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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL3650
Target Type SINGLE PROTEIN
Preferred Name Fibroblast growth factor receptor 1
Synonyms BFGFR | BFGFR | Basic fibroblast growth factor receptor 1 | CD_antigen=CD331 | CEK | FGFBR | FGFR-1 | FGFR1 | FLG | FLT-2 | FLT2 | Fibroblast growth factor receptor 1 | Fms-like tyrosine kinase 2 | HBGFR | N-sam | Proto-oncogene c-Fgr | bFGF-R-1
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > tk protein kinase group > tyrosine protein kinase fgfr family

Target Components

Component Description Relationship Accession
Fibroblast growth factor receptor 1 SINGLE PROTEIN P11362

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2095217 Fibroblast growth factor receptor PROTEIN FAMILY
CHEMBL2111439 VEGF-receptor 2 and Fibroblast growth factor receptor 1 PROTEIN FAMILY

Approved Drugs

ChEMBL ID Name Mechanism of Action References
CHEMBL1201733 PAZOPANIB HYDROCHLORIDE Fibroblast growth factor receptor 1 inhibitor DailyMed
CHEMBL1946170 REGORAFENIB Fibroblast growth factor receptor 1 inhibitor Expert

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000077782
Ensembl ENSG00000077782
GO Cellular Component GO:0005576 (extracellular region)
GO:0005624 (membrane fraction)
GO:0005887 (integral to plasma membrane)
GO Molecular Function GO:0005007 (fibroblast growth factor receptor activity)
GO:0005524 (ATP binding)
GO:0008201 (heparin binding)
GO:0042803 (protein homodimerization activity)
GO Biological Process GO:0000165 (MAPKKK cascade)
GO:0001501 (skeletal system development)
GO:0006468 (protein phosphorylation)
GO:0007411 (axon guidance)
GO:0008284 (positive regulation of cell proliferation)
GO:0008286 (insulin receptor signaling pathway)
GO:0016049 (cell growth)
Wikipedia Fibroblast_growth_factor_receptor_1

Target Cross References - Protein

canSAR P11362
CGD Hypogonadotropic hypogonadism; Kallmann syndrome; Trigonocephaly 1; Jackson-Weiss syndrome; Pfeiffer syndrome
Human Protein Atlas ENSG00000077782
IntAct P11362
Guide to Pharmacology 1808 (fibroblast growth factor receptor 1)
PharmGKB PA28127
Reactome REACT_18266 (Axon guidance.)
REACT_498 (Signaling by Insulin receptor.)
REACT_9470 (Signaling by FGFR.)
UniProt A8K6T9 A8K8V5 C1KBH8 P11362 P17049 Q02063 Q02065 Q14306 Q14307 Q53H63 Q59H40 Q5BJG2 Q8N685 Q9UD50 Q9UDF0 Q9UDF1 Q9UDF2

Target Cross References - Domain

InterPro IPR000719 (Prot_kinase_cat_dom.)
IPR001245 (Ser-Thr/Tyr-Pkinase.)
IPR003598 (Ig_sub2.)
IPR007110 (Ig-like.)
IPR008266 (Tyr_prot_kinase_AS.)
IPR011009 (Kinase-like_dom.)
IPR013098 (Ig_I-set.)
IPR013783 (Ig-like_fold.)
IPR016248 (Tyr_kinase_fibroblast_GF_rcpt.)
IPR017441 (Protein_kinase_ATP_BS.)
IPR020635 (Tyr_Pkinase_cat_dom.)
Pfam PF07679 (I-set)
PF07714 (Pkinase_Tyr)

Target Cross References - Structure

PDBe 1AGW 1CVS 1EVT 1FGI 1FGK 1FQ9 2FGI 3C4F 3GQI 3GQL 3JS2 3KRJ 3KRL 3KXX 3KY2 3RHX
CREDO 1AGW 1CVS 1EVT 1FGI 1FGK 1FQ9 2FGI 3C4F 3GQI 3GQL 3JS2 3KRJ 3KRL 3KXX 3KY2 3RHX
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