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Target Report Card

Target Name and Classification

Target ID CHEMBL3638
Preferred Name RAS guanyl releasing protein 3
Synonyms Calcium and DAG-regulated guanine nucleotide exchange factor III | GRP3 | Guanine nucleotide exchange factor for Rap1 | KIAA0846 | RASGRP3 | Ras guanyl-releasing protein 3
Organism Homo sapiens
Species Group No
Protein Target Classification
  • other cytosolic protein

Target Components

Component Description Relationship Accession
Ras guanyl-releasing protein 3 SINGLE PROTEIN Q8IV61

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000152689
Ensembl ENSG00000152689
GO Cellular Component GO:0005737 (cytoplasm)
GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0032045 (guanyl-nucleotide exchange factor complex)
GO:0048471 (perinuclear region of cytoplasm)
GO Molecular Function GO:0004871 (signal transducer activity)
GO:0005085 (guanyl-nucleotide exchange factor activity)
GO:0005088 (Ras guanyl-nucleotide exchange factor activity)
GO:0005096 (GTPase activator activity)
GO:0005509 (calcium ion binding)
GO:0005515 (protein binding)
GO:0017016 (Ras GTPase binding)
GO:0019900 (kinase binding)
GO:0019992 (diacylglycerol binding)
GO:0046872 (metal ion binding)
GO Biological Process GO:0000165 (MAPK cascade)
GO:0007264 (small GTPase mediated signal transduction)
GO:0007265 (Ras protein signal transduction)
GO:0035556 (intracellular signal transduction)
GO:0043087 (regulation of GTPase activity)
GO:0043547 (positive regulation of GTPase activity)
Wikipedia RASGRP3

Target Cross References - Protein

canSAR Q8IV61
Human Protein Atlas ENSG00000152689
IntAct Q8IV61
Open Targets ENSG00000152689
PharmGKB PA134937092
Reactome R-HSA-1169092 (Activation of RAS in B cells.)
R-HSA-5673001 (RAF/MAP kinase cascade.)
UniProt D6W583 O94931 Q53SD7 Q8IV61

Target Cross References - Domain

InterPro IPR000651 (Ras-like_Gua-exchang_fac_N.)
IPR001895 (RASGEF_cat_dom.)
IPR002048 (EF_hand_dom.)
IPR002219 (PE/DAG-bd.)
IPR011992 (EF-hand-dom_pair.)
IPR018247 (EF_Hand_1_Ca_BS.)
IPR020454 (DAG/PE-bd.)
IPR023578 (Ras_GEF_dom.)
IPR029645 (RASGRP3.)
Pfam PF00130 (C1_1)
PF00617 (RasGEF)
PF13202 (EF-hand_5)