mediated signaling pathway)
GO:0043277 (apoptotic cell clearance)
GO:0045715 (negative regulation of low-density lipoprotein particle receptor biosynthetic process)
GO:0045785 (positive regulation of cell adhesion)
GO:0046718 (viral entry into host cell)
GO:0048010 (vascular endothelial growth factor receptor signaling pathway)
GO:0050748 (negative regulation of lipoprotein metabolic process)
GO:0050764 (regulation of phagocytosis)
GO:0050900 (leukocyte migration)
GO:0050919 (negative chemotaxis)
GO:0052066 (entry of symbiont into host cell by promotion of host phagocytosis)
GO:0070371 (ERK1 and ERK2 cascade)
GO:0070588 (calcium ion transmembrane transport)
GO:0097192 (extrinsic apoptotic signaling pathway in absence of ligand)
GO:2000425 (regulation of apoptotic cell clearance)
GO:2000536 (negative regulation of entry of bacterium into host cell)
GO:2001237 (negative regulation of extrinsic apoptotic signaling pathway)
Wikipedia ITGAV

Target Cross References - Protein

canSAR P06756
Human Protein Atlas ENSG00000138448
IntAct P06756
Open Targets ENSG00000138448
PharmGKB PA37336
Reactome R-HSA-1236973 (Cross-presentation of particulate exogenous antigens (phagosomes).)
R-HSA-1566948 (Elastic fibre formation.)
R-HSA-210990 (PECAM1 interactions.)
R-HSA-2129379 (Molecules associated with elastic fibres.)
R-HSA-216083 (Integrin cell surface interactions.)
R-HSA-3000157 (Laminin interactions.)
R-HSA-3000170 (Syndecan interactions.)
R-HSA-3000178 (ECM proteoglycans.)
R-HSA-4420097 (VEGFA-VEGFR2 Pathway.)
R-HSA-445144 (Signal transduction by L1.)
UniProt A0AV67 B0LPF4 B7Z883 B7ZLX0 D3DPG8 E7EWZ6 P06756 Q53SK4 Q59EB7 Q6LD15

Target Cross References - Domain

InterPro IPR000413 (Integrin_alpha.)
IPR013517 (FG-GAP.)
IPR013519 (Int_alpha_beta-p.)
IPR013649 (Integrin_alpha-2.)
IPR018184 (Integrin_alpha_C_CS.)
IPR032695 (Integrin_dom.)
Pfam PF00357 (Integrin_alpha)
PF01839 (FG-GAP)
PF08441 (Integrin_alpha2)

Target Cross References - Structure

PDBe 1JV2 1L5G 1M1X 1U8C 3IJE 4G1E 4G1M 4MMX 4MMY 4MMZ 4O02 4UM8 4UM9
CREDO 1JV2 1L5G 1M1X 1U8C 3IJE 4G1E 4G1M 4MMX 4MMY 4MMZ 4O02 4UM8 4UM9