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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL3631
Preferred Name Integrin beta-2
Synonyms CD18 | CD_antigen=CD18 | Cell surface adhesion glycoproteins LFA-1/CR3/p150,95 subunit beta | Complement receptor C3 subunit beta | ITGB2 | Integrin beta-2 | MFI7
Organism Homo sapiens
Species Group No
Protein Target Classification
  • membrane receptor

Target Components

Component Description Relationship Accession
Integrin beta-2 SINGLE PROTEIN P05107

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2096661 Intercellular adhesion molecule (ICAM-1), Integrin alpha-L/beta-2 PROTEIN COMPLEX
CHEMBL2364172 Integrin alpha-L/beta-2 (LFA-1) PROTEIN COMPLEX
CHEMBL2111362 Integrin alpha-M/beta-2 PROTEIN COMPLEX

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL2109095 ERLIZUMAB Integrin beta-2 negative modulator 2 PubMed
CHEMBL2109332 MLNM-2201 Integrin beta-2 inhibitor 2 Other
CHEMBL2109346 AME-133V Integrin beta-2 inhibitor 2 PubMed PubMed
CHEMBL2109496 MLN-01 Integrin beta-2 inhibitor 1 ISBN Other

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000160255
Ensembl ENSG00000160255
GO Cellular Component GO:0005886 (plasma membrane)
GO:0008305 (integrin complex)
GO:0009897 (external side of plasma membrane)
GO:0009986 (cell surface)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0034687 (integrin alphaL-beta2 complex)
GO:0034688 (integrin alphaM-beta2 complex)
GO:0035579 (specific granule membrane)
GO:0043235 (receptor complex)
GO:0044853 (plasma membrane raft)
GO:0045121 (membrane raft)
GO:0070062 (extracellular exosome)
GO:0070821 (tertiary granule membrane)
GO:0099568 (cytoplasmic region)
GO:0101003 (ficolin-1-rich granule membrane)
GO:1903561 (extracellular vesicle)
GO Molecular Function GO:0001540 (beta-amyloid binding)
GO:0001851 (complement component C3b binding)
GO:0005515 (protein binding)
GO:0019901 (protein kinase binding)
GO:0030369 (ICAM-3 receptor activity)
GO:0031072 (heat shock protein binding)
GO:0038023 (signaling receptor activity)
GO:0044877 (macromolecular complex binding)
GO:0046872 (metal ion binding)
GO:0046982 (protein heterodimerization activity)
GO:0050839 (cell adhesion molecule binding)
GO Biological Process GO:0002523 (leukocyte migration involved in inflammatory response)
GO:0006909 (phagocytosis)
GO:0006911 (phagocytosis, engulfment)
GO:0006915 (apoptotic process)
GO:0006954 (inflammatory response)
GO:0007155 (cell adhesion)
GO:0007159 (leukocyte cell-cell adhesion)
GO:0007160 (cell-matrix adhesion)
GO:0007229 (integrin-mediated signaling pathway)
GO:0007267 (cell-cell signaling)
GO:0007568 (aging)
GO:0008360 (regulation of cell shape)
GO:0019221 (cytokine-mediated signaling pathway)
GO:0030101 (natural killer cell activation)
GO:0030198 (extracellular matrix organization)
GO:0030593 (neutrophil chemotaxis)
GO:0031623 (receptor internalization)
GO:0032930 (positive regulation of superoxide anion generation)
GO:0034113 (heterotypic cell-cell adhesion)
GO:0034142 (toll-like receptor 4 signaling pathway)
GO:0035987 (endodermal cell differentiation)
GO:0043113 (receptor clustering)
GO:0043312 (neutrophil degranulation)
GO:0043315 (positive regulation of neutrophil degranulation)
GO:0043542 (endothelial cell migration)
GO:0045123 (cellular extravasation)
GO:0045429 (positive regulation of nitric oxide biosynthetic process)
GO:0045766 (positive regulation of angiogenesis)
GO:0050730 (regulation of peptidyl-tyrosine phosphorylation)
GO:0050776 (regulation of immune response)
GO:0050900 (leukocyte migration)
GO:0051092 (positive regulation of NF-kappaB transcription factor activity)
GO:0071404 (cellular response to low-density lipoprotein particle stimulus)
GO:0097242 (amyloid-beta clearance)
GO:0098609 (cell-cell adhesion)
GO:0098742 (cell-cell adhesion via plasma-membrane adhesion molecules)
GO:1990266 (neutrophil migration)
Wikipedia CD18

Target Cross References - Protein

canSAR P05107
CGD Leukocyte adhesion deficiency, type I
Human Protein Atlas ENSG00000160255
IntAct P05107
Guide to Pharmacology 2456
Open Targets ENSG00000160255
PharmGKB PA29955
Reactome R-HSA-166016 (Toll Like Receptor 4 (TLR4) Cascade.)
R-HSA-198933 (Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.)
R-HSA-202733 (Cell surface interactions at the vascular wall.)
R-HSA-216083 (Integrin cell surface interactions.)
R-HSA-6785807 (Interleukin-4 and 13 signaling.)
R-HSA-6798695 (Neutrophil degranulation.)
TIMBAL Integrins
UniProt B3KTS8 D3DSM1 P05107 Q16418 Q53HS5 Q9UD72

Target Cross References - Domain

InterPro IPR002369 (Integrin_bsu_VWA.)
IPR012896 (Integrin_bsu_tail.)
IPR014836 (Integrin_bsu_cyt_dom.)
IPR015439 (Integrin_bsu-2.)
IPR015812 (Integrin_bsu.)
IPR016201 (PSI.)
IPR032695 (Integrin_dom_sf.)
IPR033760 (Integrin_beta_N.)
IPR036349 (Integrin_bsu_tail_dom_sf.)
IPR036465 (vWFA_dom_sf.)
IPR037076 (Integrin_bsu_cyt_dom_sf.)
Pfam PF00362 (Integrin_beta)
PF07965 (Integrin_B_tail)
PF08725 (Integrin_b_cyt)
PF17205 (PSI_integrin)

Target Cross References - Structure

PDBe 1YUK 2JF1 2P26 2P28 2V7D 3K6S 3K71 3K72 4NEH 4NEN 5E6R 5E6S 5E6U 5E6V 5E6W 5E6X 5ES4
CREDO 1YUK 2JF1 2P26 2P28 2V7D 3K6S 3K71 3K72 4NEH 4NEN 5E6R 5E6S 5E6U 5E6V 5E6W 5E6X 5ES4