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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL3618
Target Type SINGLE PROTEIN
Preferred Name Coagulation factor V
Synonyms Activated protein C cofactor | Coagulation factor V heavy chain | Coagulation factor V light chain | Coagulation factor V | F5 | Proaccelerin, labile factor
Organism Homo sapiens
Species Group No
Protein Target Classification
  • secreted protein

Target Components

Component Description Relationship Accession
Coagulation factor V SINGLE PROTEIN P12259

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL2109065 DROTRECOGIN ALFA (ACTIVATED) Coagulation factor V inhibitor 4 DailyMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000198734
Ensembl ENSG00000198734
GO Cellular Component GO:0000139 (Golgi membrane)
GO:0005576 (extracellular region)
GO:0005615 (extracellular space)
GO:0005788 (endoplasmic reticulum lumen)
GO:0005886 (plasma membrane)
GO:0016020 (membrane)
GO:0030134 (ER to Golgi transport vesicle)
GO:0031091 (platelet alpha granule)
GO:0031093 (platelet alpha granule lumen)
GO:0033116 (endoplasmic reticulum-Golgi intermediate compartment membrane)
GO:1903561 (extracellular vesicle)
GO Molecular Function GO:0005507 (copper ion binding)
GO:0005515 (protein binding)
GO:0046872 (metal ion binding)
GO Biological Process GO:0002576 (platelet degranulation)
GO:0006888 (ER to Golgi vesicle-mediated transport)
GO:0007596 (blood coagulation)
GO:0007599 (hemostasis)
GO:0008015 (blood circulation)
GO:0030168 (platelet activation)
GO:0048208 (COPII vesicle coating)
Wikipedia Factor_V

Target Cross References - Protein

CGD Factor V deficiency
Human Protein Atlas ENSG00000198734
IntAct P12259
Open Targets ENSG00000198734
PharmGKB PA159
Reactome R-HSA-114608 (Platelet degranulation.)
R-HSA-140875 (Common Pathway of Fibrin Clot Formation.)
R-HSA-204005 (COPII (Coat Protein 2) Mediated Vesicle Transport.)
R-HSA-5694530 (Cargo concentration in the ER.)
UniProt A8K6E8 P12259 Q14285 Q2EHR5 Q5R346 Q5R347 Q6UPU6 Q8WWQ6

Target Cross References - Domain

InterPro IPR000421 (FA58C.)
IPR008972 (Cupredoxin.)
IPR008979 (Galactose-bd-like.)
IPR011707 (Cu-oxidase_3.)
IPR024715 (Factor_5/8.)
IPR029821 (Factor_V.)
IPR033138 (Cu_oxidase_CS.)
Pfam PF00754 (F5_F8_type_C)
PF07732 (Cu-oxidase_3)

Target Cross References - Structure

PDBe 1CZS 1CZT 1CZV 3P6Z 3P70 3S9C
CREDO 1CZS 1CZT 1CZV 3P6Z 3P70 3S9C
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