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ChEMBL

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Target Report Card

Target Name and Classification

Target ID CHEMBL3622
Target Type SINGLE PROTEIN
Preferred Name Cytochrome P450 2C19
Synonyms (R)-limonene 6-monooxygenase | (S)-limonene 6-monooxygenase | (S)-limonene 7-monooxygenase | CYP2C19 | CYPIIC17 | CYPIIC19 | Cytochrome P450 2C19 | Cytochrome P450-11A | Cytochrome P450-254C | Mephenytoin 4-hydroxylase
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > cytochrome p450 > cytochrome p450 family 2 > cytochrome p450 family 2c > cytochrome p450 2c19

Target Components

Component Description Relationship Accession
Cytochrome P450 2C19 SINGLE PROTEIN P33261

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000165841
Ensembl ENSG00000165841
GO Cellular Component GO:0043231 (intracellular membrane-bounded organelle)
GO:0005789 (endoplasmic reticulum membrane)
GO:0005737 (cytoplasm)
GO Molecular Function GO:0018676 ((S)-limonene 7-monooxygenase activity)
GO:0004497 (monooxygenase activity)
GO:0005506 (iron ion binding)
GO:0016712 (oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen)
GO:0008395 (steroid hydroxylase activity)
GO:0019899 (enzyme binding)
GO:0016491 (oxidoreductase activity)
GO:0008392 (arachidonic acid epoxygenase activity)
GO:0018675 ((S)-limonene 6-monooxygenase activity)
GO:0019825 (oxygen binding)
GO:0020037 (heme binding)
GO:0052741 ((R)-limonene 6-monooxygenase activity)
GO Biological Process GO:0008202 (steroid metabolic process)
GO:0019369 (arachidonic acid metabolic process)
GO:0044281 (small molecule metabolic process)
GO:0006805 (xenobiotic metabolic process)
GO:0017144 (drug metabolic process)
GO:0097267 (omega-hydroxylase P450 pathway)
GO:0046483 (heterocycle metabolic process)
GO:0019373 (epoxygenase P450 pathway)
GO:0016098 (monoterpenoid metabolic process)
GO:0042738 (exogenous drug catabolic process)
GO:0055114 (oxidation-reduction process)
Wikipedia CYP2C19

Target Cross References - Protein

canSAR P33261
CGD Drug metabolism, CYP2C19-related
Human Protein Atlas ENSG00000165841
Guide to Pharmacology 1328 (CYP2C19)
PharmGKB PA124
UniProt P33259 Q8WZB1 Q8WZB2 Q9UCD4 P33261

Target Cross References - Domain

InterPro IPR002401 (Cyt_P450_E_grp-I.)
IPR017972 (Cyt_P450_CS.)
IPR001128 (Cyt_P450.)
Pfam PF00067 (p450)

Target Cross References - Structure

PDBe 4GQS
CREDO 4GQS
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