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Target Report Card

Target Name and Classification

Target ID CHEMBL3622
Target Type SINGLE PROTEIN
Preferred Name Cytochrome P450 2C19
Synonyms (R)-limonene 6-monooxygenase | (S)-limonene 6-monooxygenase | (S)-limonene 7-monooxygenase | CYP2C19 | CYPIIC17 | CYPIIC19 | Cytochrome P450 2C19 | Cytochrome P450-11A | Cytochrome P450-254C | Mephenytoin 4-hydroxylase
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > cytochrome p450 > cytochrome p450 family 2 > cytochrome p450 family 2c > cytochrome p450 2c19

Target Components

Component Description Relationship Accession
Cytochrome P450 2C19 SINGLE PROTEIN P33261

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000165841
Ensembl ENSG00000165841
GO Cellular Component GO:0005783 (endoplasmic reticulum)
GO:0005789 (endoplasmic reticulum membrane)
GO:0016020 (membrane)
GO:0031090 (organelle membrane)
GO:0043231 (intracellular membrane-bounded organelle)
GO Molecular Function GO:0004497 (monooxygenase activity)
GO:0005506 (iron ion binding)
GO:0008392 (arachidonic acid epoxygenase activity)
GO:0008395 (steroid hydroxylase activity)
GO:0016491 (oxidoreductase activity)
GO:0016705 (oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen)
GO:0018675 ((S)-limonene 6-monooxygenase activity)
GO:0018676 ((S)-limonene 7-monooxygenase activity)
GO:0019825 (oxygen binding)
GO:0019899 (enzyme binding)
GO:0020037 (heme binding)
GO:0046872 (metal ion binding)
GO:0052741 ((R)-limonene 6-monooxygenase activity)
GO Biological Process GO:0006805 (xenobiotic metabolic process)
GO:0008202 (steroid metabolic process)
GO:0016098 (monoterpenoid metabolic process)
GO:0017144 (drug metabolic process)
GO:0019373 (epoxygenase P450 pathway)
GO:0042738 (exogenous drug catabolic process)
GO:0046483 (heterocycle metabolic process)
GO:0055114 (oxidation-reduction process)
GO:0097267 (omega-hydroxylase P450 pathway)
Wikipedia CYP2C19

Target Cross References - Protein

canSAR P33261
CGD Drug metabolism, CYP2C19-related
Human Protein Atlas ENSG00000165841
Guide to Pharmacology 1328
Open Targets ENSG00000165841
PharmGKB PA124
Reactome R-HSA-211981 (Xenobiotics.)
R-HSA-211999 (CYP2E1 reactions.)
R-HSA-2142670 (Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET).)
R-HSA-2142816 (Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE).)
UniProt P33259 P33261 Q8WZB1 Q8WZB2 Q9UCD4

Target Cross References - Domain

InterPro IPR001128 (Cyt_P450.)
IPR002401 (Cyt_P450_E_grp-I.)
IPR017972 (Cyt_P450_CS.)
Pfam PF00067 (p450)

Target Cross References - Structure

PDBe 4GQS
CREDO 4GQS
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